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Potential Surrogate Endpoints for Prostate
Potential Surrogate Endpoints for Prostate

... probably not failed. A landmark analysis (9) was used to correct for this length bias. Only patients alive at the landmark time, 3 or 5 years, were included in the analysis and their surrogate endpoint failure status was assessed at the landmark time. The true endpoint was time to events for prostat ...
MEDIA ADVISORY - National Cancer Registrars Association
MEDIA ADVISORY - National Cancer Registrars Association

... sound footing from which cancer care and treatment can advance.” This year’s theme — Cancer Registrars: The Lighthouse in a Storm of Change — was chosen to acknowledge how cancer registrars have stayed the course through a myriad of changes. The way cancer is diagnosed and the treatment protocols ar ...
Risk Factors and Screening Guidelines for the 12 Most
Risk Factors and Screening Guidelines for the 12 Most

... The specialists in the Saint Louis University Cancer Center at Saint Louis University Hospital are known for advancing the diagnosis and treatment of cancer. They’re also seeking early cancer detection methods as well as ways to reduce the risk of getting cancer. The Quick Reference is a part of thi ...
Bisphenol A facilitates bypass of androgen ablation therapy in
Bisphenol A facilitates bypass of androgen ablation therapy in

Document
Document

Localised prostate cancer - Prostate Cancer Foundation of New
Localised prostate cancer - Prostate Cancer Foundation of New

... Specialist Nurses on our confidential helpline. Active surveillance Prostate cancer may be slow growing and, for many men, may never progress or cause any symptoms. Active surveillance is a way of monitoring prostate cancer. It aims to avoid or delay unnecessary treatment in men with low risk locali ...
Your Gifts at Work
Your Gifts at Work

... cancer patients with valuable information about their diagnosis and assists them of their cancer journey. Wigs, turbans, and head coverings are available in a variety of styles, colors, and sizes. Transportation Assistance - trained volunteers drive cancer patients to and from their treatments. In a ...
controllable diseases
controllable diseases

... people and that there will be no major breakthrough in this area in early detection. It  means  in  prostate  cancer  that  PSA  and  ultrasound  approaches  will  continue  with  high  false alarm rates and excess procedure and that also genetic markers will be used in a  limited  manner.  There  d ...
18F-Choline PET/MRI: The Additional Value of PET for MRI
18F-Choline PET/MRI: The Additional Value of PET for MRI

... PET and MRI data with the added benefit of functional imaging. It has been shown that increased choline uptake is associated with significant primary prostate cancer (3) and cancers with elevated tumor cell proliferation markers (MIB-1/Ki-67) (4). Although choline uptake is not specific for prostate ...
lwwus_coc_ajco-14-16 278..288 - Description
lwwus_coc_ajco-14-16 278..288 - Description

... Toxicity was similar in the 2 arms. Of note, by modern standards, the dose in the EBRT alone arm is lower than the current standard, and it is unknown whether brachytherapy plus EBRT would be superior to EBRT using present-day EBRT doses. Data to help address this issue are presented in a paper that ...
Genetic and Molecular Differences in Prostate Carcinogenesis
Genetic and Molecular Differences in Prostate Carcinogenesis

... poor CaP outcomes, which is more prevalent among AA men than Caucasian American (CA) men [4]. While ethnic differences in CaP incidence have been noted across the world, this review focuses on differences between AA and CA men. There are populations in which AA men have similar outcomes to CA men. S ...
World Cancer Day
World Cancer Day

... World Cancer Day celebration was planned in Geneva, Switzerland in 1933 under the direction of UICC (Union for International Cancer Control) and with the support of various other well-known cancer societies, research institutes, treatment centers and patient groups. The World Cancer Day event was fo ...
the munich declaration
the munich declaration

... framework for the early detection of colorectal cancer which had been established 30 years ago neither a reduction in the numbers of newly diagnosed cases nor in the in the fatalities were achieved. Yet, when a public healthcare reform took place in 2000, the legal framework for the early detection ...
View PDF - CiteSeerX
View PDF - CiteSeerX

