MACROPHAGES
... 2. Perform Specific Immune Function After digesting a pathogen,present antigen ...
... 2. Perform Specific Immune Function After digesting a pathogen,present antigen ...
Chapter 16
... • Basophils: Produce histamine • Eosinophils: Toxic to parasites, some phagocytosis • Monocytes: Phagocytic as mature macrophages • Fixed macrophages in lungs, liver, bronchi • Wandering macrophages roam tissues • Lymphocytes: Involved in specific immunity ...
... • Basophils: Produce histamine • Eosinophils: Toxic to parasites, some phagocytosis • Monocytes: Phagocytic as mature macrophages • Fixed macrophages in lungs, liver, bronchi • Wandering macrophages roam tissues • Lymphocytes: Involved in specific immunity ...
Inflammation 5
... Lymphocytes and Plasma Cells • Lymphocytes and macrophages interact in a bidirectional way, and these interactions play an important role in chronic inflammation • Activated T lymphocytes produce cytokines, including IFN-γ, a powerful activator of macrophages, ...
... Lymphocytes and Plasma Cells • Lymphocytes and macrophages interact in a bidirectional way, and these interactions play an important role in chronic inflammation • Activated T lymphocytes produce cytokines, including IFN-γ, a powerful activator of macrophages, ...
PP Chapter 21 P I
... viruses to protect other cells which have not been infected. – Stimulate synthesis of PKR protein that interfers with vial replication in healthy cells – Lymphocytes secrete gamma interferon; leukocytes secrete alpha interferon – Also can activate NK cells and macrophages which have anti-cancer capa ...
... viruses to protect other cells which have not been infected. – Stimulate synthesis of PKR protein that interfers with vial replication in healthy cells – Lymphocytes secrete gamma interferon; leukocytes secrete alpha interferon – Also can activate NK cells and macrophages which have anti-cancer capa ...
Ch6-Immune Desease
... Major Histocompatibility Complex • A genetic “LOCUS” on Chromosome 6, which codes for cell surface compatibility • Also called HLA (Human Leukocyte Antigens) in humans and H-2 in mice • It’s major job is to make sure all self cell antigens are recognized and “tolerated”, because the general rule of ...
... Major Histocompatibility Complex • A genetic “LOCUS” on Chromosome 6, which codes for cell surface compatibility • Also called HLA (Human Leukocyte Antigens) in humans and H-2 in mice • It’s major job is to make sure all self cell antigens are recognized and “tolerated”, because the general rule of ...
Chapter 6 - Medical School Pathology
... Major Histocompatibility Complex • A genetic “LOCUS” on Chromosome 6, which codes for cell surface compatibility • Also called HLA (Human Leukocyte Antigens) in humans and H-2 in mice • It’s major job is to make sure all self cell antigens are recognized and “tolerated”, because the general rule of ...
... Major Histocompatibility Complex • A genetic “LOCUS” on Chromosome 6, which codes for cell surface compatibility • Also called HLA (Human Leukocyte Antigens) in humans and H-2 in mice • It’s major job is to make sure all self cell antigens are recognized and “tolerated”, because the general rule of ...
IMMUNITY MEDIATED BY B LYMPHOCYTES AND ANTIBODIES
... THE INNATE IMMUNE SYSTEM * First line of defense against pathogens * Components ...
... THE INNATE IMMUNE SYSTEM * First line of defense against pathogens * Components ...
21.4. Bacterial Infections of the Lower Respiratory System
... – Seen on X-rays as Ghon foci – Called Ghon complex if adjacent lymph nodes involved ...
... – Seen on X-rays as Ghon foci – Called Ghon complex if adjacent lymph nodes involved ...
Diseases of the Immune System lec.3
... Natural History and Clinical Course Three phases reflecting the dynamics of virus–host interaction can be recognized: (1) an early acute phase, (2) a middle chronic phase, and (3) a final crisis phase The acute phase represents the initial response of an immunocompetent adult to HIV infection. Clini ...
... Natural History and Clinical Course Three phases reflecting the dynamics of virus–host interaction can be recognized: (1) an early acute phase, (2) a middle chronic phase, and (3) a final crisis phase The acute phase represents the initial response of an immunocompetent adult to HIV infection. Clini ...
Lymphatic System - Sizemore's Site
... Also called innate defense Do not distinguish one type of threat from another. Present at birth Includes physical barriers (skin, mucous membranes), phagocytic cells, interferons, complement, inflammation, and fever. ...
... Also called innate defense Do not distinguish one type of threat from another. Present at birth Includes physical barriers (skin, mucous membranes), phagocytic cells, interferons, complement, inflammation, and fever. ...
Resisting infection Cellular Defenses: Leukocytes
... • In blood: monocytes • Monocytes mature into macrophages, which reside in the tissues • Can destroy larger particles/debris ...
... • In blood: monocytes • Monocytes mature into macrophages, which reside in the tissues • Can destroy larger particles/debris ...
TARGET: TUMOR MICROENVIRONMENT Study led by Ludwig
... how it might be overcome A number of cancer therapies under development target not the malignant cells themselves but the cells and biomolecules they hijack to survive and thrive. Until now, however, it's been unclear whether a cancer's biochemical environment and cellular support crew— collectively ...
... how it might be overcome A number of cancer therapies under development target not the malignant cells themselves but the cells and biomolecules they hijack to survive and thrive. Until now, however, it's been unclear whether a cancer's biochemical environment and cellular support crew— collectively ...
