![Intra-articular injection of morphine: may it play a role? Serbülent](http://s1.studyres.com/store/data/002256513_1-dcd197b3e3377058c4ac9db99e7c1a87-300x300.png)
Kinetic analysis of drug-target interactions with
... usually the starting point for pharmacokinetic characterization, in vivo conditions such as the presence of endogenous ligands, local ionic environments, receptor clustering, and ligand rebinding effects are difficult to reproduce in vitro leading to uncertainty around these estimates. Furthermore, ...
... usually the starting point for pharmacokinetic characterization, in vivo conditions such as the presence of endogenous ligands, local ionic environments, receptor clustering, and ligand rebinding effects are difficult to reproduce in vitro leading to uncertainty around these estimates. Furthermore, ...
Testosterone and anabolic steroids
... drive, impotence, and loss of facial or body hair. This condition is called hypogonadism. Hormone replacement therapy with synthetic testosterone may help to relieve those symptoms. HIV-positive women may also develop low testosterone levels and experience symptoms of fatigue, loss of sex drive, and ...
... drive, impotence, and loss of facial or body hair. This condition is called hypogonadism. Hormone replacement therapy with synthetic testosterone may help to relieve those symptoms. HIV-positive women may also develop low testosterone levels and experience symptoms of fatigue, loss of sex drive, and ...
Chronic Heroin Self-Administration Desensitizes Opioid Receptor
... tolerance and dependence remains unclear. Opioid receptors belong to the family of inhibitory G-protein-coupled receptors (Evans et al., 1992; Kieffer et al., 1992; Chen et al., 1993; Thompson et al., 1993), and chronic opiate exposure in cultured cell lines results in desensitization followed by re ...
... tolerance and dependence remains unclear. Opioid receptors belong to the family of inhibitory G-protein-coupled receptors (Evans et al., 1992; Kieffer et al., 1992; Chen et al., 1993; Thompson et al., 1993), and chronic opiate exposure in cultured cell lines results in desensitization followed by re ...
Drugs acting on the uterus
... Ergot alkaloids are contraindicated to be used as inducers to delivery (associated with high incidence of fetal distress and mortality) ...
... Ergot alkaloids are contraindicated to be used as inducers to delivery (associated with high incidence of fetal distress and mortality) ...
Opioid Pharmacology Definitions 1. Opium – a mixture of alkaloids
... Each receptor thought to have 2-3 (or more) subtypes, but no distinct gene products have been identified. All belong to the superfamily of G-protein coupled receptors. ...
... Each receptor thought to have 2-3 (or more) subtypes, but no distinct gene products have been identified. All belong to the superfamily of G-protein coupled receptors. ...
MACROLIDES Macrolide antibiotics contain a many membered
... preventing initiation complex formation . • Binding site is unique so cross-resistance doesn’t occur. ...
... preventing initiation complex formation . • Binding site is unique so cross-resistance doesn’t occur. ...
Whole-Animal Selection of Aptamers Targeting Murine Spinal Cord
... spleen was unable to be processed in this round. CT values for this tissue panel range from 27.62 to 29.71, which are higher than the mean CT observed for spinal cord tissue (25.56). This lead us to believe that the G3 aptamer library targeted the spinal cord tissue with more specificity than the ba ...
... spleen was unable to be processed in this round. CT values for this tissue panel range from 27.62 to 29.71, which are higher than the mean CT observed for spinal cord tissue (25.56). This lead us to believe that the G3 aptamer library targeted the spinal cord tissue with more specificity than the ba ...
Morphine
... f. Emesis: Morphine directly stimulates the chemoreceptor trigger zone in the area postrema that causes vomiting. g. GI tract: Morphine relieves diarrhea by decreasing the motility and increasing the tone of the intestinal circular smooth muscle. Morphine also increases the tone of the anal sphincte ...
... f. Emesis: Morphine directly stimulates the chemoreceptor trigger zone in the area postrema that causes vomiting. g. GI tract: Morphine relieves diarrhea by decreasing the motility and increasing the tone of the intestinal circular smooth muscle. Morphine also increases the tone of the anal sphincte ...
