2. Midorine - GEOCITIES.ws
... every drug in pharmaceutical purpose is designed by depending on organic compounds. For this reason, the importance of organic compounds in pharmaceutical fields is enormous. The great majority of today’s new basic drugs are distinct organic chemical compounds. Most of these are products of syntheti ...
... every drug in pharmaceutical purpose is designed by depending on organic compounds. For this reason, the importance of organic compounds in pharmaceutical fields is enormous. The great majority of today’s new basic drugs are distinct organic chemical compounds. Most of these are products of syntheti ...
Title: Directly observable behavioral effects of lorcaserin in rats
... other behavioral effects in rats. For example, the prototypical 5-HT2C receptor agonist mCPP induces yawning and penile erections (Protais et al., 1995; Kennett and Curzon, 1988). In addition to 5-HT2C receptors, lorcaserin also has affinity for other 5-HT receptor subtypes, including 5-HT2A, 5-HT2B ...
... other behavioral effects in rats. For example, the prototypical 5-HT2C receptor agonist mCPP induces yawning and penile erections (Protais et al., 1995; Kennett and Curzon, 1988). In addition to 5-HT2C receptors, lorcaserin also has affinity for other 5-HT receptor subtypes, including 5-HT2A, 5-HT2B ...
Androgenic alopecia, commonly called male pattern baldness
... stretching of hirsute scalp is another surgical technique, sometimes used in conjunction with transplantation. But there is pain, inconvenience, and cost. One oral drug, finasteride, was approved a few years ago for men only. The 5-alpha-reductase inhibitor arrests hair loss by reducing DHT produced ...
... stretching of hirsute scalp is another surgical technique, sometimes used in conjunction with transplantation. But there is pain, inconvenience, and cost. One oral drug, finasteride, was approved a few years ago for men only. The 5-alpha-reductase inhibitor arrests hair loss by reducing DHT produced ...
Pharmacology of anabolic steroids
... With structural modifications to testosterone, the anabolic effects of androgens can be enhanced but, even so, these cannot be divorced entirely from their androgenic effects. Hence, a more accurate term for anabolic steroids is anabolic–androgenic steroids, but, for simplicity, the shorter term is ...
... With structural modifications to testosterone, the anabolic effects of androgens can be enhanced but, even so, these cannot be divorced entirely from their androgenic effects. Hence, a more accurate term for anabolic steroids is anabolic–androgenic steroids, but, for simplicity, the shorter term is ...
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... Gynecomastia may develop and persist in patients being treated with androgens, including ANDRODERM, for hypogonadism. ...
... Gynecomastia may develop and persist in patients being treated with androgens, including ANDRODERM, for hypogonadism. ...
Saw Palmetto - Judith Volpe MD
... obstructing urine flow. Some studies suggest that saw palmetto helps to ease urine flow by reducing the prostate's pressure against the urethra. Other studies have been less conclusive, so there are still some major information gaps in what we know about how it affects the prostate. Regardless, saw ...
... obstructing urine flow. Some studies suggest that saw palmetto helps to ease urine flow by reducing the prostate's pressure against the urethra. Other studies have been less conclusive, so there are still some major information gaps in what we know about how it affects the prostate. Regardless, saw ...
cytochrome p450 2w1 (cyp2w1) as a novel drug target in colon
... Colon cancer (colorectal cancer, CRC) is the third most frequently diagnosed malignancy in the world. The annual incidence is estimated to be around one million, while more than 500,000 patients die from the disease each year. Colon cancer is predominantly diagnosed in W ...
... Colon cancer (colorectal cancer, CRC) is the third most frequently diagnosed malignancy in the world. The annual incidence is estimated to be around one million, while more than 500,000 patients die from the disease each year. Colon cancer is predominantly diagnosed in W ...
CURRICULUM VITAE - University of Oxford
... definition of pathways of differentiation control, and so enable a much finer classification of CRCs through identification of the relevant differentiation controlling gene functions that are altered in any given cancer. There is now abundant evidence that, for many cancers, cell lines are good repr ...
... definition of pathways of differentiation control, and so enable a much finer classification of CRCs through identification of the relevant differentiation controlling gene functions that are altered in any given cancer. There is now abundant evidence that, for many cancers, cell lines are good repr ...