IN RESPONSE TO DAMAGE Innate, or nonspecific, immunity
... .. secrete signals to decrease blood flow right at the wound (so you don't bleed to death) but increase blood flow and capillary permeability nearby to allow phagocytes to be able to enter the interstitial fluid near the wound .. Macrophage - "big eaters" .. phagocytize just about anything .. posses ...
... .. secrete signals to decrease blood flow right at the wound (so you don't bleed to death) but increase blood flow and capillary permeability nearby to allow phagocytes to be able to enter the interstitial fluid near the wound .. Macrophage - "big eaters" .. phagocytize just about anything .. posses ...
01_innate - WordPress.com
... • Non-specific (not antigen specific) receptor recognition • Part of innate antimicrobial defense • Toll-like receptors on macrophages bind pathogen and cause activation ...
... • Non-specific (not antigen specific) receptor recognition • Part of innate antimicrobial defense • Toll-like receptors on macrophages bind pathogen and cause activation ...
Fermentative Production of Natural and Unnatural Flavonoids by
... including non-tuberculous mycobacteria (NTM). One NTM species, Mycobacterium abscessus (formerly Mycobacterium chelonae subsp. abscessus), is a rapidly growing mycobacterium that causes a wide spectrum of human diseases, including chronic lung diseases, and disseminated infections in patients under ...
... including non-tuberculous mycobacteria (NTM). One NTM species, Mycobacterium abscessus (formerly Mycobacterium chelonae subsp. abscessus), is a rapidly growing mycobacterium that causes a wide spectrum of human diseases, including chronic lung diseases, and disseminated infections in patients under ...
Innate Immunity - microbiology and immunology on-line
... Antigen presentation for specific immune ...
... Antigen presentation for specific immune ...
Ref. Infectious agents or immunomodulatory molecules Host cell
... variety of live bacteria and bacterial cell components [1]. The macrophages were exposed to the infectious agent or component for twenty-four hours, and four to five time-points were collected. Organisms included representative species from the major classes of human bacterial pathogens: Gram-positi ...
... variety of live bacteria and bacterial cell components [1]. The macrophages were exposed to the infectious agent or component for twenty-four hours, and four to five time-points were collected. Organisms included representative species from the major classes of human bacterial pathogens: Gram-positi ...
Immune System Disorders
... Autograft: Use of one's own tissue Isograft: Use of identical twin's tissue Allograft: Use of tissue from another person Xenotransplantation product: Use of nonhuman tissue Graft-versus-host disease can result from transplanted bone marrow that contains immunocompetent cells ...
... Autograft: Use of one's own tissue Isograft: Use of identical twin's tissue Allograft: Use of tissue from another person Xenotransplantation product: Use of nonhuman tissue Graft-versus-host disease can result from transplanted bone marrow that contains immunocompetent cells ...
Bacterial Disease in Humans
... • Other macrophages diffuse from peripheral blood, phagocytose TB and are inactivated, rendering them unable to destroy TB. ...
... • Other macrophages diffuse from peripheral blood, phagocytose TB and are inactivated, rendering them unable to destroy TB. ...
Chapter 35 Immunity
... 5. _________________ is/are a series of enzymes activated in a sequence as a response to invading organisms. A. Complement b. Lysozymes c. A major histocompatibility complex d. Interferons e. Tumor necrosis factors ...
... 5. _________________ is/are a series of enzymes activated in a sequence as a response to invading organisms. A. Complement b. Lysozymes c. A major histocompatibility complex d. Interferons e. Tumor necrosis factors ...
ninth lecture
... The complex C4b2a is known as C3 convertase. It cleaves C3 into C3a (with anaphylatoxic and chemotactic activity) and C3b (with opsonic activity). The interaction of C3b with C4b2a bound to the cell membrane produces C4b3b2a which is termed C5 convertase and initiates the final lytic pathway involvi ...
... The complex C4b2a is known as C3 convertase. It cleaves C3 into C3a (with anaphylatoxic and chemotactic activity) and C3b (with opsonic activity). The interaction of C3b with C4b2a bound to the cell membrane produces C4b3b2a which is termed C5 convertase and initiates the final lytic pathway involvi ...
Macrophage
Macrophages (Greek: big eaters, from makros ""large"" + phagein ""eat""; abbr. MΦ) are a type of white blood cell that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the types of proteins specific to the surface of healthy body cells on its surface in a process called phagocytosis. Macrophages were first discovered by Élie Metchnikoff, a Russian bacteriologist, in 1884. They are found in essentially all tissues, where they patrol for potential pathogens by amoeboid movement. They play a critical role in non-specific defense (innate immunity), and also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes. In humans, dysfunctional macrophages cause severe diseases such as chronic granulomatous disease that result in frequent infections.Beyond increasing inflammation and stimulating the immune system, macrophages also play an important anti-inflammatory role and can decrease immune reactions through the release of cytokines. Macrophages that encourage inflammation are called M1 macrophages, whereas those that decrease inflammation and encourage tissue repair are called M2 macrophages. This difference is reflected in their metabolism, M1 macrophages have the unique ability to metabolize arginine to the ""killer"" molecule nitric oxide, whereas M2 macrophages have the unique ability to metabolize arginine to the ""repair"" molecule ornithine.Human macrophages are about 21 micrometres (0.00083 in) in diameter and are produced by the differentiation of monocytes in tissues. They can be identified using flow cytometry or immunohistochemical staining by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68.