The Intermediary Metabolism of Cholesterol
... steroids require for their synthesis intact cellular systems a study of cholesterol synthesis in simple systems of known compositions is not feasible at the present time. Synthesis of cholesterol can be demonstrated under in vitro conditions as well as in the intact animal.'4 The reaction takes plac ...
... steroids require for their synthesis intact cellular systems a study of cholesterol synthesis in simple systems of known compositions is not feasible at the present time. Synthesis of cholesterol can be demonstrated under in vitro conditions as well as in the intact animal.'4 The reaction takes plac ...
Elucidating Flux Regulation of the Fermentation Modes of
... without any previous experience in biological experiments, to survive in the lab. He always came up with pragmatic solutions as well as interesting ideas that led to new directions. The most important thing of all that I have learnt from him, for a skeptical person like me, is his will power and fai ...
... without any previous experience in biological experiments, to survive in the lab. He always came up with pragmatic solutions as well as interesting ideas that led to new directions. The most important thing of all that I have learnt from him, for a skeptical person like me, is his will power and fai ...
Text S1: General Metabolism
... In summary, both X. nematophila and X. bovienii have metabolic profiles as expected for bacteria capable of being free living, host-associated, and pathogenic by turns. However, there are several unique pathways to each species, including cellobiose transport and presence of a putative virulence-lin ...
... In summary, both X. nematophila and X. bovienii have metabolic profiles as expected for bacteria capable of being free living, host-associated, and pathogenic by turns. However, there are several unique pathways to each species, including cellobiose transport and presence of a putative virulence-lin ...
Selective 15N labeling and direct observation by NMR
... Freeman, 1979) spectra, the fact that the intensity between 116 and 130 ppm is maximized by a total refocusing delay of 1/2J, positive but smaller after delays of 1/4J or 3/4J and negative after a delay of 5/4J, identifies it as due to NH groups and thus backbone amides (Fig. 3, Table 2). By contras ...
... Freeman, 1979) spectra, the fact that the intensity between 116 and 130 ppm is maximized by a total refocusing delay of 1/2J, positive but smaller after delays of 1/4J or 3/4J and negative after a delay of 5/4J, identifies it as due to NH groups and thus backbone amides (Fig. 3, Table 2). By contras ...
Nicotinamide adenine dinucleotide, a metabolic regulator of
... Reported ratios of total intracellular NAD : NADH are: 4–10 in Escherichia coli [31,32]; 3–10 in mammals [33,34]; 3 in yeast [15]. These values suggest that NAD can function as a metabolic regulator of the NAD : NADH ratio. Although the ratios of total (i.e. free þ bound) NAD to total NADH in diffe ...
... Reported ratios of total intracellular NAD : NADH are: 4–10 in Escherichia coli [31,32]; 3–10 in mammals [33,34]; 3 in yeast [15]. These values suggest that NAD can function as a metabolic regulator of the NAD : NADH ratio. Although the ratios of total (i.e. free þ bound) NAD to total NADH in diffe ...
Application of Synthetic Biology for Biopolymer
... crude oil and are not biodegradable, their production leads to the depletion of fossil fuels and the accumulation of enormous amounts of plastic waste that pollutes ecosystems worldwide. For this reason, the European Union and other organisations are investing in research aimed at developing eco-fri ...
... crude oil and are not biodegradable, their production leads to the depletion of fossil fuels and the accumulation of enormous amounts of plastic waste that pollutes ecosystems worldwide. For this reason, the European Union and other organisations are investing in research aimed at developing eco-fri ...
CYP 2D6 Polymorphism
... „Every human differs (more or less) “ The phenotype can be distinguished by the actual activity or the amount of the expressed CYP enzyme. The genotype, however, is determined by the individual DNA sequence. Human: two sets of chromosomes That mean: The same genotype enables different phenotypes Dep ...
... „Every human differs (more or less) “ The phenotype can be distinguished by the actual activity or the amount of the expressed CYP enzyme. The genotype, however, is determined by the individual DNA sequence. Human: two sets of chromosomes That mean: The same genotype enables different phenotypes Dep ...
Cytochrome P450 and Polymorphism - uni
... „Every human differs (more or less) “ The phenotype can be distinguished by the actual activity or the amount of the expressed CYP enzyme. The genotype, however, is determined by the individual DNA sequence. Human: two sets of chromosomes ...
... „Every human differs (more or less) “ The phenotype can be distinguished by the actual activity or the amount of the expressed CYP enzyme. The genotype, however, is determined by the individual DNA sequence. Human: two sets of chromosomes ...
Interactions between carbohydrate and lipid metabolism in
... synthesizing these three types of substrates. The processes of oxidation and synthesis are ingeniously regulated. This thesis focuses on the interactions between carbohydrate and lipid metabolism, particularly related to the pathophysiology of glycogen storage disease and type II diabetes. Metabolic ...
... synthesizing these three types of substrates. The processes of oxidation and synthesis are ingeniously regulated. This thesis focuses on the interactions between carbohydrate and lipid metabolism, particularly related to the pathophysiology of glycogen storage disease and type II diabetes. Metabolic ...
Interactions between carbohydrate and lipid metabolism in
... synthesizing these three types of substrates. The processes of oxidation and synthesis are ingeniously regulated. This thesis focuses on the interactions between carbohydrate and lipid metabolism, particularly related to the pathophysiology of glycogen storage disease and type II diabetes. Metabolic ...