Novartis Award for Hypertension Research Reconsidering the Roles
... shown to be responsive to aldosterone, at both the genomic and nongenomic levels,24,25 for which the latter response is presumably invoked after the rapid secretion of aldosterone on orthostasis. In the brain, MR in the AV3V region of the hypothalamus have been shown experimentally to respond to int ...
... shown to be responsive to aldosterone, at both the genomic and nongenomic levels,24,25 for which the latter response is presumably invoked after the rapid secretion of aldosterone on orthostasis. In the brain, MR in the AV3V region of the hypothalamus have been shown experimentally to respond to int ...
Structure-based development of target
... binding of TF VIIa to a cell surface TF that, in the case of disease state or during injury, can lead to thrombus formation. Parlow et al. [40] have used the crystal structure of TF VIIa to design inhibitors that have improved inhibitor potency and selectivity by designing a library containing a ser ...
... binding of TF VIIa to a cell surface TF that, in the case of disease state or during injury, can lead to thrombus formation. Parlow et al. [40] have used the crystal structure of TF VIIa to design inhibitors that have improved inhibitor potency and selectivity by designing a library containing a ser ...
Evidence document - UK Government Web Archive
... single disease entity but more a spectrum of diseases, ranging from slow-growing tumours, which may not cause any symptoms or shorten life, to very aggressive tumours (see section 3.4 for staging procedures). Some tumours can change from being low risk to high risk. Many men with slow-growing tumour ...
... single disease entity but more a spectrum of diseases, ranging from slow-growing tumours, which may not cause any symptoms or shorten life, to very aggressive tumours (see section 3.4 for staging procedures). Some tumours can change from being low risk to high risk. Many men with slow-growing tumour ...
Heart Failure
... stress during systole •Also has moderate direct positive inotropic activity independent of its afterload reducing effects •Reduces renal vascular resistance and increases renal blood flow •Increases renal blood flow more than any other vasodilator except ACE inhibitors •Preferred drug in CHF (ACE in ...
... stress during systole •Also has moderate direct positive inotropic activity independent of its afterload reducing effects •Reduces renal vascular resistance and increases renal blood flow •Increases renal blood flow more than any other vasodilator except ACE inhibitors •Preferred drug in CHF (ACE in ...
Human cancer cell lines - Journal of Chemical and Pharmaceutical
... plus 5-Fluorouracil (5-FU) on proliferation of two different types of gastric cancer cell lines (MKN28, KATOIII) using the WST-1 method was investigated suggest that the anti-proliferative effects of tamoxifen plus 5-FU on KATOIII cells were not dependent on estrogen receptor expression or TGF-b1 se ...
... plus 5-Fluorouracil (5-FU) on proliferation of two different types of gastric cancer cell lines (MKN28, KATOIII) using the WST-1 method was investigated suggest that the anti-proliferative effects of tamoxifen plus 5-FU on KATOIII cells were not dependent on estrogen receptor expression or TGF-b1 se ...
External Beam Radiotherapy for Prostate Cancer Patient Information
... as well as the areas surrounding the gland. High energy x-ray beams are directed at the prostate from outside the body. These beams damage the cancer cells and stop them from dividing and growing. The cancer cells are not able to recover from this damage and subsequently die. However, the normal hea ...
... as well as the areas surrounding the gland. High energy x-ray beams are directed at the prostate from outside the body. These beams damage the cancer cells and stop them from dividing and growing. The cancer cells are not able to recover from this damage and subsequently die. However, the normal hea ...
Hit-to-lead (H2L) and Lead Optimization in Medicinal Chemistry
... • on-rate affected by diffusion, desolvation, molecular orbital reorientation… • difficult to impact by design • SAR would be entirely empirically driven • on-rate may not be a limiting factor of the P-L complex formation in vivo ...
... • on-rate affected by diffusion, desolvation, molecular orbital reorientation… • difficult to impact by design • SAR would be entirely empirically driven • on-rate may not be a limiting factor of the P-L complex formation in vivo ...
Prostate cancer (radical prostatectomy) structured reporting protocol
... rational planning of patient management and is a major component of the most common nomograms used to guide clinical decision making.10 Likewise, accurate data from the pathological examination of radical prostatectomy specimens is essential in predicting the risk of cancer recurrence after prostate ...