... Received May 27, 2002; accepted August 30, 2002. ...
Milk Consumption and Prostate Cancer
Milk Consumption and Prostate Cancer

... increased risk of prostate cancer, compared to having less than one-half serving daily, after adjustment for age, smoking, exercise level, and body mass index (BMI).25 Among the studies finding no association between dairy product use and prostate cancer, one, conducted in Norway, found a significan ...
cancer in the region of the americas
cancer in the region of the americas

... There are safe and effective vaccines against the human papilloma virus (HPV), which causes cervical cancer and against the hepatitis B virus (HBV), which causes liver cancer. Cervical cancer caused over 35,600 deaths in Latin America and the Caribbean in 2012, representing the second most common ca ...
dentification of en with a genetic predisposition to rost
dentification of en with a genetic predisposition to rost

MSR1 variants and the risks of prostate cancer
MSR1 variants and the risks of prostate cancer

... highly penetrant genes and more common polymorphisms with mild effects on androgen biosynthesis/metabolism, DNA repair and chronic inflammation pathways (3,4). Emerging epidemiologic evidence suggests that chronic inflammation in the prostate increases the risk of prostate cancer (5–7). For example, ...
IMPACT protocol - V18 03/10/2012
IMPACT protocol - V18 03/10/2012

... Version 18 03/10/2012 Professor David Dearnaley MA; MD; FRCR; FRCP Head of Urology Unit ...
For more information on accessing electronic
For more information on accessing electronic

... value (PPV) of 68%, and negative predictive value (NPV) of 100%. On a per-lobe basis, MRI had a sensitivity of 65%, specificity of 84%, PPV of 60%, and NPV of 86%. There was a nearly significant association between Gleason score and tumor detection on MRI (P = 0.072). Conclusions In our sample, MRI ...
Ejaculation Frequency and Risk of Prostate Cancer: Updated
Ejaculation Frequency and Risk of Prostate Cancer: Updated

... If men with erectile dysfunction have lower ejaculatory frequency and serious comorbidities associated with a higher risk of premature death from other causes, a spurious association between less frequent ejaculation and reduced risk of PCa could result. To address this issue, we performed a sensiti ...
pdf
pdf

... __________________ Accepted after revision: November 30, 2012 ...
Everything you never wanted to know about cancer data, but need
Everything you never wanted to know about cancer data, but need

... to provide information on cancer statistics in an effort to reduce the burden of cancer among the U.S. population SEER collects data on cancer cases from various locations and sources throughout the United States. Data collection began in 1973 with a limited amount of registries and continues to exp ...
The number of lymph nodes in the lymphadenectomy specimen was
The number of lymph nodes in the lymphadenectomy specimen was

... function of patients (pts) submitted to RRP for localized prostate cancer. Materials and Methods One hundred and twenty consecutive pts with localised prostate cancer and submitted to RRP were included and randomly divided into 3 groups (Group 1, Group 2 and Group 3). RRP was performed by a high-vol ...
Management of Early-Stage Prostate Cancer
Management of Early-Stage Prostate Cancer

... prostatectomy.11 Patients whose PSA levels increase by more than 2.0 ng/mL per year before undergoing surgery or radiation therapy may have a higher rate of prostate cancer recurrence.12 The proPSA is a molecular form of free PSA (fPSA) that is more likely to be associated with prostate cancer. The ...
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Prostate-specific antigen

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. PSA is produced for the ejaculate, where it liquefies semen in the seminal coagulum and allows sperm to swim freely. It is also believed to be instrumental in dissolving cervical mucus, allowing the entry of sperm into the uterus.PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. The United States Preventive Services Task Force (USPSTF, 2012) does not recommend PSA screening, noting that the test may result in “overdiagnosis” and “overtreatment” because ""most prostate cancer is asymptomatic for life"" and treatments involve risks of complications including impotence (erectile dysfunction) and incontinence. The USPSTF concludes ""the potential benefit does not outweigh the expected harms."" PSA is not a unique indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. 30 percent of patients with high PSA have prostate cancer diagnosed after biopsy.
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