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THE MULTIFARIOUS AND DYNAMIC REGULATION OF THE LIVING CELL Karen van Eunen
THE MULTIFARIOUS AND DYNAMIC REGULATION OF THE LIVING CELL Karen van Eunen

... technologies together with the increase in computer capacity for data storage and analysis have led to a new approach in the life sciences. This genomics or ‘omics’ approach refers to a broad discipline in which the biological information is analyzed genome-wide at all accessible levels of regulatio ...
Branched-chain amino acid restriction in Zucker
Branched-chain amino acid restriction in Zucker

... were anesthetized with 2% isoflurane (Butler Schein, Dublin OH), and polyethylene catheters were aseptically placed in the left carotid artery (advanced to the aortic arch) or the right jugular vein. Catheters were filled with 3% heparinized saline to maintain patency and exteriorized in the intrascap ...
Ethylene is involved in strawberry fruit ripening in an organ
Ethylene is involved in strawberry fruit ripening in an organ

... three ethylene receptor genes, two type I (FaEtr1 and FaErs1) and one type II (FaEtr2), have been identified. Moreover, their expression during ripening as well as their response to different hormone treatments have been studied (Trainotti et  al., 2005). In general, a good correlation exists betwee ...
MESOTHERAPY - ozone
MESOTHERAPY - ozone

... mesoderm with very good effect on treating dermatological lesions (ectoderm) or even internal lesions as GIT (endermic).  This term is suggested by Dr.Michel Pistor (French doctor 1958).  Meso.= Middle; since we are aiming at correct location. OR = mean : Intermediary dosage between Allopathic the ...
Development, validation and biological application of
Development, validation and biological application of

... Altered lipid metabolism is a hallmark of multiple diseases such as diabetes and cancer, so there is a vast interest in the accurate determination of lipid synthesis fluxes. However, there is no gold standard for measuring these fluxes. Therefore, the initial goal of this project was to develop and ...
Presentation 2013-201307040352
Presentation 2013-201307040352

... Require altered optimal drug dosage for patient ...
Design, Synthesis, and Antibacterial Properties of Dual
Design, Synthesis, and Antibacterial Properties of Dual

... Bactericidal Agent Time ...
Life in the slow lane: molecular mechanisms of estivation
Life in the slow lane: molecular mechanisms of estivation

... estivate in sheltered sites, often underground. In general, estivation includes a strong reduction in metabolic rate, a primary reliance on lipid oxidation to fuel metabolism, and methods of water retention, both physical (e.g. cocoons) and metabolic (e.g. urea accumulation). The present review focu ...
Inhibitory Effects of Neurotransmitters and Steroids on Human
Inhibitory Effects of Neurotransmitters and Steroids on Human

... inhibition of P450 are useful to predict drug efficacy, drug interaction, and drug toxicity. Because many endogenous compounds are substrates of P450s, they may inhibit drug metabolism catalyzed by P450s. Previous studies reported that human CYP1A2 (Agúndez et al., 1998), CYP2C9 (Gervasini et al., ...
Biosynthesis of Glucosyl Glycerol, a Compatible Solute, Using
Biosynthesis of Glucosyl Glycerol, a Compatible Solute, Using

... the intermolecular transglycosylation activity of ASase has gained increasing attention because it uses a relatively cheap substrate, sucrose, as well as its broad range of acceptor specificity [7, 8]. ASase can employ not only various glycones such as salicin [9] and arbutin [10] but also numerous ...
L-carnitine
L-carnitine

... modestly improve exercise tolerance and decrease electrocardiographic signs of ischemia during exercise testing in a limited number of angina patients. One randomized, placebocontrolled study in 200 patients with exercise-induced stable angina found that supplementing conventional medical therapy w ...
PDF
PDF

... composed of non-neutral lipid or synthesized during the earlier cleavage stages prior to incubation in radioactive medium (Fig. Ad). Silver grains were also found ...
Mechanistic insights into the regulation of metabolic enzymes by
Mechanistic insights into the regulation of metabolic enzymes by

... acetylation is emerging as a major regulatory mechanism in metabolism that is involved in all three levels of controlling metabolic enzymes and is altered frequently in human diseases. Acetylation rivals other common posttranslational modifications in cell regulation not only in the number of substr ...
Ketone body metabolism and cardiovascular disease - AJP
Ketone body metabolism and cardiovascular disease - AJP

... Thiolase, any enzyme that catalyzes the reversible condensation of acetyl-CoA to acetoacetyl-CoA. This enzymatic activity is redundant in mammals. Ketone Body Metabolism The fundamental biochemical and physiological roles of ketone body metabolism have been extensively studied and reviewed (68, 137, ...
Metabolic liver disease in children
Metabolic liver disease in children

