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Victorian Prostate Cancer Clinical Registry
... estimated 75–80% of the Victorian population through 33 different health services or clinics, enrolling now nearly 10,000 men. Our “pilot” worked: we have largely achieved what we set out to do in the initial 2009 proposal. We demonstrated the feasibility of an opt‐off populatio ...
... estimated 75–80% of the Victorian population through 33 different health services or clinics, enrolling now nearly 10,000 men. Our “pilot” worked: we have largely achieved what we set out to do in the initial 2009 proposal. We demonstrated the feasibility of an opt‐off populatio ...
Testosterone Effects on the Breast
... cell proliferation by 50% of the basal growth rate and counteracted estradiol-proliferative action by 68%. Normal circulating levels in women are approximately 0.5–2.3 nmol/ liter for testosterone, and 0.2– 0.8 nmol/liter for DHT. Thus, most of the concentrations for these hormones used in this and ...
... cell proliferation by 50% of the basal growth rate and counteracted estradiol-proliferative action by 68%. Normal circulating levels in women are approximately 0.5–2.3 nmol/ liter for testosterone, and 0.2– 0.8 nmol/liter for DHT. Thus, most of the concentrations for these hormones used in this and ...
IOSR Journal of Applied Physics (IOSR-JAP) e-ISSN: 2278-4861.
... inaccuracies during the treatment planning process. Various solutions can be chosen to detect and correct some of these four errors categories, but few solutions can be utilized to detect errors in all four categories. Several margin ‘recipes’ are described to calculate the CTV-PTV margin(5,6). Once ...
... inaccuracies during the treatment planning process. Various solutions can be chosen to detect and correct some of these four errors categories, but few solutions can be utilized to detect errors in all four categories. Several margin ‘recipes’ are described to calculate the CTV-PTV margin(5,6). Once ...
Androgenic anabolic steroids and arterial structure and function in
... male bodybuilders, the major findings were a decreased level of HDL cholesterol and a higher unadjusted LV mass in the steroid users, but no evidence of structural or functional abnormalities in the systemic arteries, compared to bodybuilding control subjects. Anabolic steroids and metabolism. Consi ...
... male bodybuilders, the major findings were a decreased level of HDL cholesterol and a higher unadjusted LV mass in the steroid users, but no evidence of structural or functional abnormalities in the systemic arteries, compared to bodybuilding control subjects. Anabolic steroids and metabolism. Consi ...
Targeting Microtubules by Natural Agents for Cancer Therapy
... Vinca rosea). These compounds have been successful in the clinic not only for the treatment of diabetes, high blood pressure, and as disinfectants, but also for being cancer fighters (26). Vinca alkaloids were discovered in the 1950s by Canadian scientists, Robert Noble and Charles Beer, for their a ...
... Vinca rosea). These compounds have been successful in the clinic not only for the treatment of diabetes, high blood pressure, and as disinfectants, but also for being cancer fighters (26). Vinca alkaloids were discovered in the 1950s by Canadian scientists, Robert Noble and Charles Beer, for their a ...
Angiotensin receptor blocker (arb) antihypertensive dose
... (ACEIs), and angiotensin receptor blockers (ARBs) represent 3 classes of drugs widely used in the treatment of. Each profile is a comprehensive review of the safety and effectiveness of this . If is not a Do Not Use product, information on adverse effects, drug. Greetings and Welcome to April 2017! ...
... (ACEIs), and angiotensin receptor blockers (ARBs) represent 3 classes of drugs widely used in the treatment of. Each profile is a comprehensive review of the safety and effectiveness of this . If is not a Do Not Use product, information on adverse effects, drug. Greetings and Welcome to April 2017! ...
Anti-androgenic Therapy Using Oral Spironolactone for Acne
... acutely elevated because androgen receptors are competitively blocked by the drug. The excessive testosterone could then be transformed into estradiol, which can induce endometrial hyperplasia and menstrual irregularities. Gynecomastia may be induced in males for the same reason [12]. Because the th ...
... acutely elevated because androgen receptors are competitively blocked by the drug. The excessive testosterone could then be transformed into estradiol, which can induce endometrial hyperplasia and menstrual irregularities. Gynecomastia may be induced in males for the same reason [12]. Because the th ...
leukotriene pathway inhibitors
... for beta-agonists and be at increased risk for asthma attacks, compared with those who do not use the drug at all. The second study shows that beta-agonist use increases cardiac risks, such as heart attacks, by more than twofold, compared with the use of a ...
... for beta-agonists and be at increased risk for asthma attacks, compared with those who do not use the drug at all. The second study shows that beta-agonist use increases cardiac risks, such as heart attacks, by more than twofold, compared with the use of a ...
