Calcium Channel Antagonists Inhibit Growth of Subcutaneous
... eningiomas are thought to arise from arachnoid cap cells found in the meninges and are one of the most common primary intracranial tumors found in adults [6]. Complete surgical removal is the most accepted treatment of intracranial meningiomas [1,9,31]. The medical condition of a patient, tumor recu ...
... eningiomas are thought to arise from arachnoid cap cells found in the meninges and are one of the most common primary intracranial tumors found in adults [6]. Complete surgical removal is the most accepted treatment of intracranial meningiomas [1,9,31]. The medical condition of a patient, tumor recu ...
曹永孝
... Glaucoma, especially angle-closure glaucoma, is a contraindication. Atropine may precipitate angle closure in patients. In elderly men with prostatic hyperplasia, antimuscarinic drugs should be avoided. Nonselective antimuscarinic agents should never be used to acid-peptic disease. Because they slow ...
... Glaucoma, especially angle-closure glaucoma, is a contraindication. Atropine may precipitate angle closure in patients. In elderly men with prostatic hyperplasia, antimuscarinic drugs should be avoided. Nonselective antimuscarinic agents should never be used to acid-peptic disease. Because they slow ...
Histamine and Antihistaminic Agents
... second generation antihistamines and is essential for significant H1-receptor affinity. Furthermore several SAR studies suggest that the two aryl moieties must be capable of adopting a noncoplanar conformation relative to each other for optimal interaction with the H1-receptor. The two aromatic syst ...
... second generation antihistamines and is essential for significant H1-receptor affinity. Furthermore several SAR studies suggest that the two aryl moieties must be capable of adopting a noncoplanar conformation relative to each other for optimal interaction with the H1-receptor. The two aromatic syst ...
Strategies for Repeat Prostate Biopsies
... as the most accurate predictor of a positive repeat biopsy result in patients with PSA levels between 4 and 10 ng/ml [2]. Busby and Evans recommend a combination of total PSA, percent free PSA, PSAD, and PSAV based on analysis of the published data on each of these parameters [3]. Their recommended ...
... as the most accurate predictor of a positive repeat biopsy result in patients with PSA levels between 4 and 10 ng/ml [2]. Busby and Evans recommend a combination of total PSA, percent free PSA, PSAD, and PSAV based on analysis of the published data on each of these parameters [3]. Their recommended ...
Pharm Chapter 10 [4-20
... Not used often cause they aren’t specific and inhibit all catecholamines α methyltyrosine- structural analogue of tyrosine that is taken into nerve terminals, where it inhibits tyrosine hydroxylase, the first enzyme in the making of catecholamines o Used sometimes to treat hypertension from a pheoch ...
... Not used often cause they aren’t specific and inhibit all catecholamines α methyltyrosine- structural analogue of tyrosine that is taken into nerve terminals, where it inhibits tyrosine hydroxylase, the first enzyme in the making of catecholamines o Used sometimes to treat hypertension from a pheoch ...
PASS assisted search and evaluation of some azetidin-2
... 1]. Substitution of quinazolinones at 3-position with 2azetidinone has resulted in compounds of structure 1, where compounds 1 a, b and c were potent against oxotremorine-induced tremors. The active compounds have phenyl, 2-chlorophenyl and 3-furyl group respectively at the C4 position of the azetid ...
... 1]. Substitution of quinazolinones at 3-position with 2azetidinone has resulted in compounds of structure 1, where compounds 1 a, b and c were potent against oxotremorine-induced tremors. The active compounds have phenyl, 2-chlorophenyl and 3-furyl group respectively at the C4 position of the azetid ...
18 Male reproductive system Prostate and seminal vesicles Testis
... enter the urethra, which are also referred to as the periurethral and transitional zones. This fact supports the interpretation that this portion of the gland reacts differently to hormonal stimuli than the outer portion. In most instances the nodules congregate on both sides of the urethra, resulti ...