... rational planning of patient management and is a major component of the most common nomograms used to guide clinical decision making.10 Likewise, accurate data from the pathological examination of radical prostatectomy specimens is essential in predicting the risk of cancer recurrence after prostate ...
Induction and Maintenance Therapy
... transplantation performed induction therapy using antithymocyte globulins (ATG) while the others used basiliximab [18]. The results in terms of efficacy for basiliximab are on par with ATG in recipients with low risk of acute rejection, but it has less success with higher-risk patients. However, it ...
... transplantation performed induction therapy using antithymocyte globulins (ATG) while the others used basiliximab [18]. The results in terms of efficacy for basiliximab are on par with ATG in recipients with low risk of acute rejection, but it has less success with higher-risk patients. However, it ...
A Comparative Study of Diane-35 plus Spironolactone and Diane
... Spironolactone is an antiandrogen which competes with dihydrotestosterone (DHT) for androgen receptors in the skin. It also increases the metabolic clearance of testosterone and inhibits androgen production.5 Hyperkalemia may occur in patient on Spironolactone treatment. Another antiandrogen, finast ...
... Spironolactone is an antiandrogen which competes with dihydrotestosterone (DHT) for androgen receptors in the skin. It also increases the metabolic clearance of testosterone and inhibits androgen production.5 Hyperkalemia may occur in patient on Spironolactone treatment. Another antiandrogen, finast ...
UCResearchPstr_Red_48x36
... Benzodiazepines are able to enhance ligand binding to the GABA(A) receptor through allosteric activation. This class of drug, however, is non-selective in binding to the different subunits that can comprise the receptor. This means that in addition to the anxiolytic effects attributed to modulation ...
... Benzodiazepines are able to enhance ligand binding to the GABA(A) receptor through allosteric activation. This class of drug, however, is non-selective in binding to the different subunits that can comprise the receptor. This means that in addition to the anxiolytic effects attributed to modulation ...
Histamine receptor antagonists
... H1 receptors. Patients with asthma are very sensitive to histamine. The ...
... H1 receptors. Patients with asthma are very sensitive to histamine. The ...
Release of norepinephrine: Removal of norepinephrine:
... affinities for adrenergic agonists and antagonists. β 1 Receptors have approximately equal affinities for epinephrine and norepinephrine, whereas β 2 receptors have a higher affinity for epinephrine than for norepinephrine. Thus, tissues with a predominance of β 2 receptors (such as the vasculature ...
... affinities for adrenergic agonists and antagonists. β 1 Receptors have approximately equal affinities for epinephrine and norepinephrine, whereas β 2 receptors have a higher affinity for epinephrine than for norepinephrine. Thus, tissues with a predominance of β 2 receptors (such as the vasculature ...
Treatment of Cough
... 3. It can be divided into 2 types a. Productive cough – with phlegm b. Non – productive (Dry) cough – without phlegm ...
... 3. It can be divided into 2 types a. Productive cough – with phlegm b. Non – productive (Dry) cough – without phlegm ...
Beta-lactam antibiotics
... of the face, neck and trunk, a reaction which occurs during the infusion, and may be associated with hypotension. Nephrotoxicity and ototoxicity may occur in < 1% of pts especially those receiving other "toxic' drugs like aminoglycosides. A relationship between vancomycin level and nephrotoxicity or ...
... of the face, neck and trunk, a reaction which occurs during the infusion, and may be associated with hypotension. Nephrotoxicity and ototoxicity may occur in < 1% of pts especially those receiving other "toxic' drugs like aminoglycosides. A relationship between vancomycin level and nephrotoxicity or ...
Toxicant – Receptor Interactions: Fundamental - UNC
... context, the term refers to macromolecules (intracellular or cell surface) that recognize endogenous ligands; these ligands may be small (e.g., neurotransmitters, hormones, autacoids) or large (e.g., proteins involved in protein sorting or in intracellular scaffolding). In toxicology and pharmacolog ...
... context, the term refers to macromolecules (intracellular or cell surface) that recognize endogenous ligands; these ligands may be small (e.g., neurotransmitters, hormones, autacoids) or large (e.g., proteins involved in protein sorting or in intracellular scaffolding). In toxicology and pharmacolog ...
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.