Electrosurgical transurethral resection of the prostate and
... Multiple techniques have been described for TURP originating with Nesbit in 1943.3 A four step approach was then characterized and later modified by May and Hartung.4,5 This technique begins with resection at the proximal portion of the middle lobe at the 6 o’clock position. With the resectoscope pl ...
... Multiple techniques have been described for TURP originating with Nesbit in 1943.3 A four step approach was then characterized and later modified by May and Hartung.4,5 This technique begins with resection at the proximal portion of the middle lobe at the 6 o’clock position. With the resectoscope pl ...
Insulin-like Growth Factor: Current Concepts and New
... assays and methods used in analysis. Interestingly, these variations may aid in selection of patients who would benefit most from IGF-targeted therapy and biomarker development. 1.4. Receptor Cross-Talk Receptor cross-talk can occur through ligand interactions or common downstream molecular pathways ...
... assays and methods used in analysis. Interestingly, these variations may aid in selection of patients who would benefit most from IGF-targeted therapy and biomarker development. 1.4. Receptor Cross-Talk Receptor cross-talk can occur through ligand interactions or common downstream molecular pathways ...
In vivo imaging of dopamine and serotonin release Udo de
... the radioligand and vice versa (Dewey et al. 1993; Laruelle 2000). The exact mechanism for these changes in receptor availability is not known. The changes may be a result of true competition between DA and the injected ligand, but may also be due to DA-induced internalization of the receptor (Sun e ...
... the radioligand and vice versa (Dewey et al. 1993; Laruelle 2000). The exact mechanism for these changes in receptor availability is not known. The changes may be a result of true competition between DA and the injected ligand, but may also be due to DA-induced internalization of the receptor (Sun e ...
A humanized monoclonal antibody to carcinoembryonic antigen
... day 37, 87% of the tumors treated with labetuzumab were <0.5 cm3 compared with 40% of the untreated group and 29% of the epratuzumab-treated group. t Test analysis of the area under the growth curves showed significant differences (P < 0.05) between the untreated group and the groups treated with ei ...
... day 37, 87% of the tumors treated with labetuzumab were <0.5 cm3 compared with 40% of the untreated group and 29% of the epratuzumab-treated group. t Test analysis of the area under the growth curves showed significant differences (P < 0.05) between the untreated group and the groups treated with ei ...
Pharm of the Adrenal Cortex
... Circulating aldosterone binds w/low affinity to transcortin (aka corticotropin binding globulin), and a specific mineralocorticoid binding protein o 50-60% of circulating aldosterone is bound to transport proteins, elimination half-life: 20 minutes o orally administered aldosterone – high first pa ...
... Circulating aldosterone binds w/low affinity to transcortin (aka corticotropin binding globulin), and a specific mineralocorticoid binding protein o 50-60% of circulating aldosterone is bound to transport proteins, elimination half-life: 20 minutes o orally administered aldosterone – high first pa ...
Megace - Bristol
... megestrol acetate metabolites and is, therefore, non-specific and indicates higher concentrations ...
... megestrol acetate metabolites and is, therefore, non-specific and indicates higher concentrations ...
OPIATE ANALGESICS AND ANTAGONISTS
... when given parenterally due to first-pass metabolism in the liver. - Metabolism involves glucuronide formation, the product of which is excreted in the urine. • 1. Central Nervous System Effects • Morphine has mixed depressant and stimulatory actions on the CNS. - depressant effects predominate in m ...
... when given parenterally due to first-pass metabolism in the liver. - Metabolism involves glucuronide formation, the product of which is excreted in the urine. • 1. Central Nervous System Effects • Morphine has mixed depressant and stimulatory actions on the CNS. - depressant effects predominate in m ...
alkaloid discovery as natural acetylcholinesterase
... Acetylcholinesterase (AChE), plays a key role as an essential enzyme in memory and cognition process trough the hydrolysis of neurotransmitter acetylcholine. Although the physiological role of AChE in neural transmission is well known, its role as pharmaceutical target for the treatment of Alzheimer ...