... enter the urethra, which are also referred to as the periurethral and transitional zones. This fact supports the interpretation that this portion of the gland reacts differently to hormonal stimuli than the outer portion. In most instances the nodules congregate on both sides of the urethra, resulti ...
... T.B(94.16%). When compared to the CCl4 toxic control group, the group treated with the methanol extracts of Glycosmis pentaphylla, at doses of 100, 200 and 400mg/kg; p.o in CCl4 intoxicated rats exhibited a significant reduction (p<0.01) of SGOT(32.14%, 49.99%, 65.33%), SGPT(27.98%, 39.90%, 50.81%), ...
Gen. Pharmac. Vol. 27, No. ... ISSN 0306-3623/96 15.00 + .00 0306-3623(95)02019-A
... (Kochakian, 1993) was confirmed by the influence of the treatment on body weight gain in young mice. However, it is interesting to note that a similar result was not found in adult mice. Lombardo (1993), in a review of the effects of several AAS on physical parameters, has reported that intact male ...
... (Kochakian, 1993) was confirmed by the influence of the treatment on body weight gain in young mice. However, it is interesting to note that a similar result was not found in adult mice. Lombardo (1993), in a review of the effects of several AAS on physical parameters, has reported that intact male ...
Long-Term Effects of Olanzapine, Risperidone, and Quetiapine on
... their ability to induce some extrapyramidal effects. Inability of quetiapine to alter DA receptors suggests that nondopaminergic mechanisms contribute to its antipsychotic effects. ...
... their ability to induce some extrapyramidal effects. Inability of quetiapine to alter DA receptors suggests that nondopaminergic mechanisms contribute to its antipsychotic effects. ...
What Is the Role of Neurotransmitter Systems in Cortical Seizures?
... agonist had to be modified according to the age to have subconvulsant doses of similar potency in all three age groups. None of the tested agonists affected movements directly elicited by stimulation. N-methyl-D-aspartate (NMDA) as a prototypic agonist of one class of ionotropic glutamate receptors ...
... agonist had to be modified according to the age to have subconvulsant doses of similar potency in all three age groups. None of the tested agonists affected movements directly elicited by stimulation. N-methyl-D-aspartate (NMDA) as a prototypic agonist of one class of ionotropic glutamate receptors ...
Chapter 8 Cholinoceptor
... Glaucoma, especially angle-closure glaucoma, is a contraindication. Atropine may precipitate angle closure in patients. In elderly men with prostatic hyperplasia, antimuscarinic drugs should be avoided. Nonselective antimuscarinic agents should never be used to acid-peptic disease. Because they slow ...
... Glaucoma, especially angle-closure glaucoma, is a contraindication. Atropine may precipitate angle closure in patients. In elderly men with prostatic hyperplasia, antimuscarinic drugs should be avoided. Nonselective antimuscarinic agents should never be used to acid-peptic disease. Because they slow ...
Characterization of the Analgesic and Anti
... The purified COX enzymes were reconstituted with 2 mM phenol and 1 mM hematin and the cyclooxygenase activity was measured using a radiometric assay (Barnett et al., 1994). Putative inhibitors (2–15 ml) were diluted in DMSO and preincubated with the appropriate recombinant COX (3–15 ng) at a final c ...
... The purified COX enzymes were reconstituted with 2 mM phenol and 1 mM hematin and the cyclooxygenase activity was measured using a radiometric assay (Barnett et al., 1994). Putative inhibitors (2–15 ml) were diluted in DMSO and preincubated with the appropriate recombinant COX (3–15 ng) at a final c ...
Endocrine disrupting substances
... Chemical substances may disturb these functions by affecting hormonal signalling. In order to understand how hormonal systems are disturbed it is essential to have knowledge of their natural functions. The report has focused on three hormonal systems, the sex hormones (estrogens, androgens and proge ...
