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Rhesus ALK-7 / ALK7 / ACVR1C Protein (Fc Tag)
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... < 1.0 EU per μg of the protein as determined by the LAL method ...
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... Oysters are one of the most important commercially exploited species cultured in the molluskan hatcheries around the world. Due to rising CO 2 and subsequent decrease in seawater pH, their survival and shell forming processes are threatened globally. Our large-scale CO 2 perturbation experiments at ...
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Center for Structural Biology
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The samples were dissolved in 25 µL of 100 mM ammonium
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... Describe the relationship between genes, nucleic acids, amino acids, and proteins. DNA is a specific nucleic acid that directs protein making in all living things Proteins function in a variety of critical ways in living things not the least of which is to serve as enzymes that catalyze numerous and ...
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... Presently, several databases containing empirically derived tandem mass spectrum (MS/MS) data are publicly available. These can be used singly or in a concatenated fashion; together they contain the sequences of more than 12 million proteins. We have imported these into the Illinois Bio-Grid Mass Sp ...
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Introductory Signposting - Oklahoma State University

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Protein mass spectrometry



Protein mass spectrometry refers to the application of mass spectrometry to the study of proteins. Mass spectrometry is an important emerging method for the characterization of proteins. The two primary methods for ionization of whole proteins are electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI). In keeping with the performance and mass range of available mass spectrometers, two approaches are used for characterizing proteins. In the first, intact proteins are ionized by either of the two techniques described above, and then introduced to a mass analyzer. This approach is referred to as ""top-down"" strategy of protein analysis. In the second, proteins are enzymatically digested into smaller peptides using a protease such as trypsin. Subsequently these peptides are introduced into the mass spectrometer and identified by peptide mass fingerprinting or tandem mass spectrometry. Hence, this latter approach (also called ""bottom-up"" proteomics) uses identification at the peptide level to infer the existence of proteins.Whole protein mass analysis is primarily conducted using either time-of-flight (TOF) MS, or Fourier transform ion cyclotron resonance (FT-ICR). These two types of instrument are preferable here because of their wide mass range, and in the case of FT-ICR, its high mass accuracy. Mass analysis of proteolytic peptides is a much more popular method of protein characterization, as cheaper instrument designs can be used for characterization. Additionally, sample preparation is easier once whole proteins have been digested into smaller peptide fragments. The most widely used instrument for peptide mass analysis are the MALDI time-of-flight instruments as they permit the acquisition of peptide mass fingerprints (PMFs) at high pace (1 PMF can be analyzed in approx. 10 sec). Multiple stage quadrupole-time-of-flight and the quadrupole ion trap also find use in this application.
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