Modelling and simulation to help define MABEL and Starting
... •Monkeys appear the most similar to humans for binding and in proliferation assay, Also observed with first generation compounds ...
... •Monkeys appear the most similar to humans for binding and in proliferation assay, Also observed with first generation compounds ...
FINASTERIDE (Propecia® / Proscar®) - EU
... Hamilton scale. Research has shown that finasteride can reduce the level of DHT in bald scalp. DHT is known to be the main cause of hair loss and is formed when the enzyme 5-alpha reductase interacts with the male hormone testosterone. Research also shows that finasteride generate little side effect ...
... Hamilton scale. Research has shown that finasteride can reduce the level of DHT in bald scalp. DHT is known to be the main cause of hair loss and is formed when the enzyme 5-alpha reductase interacts with the male hormone testosterone. Research also shows that finasteride generate little side effect ...
Pharm II - 2-22
... a. High potency typicals have a reduced risk of EPS b.Low potency typicals are less efficacious than higher potency antipsychotics c. Atypical antipsychotics have increased affinity for D2 as compared to typical antipsychotics d.Increased anticholinergic activity reduces the risk of EPS ...
... a. High potency typicals have a reduced risk of EPS b.Low potency typicals are less efficacious than higher potency antipsychotics c. Atypical antipsychotics have increased affinity for D2 as compared to typical antipsychotics d.Increased anticholinergic activity reduces the risk of EPS ...
Gaba - American College of Neuropsychopharmacology
... The classical benzodiazepines such as diazepam (Valium) have had a tremendous history in psychopharmacology, reaching tremendous sales, primarily for clinical anxiety (38, 43–45). Other uses of benzodiazepines include sedation, muscle relaxation, and a significant utilization for treatment of panic ...
... The classical benzodiazepines such as diazepam (Valium) have had a tremendous history in psychopharmacology, reaching tremendous sales, primarily for clinical anxiety (38, 43–45). Other uses of benzodiazepines include sedation, muscle relaxation, and a significant utilization for treatment of panic ...
Pellow, S., File, S.E. (1986). Anxiolytic and anxiogenic drug effects
... injection of cannabinoid CB1 receptor antagonist (AM251) in the presence of alpha-1 adrenergic antagonist (Prazosin) on rat behavior in the EPM. Materials and Methods: In the present study, the data were obtained from male Wistar rat, which weighing 200-250 g. Animal behavior in EPM were videotaped ...
... injection of cannabinoid CB1 receptor antagonist (AM251) in the presence of alpha-1 adrenergic antagonist (Prazosin) on rat behavior in the EPM. Materials and Methods: In the present study, the data were obtained from male Wistar rat, which weighing 200-250 g. Animal behavior in EPM were videotaped ...
Diphenhydramine (Benadryl)
... membrane to depolarize. This brings the neurons closer to their firing threshold potential, which causes an increase in the frequency of neuron firing. (Responsible for itching and pain response) ...
... membrane to depolarize. This brings the neurons closer to their firing threshold potential, which causes an increase in the frequency of neuron firing. (Responsible for itching and pain response) ...
Effector Pathway-Dependent Relative Efficacy at Serotonin Type 2A
... originally defined by Furchgott (1966), is a unique property of the drug, independent of the effector pathway through which drug activity is measured. Agonist relative efficacy [ratio of e of a test agonist to that of a reference agonist (eA/eAref)] must therefore also be effector pathway independen ...
... originally defined by Furchgott (1966), is a unique property of the drug, independent of the effector pathway through which drug activity is measured. Agonist relative efficacy [ratio of e of a test agonist to that of a reference agonist (eA/eAref)] must therefore also be effector pathway independen ...
INSILICO DRUG DESIGN AND MOLECULAR DOCKING STUDIES OF SOME NOVEL
... Objective: Cancer is a disease characterized by uncontrollable, irreversible, independent, autonomous, uncoordinated and relatively unlimited and abnormal over growth of tissues. Benzothiazole is an important class of heterocyclic compound which possess interesting biological activities like anti-tu ...
... Objective: Cancer is a disease characterized by uncontrollable, irreversible, independent, autonomous, uncoordinated and relatively unlimited and abnormal over growth of tissues. Benzothiazole is an important class of heterocyclic compound which possess interesting biological activities like anti-tu ...
Brachytherapy - Prostate Cancer Foundation of Australia
... LDR brachytherapy is generally a treatment for men with prostate cancer which is completely contained within the prostate gland. Placement of ‘seeds’ requires a procedure under anaesthetic that typically takes an hour or two. You may be able to have the treatment as a ‘day-only patient’ or be booked ...