... Chemical substances may disturb these functions by affecting hormonal signalling. In order to understand how hormonal systems are disturbed it is essential to have knowledge of their natural functions. The report has focused on three hormonal systems, the sex hormones (estrogens, androgens and proge ...
CARDIOVASCULAR ENDOCRINOLOGY Endogenous Sex
... men with lower androgenicity seem to be at greater risk for CVD (47, 48). Furthermore, T supplementation may increase blood fibrinolytic activity and produce clinical improvement in patients with occlusive vascular disease (49, 50). Other risk factors. An elevated plasma level of homocysteine (tHcy) ...
... men with lower androgenicity seem to be at greater risk for CVD (47, 48). Furthermore, T supplementation may increase blood fibrinolytic activity and produce clinical improvement in patients with occlusive vascular disease (49, 50). Other risk factors. An elevated plasma level of homocysteine (tHcy) ...
Effects of Enoyl-Acyl Protein Carrier Reductase Mutations on
... and action site of INH is inhA gene product, namely enoyl-acyl carrier protein reductase (InhA), is catalyzing the synthesis of the fatty acids [13-19]. Different mechanisms of INH activation have been reviewed by Scior et al. [20]. More studies have also demonstrated that the mutations within katG ...
... and action site of INH is inhA gene product, namely enoyl-acyl carrier protein reductase (InhA), is catalyzing the synthesis of the fatty acids [13-19]. Different mechanisms of INH activation have been reviewed by Scior et al. [20]. More studies have also demonstrated that the mutations within katG ...
May 2011 - Prostatitis Foundation
... strictures do not have prostatitis. The typical symptoms of a urethral stricture are a slow urine flow rate, straining to urinate, and prolonged urination. However, other patients also have pain with urination and develop recurrent infections, including infections of the prostate. Urethral Stricture ...
... strictures do not have prostatitis. The typical symptoms of a urethral stricture are a slow urine flow rate, straining to urinate, and prolonged urination. However, other patients also have pain with urination and develop recurrent infections, including infections of the prostate. Urethral Stricture ...
Thyroid Gland
... • Fundamental differences in thyroid hormone economy in rats – Rapid half-life of T4 – Lack of thyroid binding globulin – High TSH concentrations (greater in males) – Low secretion rate of T4 (inherently less able to make T4 compared to humans) – Sensitive to the tumorigenic effects of drugs that de ...
... • Fundamental differences in thyroid hormone economy in rats – Rapid half-life of T4 – Lack of thyroid binding globulin – High TSH concentrations (greater in males) – Low secretion rate of T4 (inherently less able to make T4 compared to humans) – Sensitive to the tumorigenic effects of drugs that de ...
iPPI small molecule inhibitor of Protein
... orally available are known at this time) or can be allosteric inhibitors, thereby binding at, near or far away from the interface in cavities with recognition characteristics that could be highly similar to enzyme active sites. It would seem logical to explore and attempt to rationalize the propert ...
... orally available are known at this time) or can be allosteric inhibitors, thereby binding at, near or far away from the interface in cavities with recognition characteristics that could be highly similar to enzyme active sites. It would seem logical to explore and attempt to rationalize the propert ...
6 Synergy and polyvalence: paradigms to explain the activity of herbal products
... adjuvant herbs are clearly recognised and classified. Thus, in a Chinese prescription of, say, ten different herbs, one is recognised as providing the major activity, i.e. ‘the monarch’, while two or three others have a similar activity, i.e. ‘the ministers’, one or more others are included to aid a ...
... adjuvant herbs are clearly recognised and classified. Thus, in a Chinese prescription of, say, ten different herbs, one is recognised as providing the major activity, i.e. ‘the monarch’, while two or three others have a similar activity, i.e. ‘the ministers’, one or more others are included to aid a ...
