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Schlom
Schlom

... J. Schlom is an inventor on patents via NCI TTC and NIH OTT. Drs. Schlom and Madan will discuss experimental therapeutic cancer vaccines in different states of clinical development: PROSTVAC and PANVAC. ...
Management of Early-Stage Prostate Cancer
Management of Early-Stage Prostate Cancer

... prostatectomy.11 Patients whose PSA levels increase by more than 2.0 ng/mL per year before undergoing surgery or radiation therapy may have a higher rate of prostate cancer recurrence.12 The proPSA is a molecular form of free PSA (fPSA) that is more likely to be associated with prostate cancer. The ...
Diseased
Diseased

... 2) When treatment before symptoms is better than treatment after symptoms appear. (e.g. cervical cancer.)  Need a detectable pre-clinical phase (DPCP)  Presumes existence of an effective test 3) High prevalence of undiagnosed disease in the DPCP. (Prevalence of HIV in couples applying for a marria ...
Increased Risk of Metabolic Syndrome, Diabetes Mellitus, and
Increased Risk of Metabolic Syndrome, Diabetes Mellitus, and

... Surgery. A prostatectomy (surgical removal of the prostate) is a common treatment method in men whose cancer has not spread beyond the prostate, but may also be performed on later stages, as well. Radiation Therapy. Radiation therapy uses certain types high energy beams of radiation to shrink tumors ...
SERUM SEX STEROIDS DEPICT A NONLINEAR U
SERUM SEX STEROIDS DEPICT A NONLINEAR U

... reports the characteristics and descriptive statistics examined according to NCCN guidelines riskclass segregation. Patients in the high-risk class showed the lowest serum tT and E2 levels as well as the lowest mean tT–E2 ratio (all p  0.02). In contrast, patients did not differ in terms of age, BM ...
Androgen-Induced Differentiation and Tumorigenicity of Human
Androgen-Induced Differentiation and Tumorigenicity of Human

... To study the molecular alterations associated with prostate cancer, several groups have developed human and murine experimental systems (5, 6). However, prostate cancer cell lines have proven difficult to isolate and often fail to recapitulate early stage disease (7). As a result, much of our knowle ...
Head and Neck Cancer
Head and Neck Cancer

Time from diagnosis to surgery and prostate cancer survival: a
Time from diagnosis to surgery and prostate cancer survival: a

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L A

Integrating the RKin into Oncologic Care
Integrating the RKin into Oncologic Care

... Does PA reduce cancer recurrence and/or improve survival? Does PA influence cancer treatment decisions, completion rates, and/or response? What is the optimal PA prescription for cancer survivors? What is the role of sedentary behaviour in cancer survivorship? What are the most effective PA behaviou ...
standard treatment guidelines urology
standard treatment guidelines urology

... classified according to entities with predominating clinical symptoms: (I) uncomplicated lower UTI (cystitis); (2) uncomplicated pyelonephritis; (3) complicated UTI with or without pyelonephritis; (4) Urosepsis; (5) urethritis; and (6) prostatitis, epididymitis, orchitis. ...
THE HON TANYA PLIBERSEK MP Minister for
THE HON TANYA PLIBERSEK MP Minister for

... psychosocial needs unique to these patients. This will provide concrete direction for new and effective treatments, clinical management and supportive care programs. Professor Melissa Southey (University of Melbourne) and co-funded by Cancer Australia and National Breast Cancer Foundation High Risk ...
Handout (in pdf format) with speaker notes
Handout (in pdf format) with speaker notes

... information on the findings from the physical as reported by the physician including an overall report of the patient’s general health status and whether or not a tumor is clinically apparent through a digital rectal exam (DRE). The DRE documentation may provide information on extracapsular extensio ...
Overview of brachytherapy for localised prostate cancer
Overview of brachytherapy for localised prostate cancer

... Prostate cancer is one of the most common cancers in men. It tends to affect older men, with the risk rising with age. It is not a single disease entity but may be indicated form an incidental biopsy finding to presentation with metastatic prostate cancer, which may or may not cause any symptoms or ...
Maori Surviving Prostate Cancer
Maori Surviving Prostate Cancer

... standardisation is needed first ...
Reverse Atherosclerosis
Reverse Atherosclerosis

... group worsened by 17% after three months, whereas coronary blood flow improved by 18% in the pomegranate group. This study showed for the first time that daily consumption of pomegranate can improve blood flow to the heart in coronary artery disease patients in a relatively short period of time. The ...
The role of surgery in high‐risk localised prostate cancer
The role of surgery in high‐risk localised prostate cancer

... reduced positive margin rates. There was, before RP. Although all men achieved however, no difference seen in PSA undetectable PSA levels after surgery, the progression rates after surgery. In all these study endpoint of achieving a 20% pT0 rate studies a consistent finding was that ADT was not achi ...
Predictors of Biochemical Failure Following Radical
Predictors of Biochemical Failure Following Radical

Gene symbol Gene name Reason for inclusion in this study
Gene symbol Gene name Reason for inclusion in this study

... dismutase family. Polymorphisms in this gene have been associated with premature aging, and certain cancers. The SNP was identified as a risk factor for prostate cancer by a genome-wide association study. The SNP was identified as a risk factor for prostate cancer by a genome-wide association study. ...
Temporal trends and racial disparities in global prostate cancer
Temporal trends and racial disparities in global prostate cancer

... as the total number of individuals accrued over a time period. This period differed from study to study. Assuming a population is stable and the incidence and prevalence rates are unchanging, the relationship of incidence and prevalence rates are well known as It=Pp/D(1–Pp),where It is the person-ti ...
Clinical Conundrums in Cancer Chemoprevention: What Should
Clinical Conundrums in Cancer Chemoprevention: What Should

... Rothwell PM et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomized controlled trials. Lancet 2012;379:1602. Spencer FA and Guyatt G. Aspirin in the primary prevention of cardiovascular dise ...
Evaluation of Investigator’s Progress
Evaluation of Investigator’s Progress

Original Article anti Characterization of primary prostate carcinoma by F] -fluorocyclobutane-1-carboxylic
Original Article anti Characterization of primary prostate carcinoma by F] -fluorocyclobutane-1-carboxylic

Press Release - IARC: 2016 International Childhood Cancer
Press Release - IARC: 2016 International Childhood Cancer

... Much remains to be done to fight childhood cancer Lyon, France, 15 February 2016 – New estimates by the International Agency for Research on Cancer (IARC) show that the global occurrence of childhood1 cancer is higher than previously assessed. Worldwide, approximately 215 000 cancers are diagnosed p ...
Bone Metastases and Bone Loss Medical Treatment in Prostate
Bone Metastases and Bone Loss Medical Treatment in Prostate

< 1 ... 46 47 48 49 50 51 52 53 54 ... 133 >

Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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