... Acetylcholinesterase (AChE), plays a key role as an essential enzyme in memory and cognition process trough the hydrolysis of neurotransmitter acetylcholine. Although the physiological role of AChE in neural transmission is well known, its role as pharmaceutical target for the treatment of Alzheimer ...
... similarity to mianserin, an antidepressant drug with antihistamine and 5-HT2 antagonistic properties [1]. Epinastine was originally introduced as an antihistamine drug without sedative side-effects on the central nervous system, due to favourable physicochemical properties. Its low lipophilicity and ...
Prostatitis - Specialized Urologic Consultants
... The PSA levels can be falsely elevated by prostatitis. If a patient has an elevated PSA, along with finding of prostatitis, we encourage treatment and a repeat of the blood tests. Many patients with chronic prostatitis will undergo prostate biopsies because their PSA values are too high. The biopsy ...
... The PSA levels can be falsely elevated by prostatitis. If a patient has an elevated PSA, along with finding of prostatitis, we encourage treatment and a repeat of the blood tests. Many patients with chronic prostatitis will undergo prostate biopsies because their PSA values are too high. The biopsy ...
Cancer treatment in the Arab-Islamic medicine: Integration of
... extra mass of cells with abnormalities in their DNA. Tumors may be benign (not cancer), or malignant (cancer). Among many others, the causes of cancer might be tobacco smoke, infection, chemicals, radiation, environmental factors, and unhealthy diet (Figure 1). In addition to uncontrolled cell proli ...
... extra mass of cells with abnormalities in their DNA. Tumors may be benign (not cancer), or malignant (cancer). Among many others, the causes of cancer might be tobacco smoke, infection, chemicals, radiation, environmental factors, and unhealthy diet (Figure 1). In addition to uncontrolled cell proli ...
drugs in Dyslipidaemias
... • Pain / tenderness, weakness • ↑ CK > 10 times upper limit of normal • Reversible • ↑ risk with concurrent fibrate therapy, hypothyroidism, renal insufficiency ...
... • Pain / tenderness, weakness • ↑ CK > 10 times upper limit of normal • Reversible • ↑ risk with concurrent fibrate therapy, hypothyroidism, renal insufficiency ...
Promising Therapies for Treating and/or Preventing Androgenic
... session and sometimes more depending on the number of grafts and the surgeon. One or two sessions may be required depending on the extent of hair loss. Surgical treatment is limited by the hair density in the donor region and the reluctance of some patients to undergo what is a fairly invasive proce ...
... session and sometimes more depending on the number of grafts and the surgeon. One or two sessions may be required depending on the extent of hair loss. Surgical treatment is limited by the hair density in the donor region and the reluctance of some patients to undergo what is a fairly invasive proce ...
High-dose antipsychotic medication
... al, 1987;Mehtonenef al, 1991)for which antipsychotic drugs have been blamed. In the latter study, from Finland, sudden deaths were associated with so-called low-potency drugs, such as the phenothiazines. It has been said that as many as 50 sudden deaths per year may be occurring in the UK among pati ...
... al, 1987;Mehtonenef al, 1991)for which antipsychotic drugs have been blamed. In the latter study, from Finland, sudden deaths were associated with so-called low-potency drugs, such as the phenothiazines. It has been said that as many as 50 sudden deaths per year may be occurring in the UK among pati ...
Session 4 Topics Need to Monitor Aspirin Therapy
... Prasugrel (Effient®) • Theinophyridine like clopidogrel • Prodrug metabolized to active metabolite in the liver by cytochrome system • Inhibits platelet function by irreversibly binding P2Y12 ADP platelet receptors • Appears to be unaffected by cytochrome polymorphisms that inhibit clopidogrel ...
... Prasugrel (Effient®) • Theinophyridine like clopidogrel • Prodrug metabolized to active metabolite in the liver by cytochrome system • Inhibits platelet function by irreversibly binding P2Y12 ADP platelet receptors • Appears to be unaffected by cytochrome polymorphisms that inhibit clopidogrel ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.