... before the deterioration of lung function.24 The best outcomes are seen in patients without severe lung involvement, and pulmonary status may improve post– liver transplant.24,34-36 Optimal timing for transplantation should be influenced by several factors, such as pulmonary status, nutritional statu ...
Prezentace aplikace PowerPoint
Prezentace aplikace PowerPoint

... Decrease of extracellular space volume ...
2014 Annual Report - Lupus Foundation of Southern Arizona
2014 Annual Report - Lupus Foundation of Southern Arizona

... because the presenting symptoms and signs are often not specific; and over-diagnosis because doctors mistakenly use a positive blood test (present in 5% of the healthy population) by itself, to make a diagnosis. Treatment consists primarily of immunosuppressive drugs such as hydroxychloroquine (Plaq ...
Untangling the relationship between diet and visceral fat mass
Untangling the relationship between diet and visceral fat mass

... (n = 1109), a linear regression was performed for each of the 20 food groups (predictor variable) adjusted for covariates (total fat mass, age, sex, height2, family relatedness, dual-energy x-ray absorptiometry batch) with VFM (residual adjusted for BMI) as the response variable. Associations were c ...
Platelet Dysfunction in Glycogen Storage Disease
Platelet Dysfunction in Glycogen Storage Disease

... active ...
GenScript TissueDirect Multiplex PCR System Protocol
GenScript TissueDirect Multiplex PCR System Protocol

... 2. Seal plate with cover and incubate at 37°C for 90 minutes. 3. Remove cover and discard the solution in each well. Strike plate on fresh towels to make wells clean, but do not allow them to dry completely at any time. 4. Add 0.1 ml of biotinylated anti-mouse laminin antibody working solution into ...
Effects upon metabolic pathways and energy production by Sb(III
Effects upon metabolic pathways and energy production by Sb(III

... more Sb(III) would enter bacterial cells, however, the cytoplasmic AnoA and the oxidative stress response proteins were significantly up-regulated, which may contribute to the increased Sb(III) oxidation efficiency. Moreover, the carbon metabolism was also activated to generate more energy against S ...
Slowed glycogen utilization enhances exercise endurance
Slowed glycogen utilization enhances exercise endurance

... breath of CHF patients were increased in the glycogendepleted state. This is consistent with increased peroxidation of free fatty acids (1). In normal subjects, glycogen depletion did not affect maximal VO2 but significantly diminished exercise endurance. Subjectively, with glycogen depletion, norma ...
Berleman, J. Analysis of inter-species interactions and
Berleman, J. Analysis of inter-species interactions and

... Firmicutes, and the furanosyl borate diester (commonly called autoinducer 2, or AI-2) which is dependent on activity of the LuxS protein and present in many domains of bacteria. However, analysis of 818 currently available complete bacterial genomes indicates that only 322 (39%) of these genomes con ...
Direction of Krebs cycle Which way does the citric acid cycle turn
Direction of Krebs cycle Which way does the citric acid cycle turn

... transhydrogenase, while mice belonging to any of the following strains: C57BL/6JEi, C57BL/6N, C57BL/6NJ, C57BL/6ByJ, C57BL/10J, C57L/J, or C58/J express this protein (Toye et al., 2005). To the best of my knowledge, the results of such an experiment do not exist in the literature. Apart from regener ...
Full-Text PDF
Full-Text PDF

... through light reactions. Subsequently, they are used to convert CO2 into central metabolites, which can be used for biochemical synthesis. Most commonly used cyanobacterial models (Table 1) are Synechococcus elongatus PCC 7942, Synechocystis PCC 6803, Synechococcus sp. PCC 7002, and Anabaena sp. PCC ...
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Pharmacometabolomics

Pharmacometabolomics, also known as pharmacometabonomics, is a field which stems from metabolomics, the quantification and analysis of metabolites produced by the body. It refers to the direct measurement of metabolites in an individual’s bodily fluids, in order to predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Alternatively, pharmacometabolomics can be applied to measure metabolite levels following the administration of a pharmaceutical compound, in order to monitor the effects of the compound on certain metabolic pathways(pharmacodynamics). This provides detailed mapping of drug effects on metabolism and the pathways that are implicated in mechanism of variation of response to treatment. In addition, the metabolic profile of an individual at baseline (metabotype) provides information about how individuals respond to treatment and highlights heterogeneity within a disease state. All three approaches require the quantification of metabolites found in bodily fluids and tissue, such as blood or urine, and can be used in the assessment of pharmaceutical treatment options for numerous disease states.
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