... LDR brachytherapy is generally a treatment for men with prostate cancer which is completely contained within the prostate gland. Placement of ‘seeds’ requires a procedure under anaesthetic that typically takes an hour or two. You may be able to have the treatment as a ‘day-only patient’ or be booked ...
Subtype-selective GABAA receptor mimetics—novel
... systemic treatment, we tested as a proof-of-principle experiment the α1-sparing (non-sedative) partial benzodiazepinesite agonist L-838,417, which is an antagonist at the benzodiazepine binding site of GABAA receptor α1 subunits and a partial agonist at α2, α3, and α5 [20]. L-838,417 not only reduce ...
... systemic treatment, we tested as a proof-of-principle experiment the α1-sparing (non-sedative) partial benzodiazepinesite agonist L-838,417, which is an antagonist at the benzodiazepine binding site of GABAA receptor α1 subunits and a partial agonist at α2, α3, and α5 [20]. L-838,417 not only reduce ...
Reinforcing Effects of Psychostimulants in Humans Are Associated
... and Wise, 1977; Richardson et al., 1994; Self et al., 1996), its relevance in humans subjects, for whom its rewarding effects are associated with the subjective perception of pleasure or “high” (Fischman and Foltin, 1991), has not been investigated. It is also of importance to assess the role of DA ...
... and Wise, 1977; Richardson et al., 1994; Self et al., 1996), its relevance in humans subjects, for whom its rewarding effects are associated with the subjective perception of pleasure or “high” (Fischman and Foltin, 1991), has not been investigated. It is also of importance to assess the role of DA ...
2010 Breast Cancer Highlights, Breast Cancer Research Program
... Deleterious mutations in the BRCA2 gene predispose individuals to hereditary breast, ovarian, and other cancers, and lead to startling increases in lifetime cancer risk. For example, BRCA2 mutation carriers have a 56%-87% increase in breast cancer risk by age 70 compared to an 8% risk in the general ...
... Deleterious mutations in the BRCA2 gene predispose individuals to hereditary breast, ovarian, and other cancers, and lead to startling increases in lifetime cancer risk. For example, BRCA2 mutation carriers have a 56%-87% increase in breast cancer risk by age 70 compared to an 8% risk in the general ...
Title : Involvement of D1 dopamine receptor in
... mice MDMA induces behavioural changes and has rewarding effects but little is known about its cellular effects. We have previously shown that the ERK pathway is important for the changes in gene expression observed in mice striatum after treatment with this psychostimulant. In this study we investig ...
... mice MDMA induces behavioural changes and has rewarding effects but little is known about its cellular effects. We have previously shown that the ERK pathway is important for the changes in gene expression observed in mice striatum after treatment with this psychostimulant. In this study we investig ...
Pharmacologyonline 3: 7-22 (2011) Newsletter Tamboli et al.
... cervical ganglion (SCG) neurones when compared with different nicotinic agonists then cytisine was found to be the most potent agonist and lobeline the least potent. [19].However, several studies show that there is a large diversity of nicotinic receptor subtypes that differ in subunit composition a ...
... cervical ganglion (SCG) neurones when compared with different nicotinic agonists then cytisine was found to be the most potent agonist and lobeline the least potent. [19].However, several studies show that there is a large diversity of nicotinic receptor subtypes that differ in subunit composition a ...
DEVELOPMENT AND CHARACTERIZATION OF FLUTAMIDE CONTAINING SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)
... No Influence of Lipid Digestion Process. ...
... No Influence of Lipid Digestion Process. ...
mitoNEET as a novel drug target for mitochondrial dysfunction
... oncogenesis is an intriguing possibility [16]. Jennings and colleagues showed that mitoNEET plays an important part in the proliferation of breast cancer cells and tumor formation [41]. Taken together, this could explain the mechanism behind the observation that compounds that act as mitochondrial i ...
... oncogenesis is an intriguing possibility [16]. Jennings and colleagues showed that mitoNEET plays an important part in the proliferation of breast cancer cells and tumor formation [41]. Taken together, this could explain the mechanism behind the observation that compounds that act as mitochondrial i ...
Management of cancer treatment-induced bone loss in early breast
... inhibitor can indeed be observed in this animal model [17]. Exemestane is structurally related to androstenedione and its major metabolite, 17-hydro-exemestane, is androgenic as well, which probably explains these protective effects on bone. However, the use of much higher doses, on a weight for wei ...
... inhibitor can indeed be observed in this animal model [17]. Exemestane is structurally related to androstenedione and its major metabolite, 17-hydro-exemestane, is androgenic as well, which probably explains these protective effects on bone. However, the use of much higher doses, on a weight for wei ...
Discovery and development of antiandrogens
![](https://commons.wikimedia.org/wiki/Special:FilePath/Androgen_receptor.png?width=300)
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.