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innate immune systemch14
innate immune systemch14

Termination of the Acute Inflammatory Response
Termination of the Acute Inflammatory Response

... Termination of the Acute Inflammatory Response To stop elimination we must stop the stimulus. The stimulus will have started a reaction in the body and our body needs to stop that reaction as well. How are these reactions stopped? The mediators produced are quickly broken down (They have a very shor ...
Mycoplasmosis
Mycoplasmosis

... “immunodeficiency”); suppression of immune response, as by drugs (known as “immunosuppression”); or cancer • Impaired resistance of the host—may allow the organism to cross the protective, mucosal barrier and spread into the body • Predisposing factors—stresses (such as reproductive problems associa ...
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Natural Defense Mechanisms

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Immune Response

... • Antigen (Ag)- is a foreign substance that can elicit specific immune response (IR) when is immunogenic • Antibody (Ab)- protein produced by the body’s immune system when it detects harmful substances called antigens • White blood cells (leukocytes)- chief function is to protect the body against mi ...
Recognition by innate immunity What is recognized by innate cells
Recognition by innate immunity What is recognized by innate cells

Immunity to infection
Immunity to infection

... reaction initiated by infection or tissue injury. The acute inflammatory response • The mediators released upregulate adhesion molecules such as P-selectin on endothelial cells. These pair with ligands on leukocytes, initially causing rolling of leukocytes along the vessel wall and then passage acro ...
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the body`s defenses

PowerPoint Presentation - Atypical Cutaneous Leishmaniasis
PowerPoint Presentation - Atypical Cutaneous Leishmaniasis

The Innate Immune Response PowerPoint
The Innate Immune Response PowerPoint

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Lecture #23 - Suraj @ LUMS

... • Some active mechanisms are triggered whenever tissue damage or disease occurs and so are called non-specific. • When they operate together in a co-ordinated way the result is called inflammation. ...
Innate immune responses to cationic antimicrobial peptides in the lung
Innate immune responses to cationic antimicrobial peptides in the lung

Acute and Chronic Inflammation - Roswell Park Cancer Institute
Acute and Chronic Inflammation - Roswell Park Cancer Institute

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Slide 1

Long noncoding RNA found to quell inflammation
Long noncoding RNA found to quell inflammation

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Pathophysiology of inflammation

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Inflammation in CNS

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Inflammatory Immune Response

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Study Guide 11 - Innate Immunity

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Modulation of inflammation by ionising radiation – impact on non

... Inflammatory reactions consistently emerge in the body. They result from temporal changes in the tissue microenvironment in response to damage. The latter can be caused by radiation of different doses, dose rates and quality. Recent work suggests that low and intermediate dose of radiation exerts an ...
Mediators of inflammation
Mediators of inflammation

... Functions of chemokinesIn acute inflammation-stimulate leukocyte attachment to endothelium by acting on leukocytes to increase the affinity of integrins, Chemotaxis Maintenance of tissue architecture homeostatic chemokines-produced constitutively in tissues ...
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12 inflammation

... 2.1 The initial steps of inflammation The inflammatory processes can be generated by pathogens or danger signals (tissue necrosis, foreign body). Pathogen patterns (PAMP) induce same processes as the danger signals (DAMP), so all the pathogen generated processes of inflammation corresponds to the me ...
11th B Hypersensitivity reactions
11th B Hypersensitivity reactions

... Hypersensitivity reactions An adaptive immune response to innocuous molecules that causes inflammation and tissue damage ...
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Inflammation



Inflammation (Latin, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants.Inflammation is a protective response that involves immune cells, blood vessels, and molecular mediators. The purpose of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and to initiate tissue repair.The classical signs of acute inflammation are pain, heat, redness, swelling, and loss of function. Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen.Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer (e.g., gallbladder carcinoma). Inflammation is therefore normally closely regulated by the body.Inflammation can be classified as either acute or chronic. Acute inflammation is the initial response of the body to harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as chronic inflammation, leads to a progressive shift in the type of cells present at the site of inflammation and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process.Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion and the reaction of the body's inflammatory defensive response — the two components are considered together when discussing an infection, and the word is used to imply a microbial invasive cause for the observed inflammatory reaction. Inflammation on the other hand describes purely the body's immunovascular response, whatever the cause may be. But because of how often the two are correlated, words ending in the suffix -itis (which refers to inflammation) are sometimes informally described as referring to infection. For example, the word urethritis strictly means only ""urethral inflammation"", but clinical health care providers usually discuss urethritis as a urethral infection because urethral microbial invasion is the most common cause of urethritis.It is useful to differentiate inflammation and infection as there are many pathological situations where inflammation is not driven by microbial invasion - for example, atherosclerosis, type III hypersensitivity, trauma, ischaemia. There are also pathological situations where microbial invasion does not result in classic inflammatory response—for example, parasitosis, eosinophilia.
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