EXPLORING THE EFFECTS OF NEWER THREE COMPONENT AMINOBENZYLATED REACTIONS OF TRIPHENYL IMIDAZOLE MOTIF AS POTENT ANTIMICROBIAL AND ANTIINFLAMMATORY
... reactivity and manifold biological activities. This structural template shows remarkable pharmacological activities such as antibacterial1,2, anti‐inflammatory3,4, anticonvulsive5, anthelmintic6, antiulcer7, antiviral8, antitumour9, antispasmodic10, antioxidant11 and antitubercular12. In ...
... reactivity and manifold biological activities. This structural template shows remarkable pharmacological activities such as antibacterial1,2, anti‐inflammatory3,4, anticonvulsive5, anthelmintic6, antiulcer7, antiviral8, antitumour9, antispasmodic10, antioxidant11 and antitubercular12. In ...
The Role of Ligand Efficiency Measures in Drug Discovery
... due to less favorable binding entropies for larger, more flexible ligands.40 However, in an analysis of the number of energetically accessible conformations for several thousand ligands of varying sizes and affinities no trend could be found for increased conformational entropies as ligand size incr ...
... due to less favorable binding entropies for larger, more flexible ligands.40 However, in an analysis of the number of energetically accessible conformations for several thousand ligands of varying sizes and affinities no trend could be found for increased conformational entropies as ligand size incr ...
the effects of zolmitriptan on nasal mucociliary clearance (nmcc)
... Measuring the speed at which particles are moved by cilia gives us objective information about one of the most important physiological actions of the respiratory tract .Because many drugs enhance but other reduce the mucociliary clearance so we can evaluate various drugs as to this action2.The sacch ...
... Measuring the speed at which particles are moved by cilia gives us objective information about one of the most important physiological actions of the respiratory tract .Because many drugs enhance but other reduce the mucociliary clearance so we can evaluate various drugs as to this action2.The sacch ...
Prostate Cancer and Its Influence on Men´s Daily Lives
... to nearly 9000 new cases each year and makes prostate cancer the most common cancer among males in Sweden. This is also true for many western countries, such as in Northern Europe and in the US. On average, the incidence of prostate cancer in Sweden has increased by 2.8 per cent per annum seen over ...
... to nearly 9000 new cases each year and makes prostate cancer the most common cancer among males in Sweden. This is also true for many western countries, such as in Northern Europe and in the US. On average, the incidence of prostate cancer in Sweden has increased by 2.8 per cent per annum seen over ...
CP47,497-C8 and JWH073, commonly found in `Spice` herbal
... amounts of internalization produced by these drugs at 10 nM (P b 0.018), 100 nM (P b 0.0001), and at 1 μM (P b 0.0092). Fig. 4C shows that in all cases 1 μM rimonabant prevented internalization due to treatment with 1 μM of each of these drugs, demonstrating that internalization by these drugs is du ...
... amounts of internalization produced by these drugs at 10 nM (P b 0.018), 100 nM (P b 0.0001), and at 1 μM (P b 0.0092). Fig. 4C shows that in all cases 1 μM rimonabant prevented internalization due to treatment with 1 μM of each of these drugs, demonstrating that internalization by these drugs is du ...
Discovery and development of antiandrogens
In the 1960s, the first antiandrogen, or androgen antagonist, was discovered. Antiandrogens antagonise the androgen receptor (AR) and thereby block the biological effects of testosterone and dihydrotestosterone (DHT). Antiandrogens are important for men with hormonally responsive diseases like prostate cancer, benign prostatic hyperplasia (BHP), acne, seborrhea, hirsutism and androgen alopecia. Antiandrogens are mainly used for the treatment of prostate diseases. Research from 2010 suggests that ARs could be linked to the disease progression of triple-negative breast cancer and that antiandrogens can potentially be used to treat it.As of 2010 antiandrogens are small molecules and can be either steroidal or nonsteroidal depending on ligand chemistry. Steroidal antiandrogens share a similar steroid structure, while nonsteroidal antiandrogens may have structurally distinctive pharmacophores. Only a limited number of compounds are available for clinical use despite the fact that a very large variety of antiandrogen compounds have been discovered and researched.