... synthesizing these three types of substrates. The processes of oxidation and synthesis are ingeniously regulated. This thesis focuses on the interactions between carbohydrate and lipid metabolism, particularly related to the pathophysiology of glycogen storage disease and type II diabetes. Metabolic ...
Dixie - ProjectWellbeing
... Director) was published on Valentine’s Day in 1994. The latest article was published in 2001. This collection consists of 44 items drawn from 26 newsletters. Only the newsletter pages with information on Down’s syndrome are included. Five of the items are full-length feature articles (typically 4-7 ...
... Director) was published on Valentine’s Day in 1994. The latest article was published in 2001. This collection consists of 44 items drawn from 26 newsletters. Only the newsletter pages with information on Down’s syndrome are included. Five of the items are full-length feature articles (typically 4-7 ...
principles of metabolic regulation: glucose and glycogen
... eukaryotic cell has the capacity to make about 30,000 different proteins, which catalyze thousands of different reactions involving many hundreds of metabolites, most shared by more than one “pathway.” This overview image of metabolic pathways is from the online KEGG (Kyoto Encyclopedia of Genes and ...
... eukaryotic cell has the capacity to make about 30,000 different proteins, which catalyze thousands of different reactions involving many hundreds of metabolites, most shared by more than one “pathway.” This overview image of metabolic pathways is from the online KEGG (Kyoto Encyclopedia of Genes and ...
Influence of oscillating dietary crude protein concentration on
... 0.04) DMI than steers fed the other dietary treatments. However, at the conclusion of the feeding study, steers fed the 14% CP diet had greater (P = 0.04) ADG and tended (P = 0.09) to have greater gain:feed than steers fed the 12% CP diet. Steers fed the oscillating CP regimen had intermediate perfo ...
... 0.04) DMI than steers fed the other dietary treatments. However, at the conclusion of the feeding study, steers fed the 14% CP diet had greater (P = 0.04) ADG and tended (P = 0.09) to have greater gain:feed than steers fed the 12% CP diet. Steers fed the oscillating CP regimen had intermediate perfo ...
Different lipid A types in lipopolysaccharides of phototrophic and
... the phosphate groups at C-4 and C-1 by 4aminoarabinose and D-arabinofuranose, respectively. Interestingly, the genealogically more distant species, R. gelatinosus, can be differentiated from R. tenuis by the chain length of ester-bound fatty acids (R. gelatinosus: 12 : 0 and 14 : 0; R. tenuis: 12:0 ...
... the phosphate groups at C-4 and C-1 by 4aminoarabinose and D-arabinofuranose, respectively. Interestingly, the genealogically more distant species, R. gelatinosus, can be differentiated from R. tenuis by the chain length of ester-bound fatty acids (R. gelatinosus: 12 : 0 and 14 : 0; R. tenuis: 12:0 ...
Sucrose breakdown in the potato tuber - publish.UP
... Institute of Biochemistry and Biology, Potsdam University, Germany ...
... Institute of Biochemistry and Biology, Potsdam University, Germany ...
Lactic acidosis - Medical School
... about the biochemistry and regulation of lactate metabolism have allowed a better understanding of the pathophysiology of the clinical disorder. Regretfully, progress in treatment has not kept pace, and all too often the development of lactic acidosis heralds a fatal outcome, as in the patient prese ...
... about the biochemistry and regulation of lactate metabolism have allowed a better understanding of the pathophysiology of the clinical disorder. Regretfully, progress in treatment has not kept pace, and all too often the development of lactic acidosis heralds a fatal outcome, as in the patient prese ...
- Surrey Research Insight Open Access
... C. tetani is the causative agent of tetanus; a disease which has been documented throughout history with records dating back to early Greek physicians over 2000 years ago (Humeau et al, 2000). The characteristics of the disease are very recognisable; severe and debilitating spastic paralysis as a re ...
... C. tetani is the causative agent of tetanus; a disease which has been documented throughout history with records dating back to early Greek physicians over 2000 years ago (Humeau et al, 2000). The characteristics of the disease are very recognisable; severe and debilitating spastic paralysis as a re ...
Anaerobic and aerobic pathways for salvage of proximal tubules
... the recovery of cell ATP concentration and ⌬⌿m during reoxygenation. These studies were designed not only to further delineate the mechanisms of mitochondrial damage and protection, but also to provide information bearing on the likelihood of their expression during proximal tubule injury in vivo, w ...
... the recovery of cell ATP concentration and ⌬⌿m during reoxygenation. These studies were designed not only to further delineate the mechanisms of mitochondrial damage and protection, but also to provide information bearing on the likelihood of their expression during proximal tubule injury in vivo, w ...
Targeting apicoplasts in malaria parasites
... small molecule inhibitors in Plasmodium [50]. Clearly, there are opportunities to employ other MEP pathway inhibitors against the parasite. The MEP pathway continues to be of interest as an antibiotic, and possibly a herbicide [51], and there are significant opportunities to use compounds identified ...
... small molecule inhibitors in Plasmodium [50]. Clearly, there are opportunities to employ other MEP pathway inhibitors against the parasite. The MEP pathway continues to be of interest as an antibiotic, and possibly a herbicide [51], and there are significant opportunities to use compounds identified ...
Developement of strategies for the isotopic labeling of methyl
... enhances the intensity of detectable long-range nOes by a factor 4. The described protocol also permits the suppression of spurious correlations, especially harmful for structural studies based on detection/analysis of nOes. To make an efficient use of the obtained high quality NMR spectra using thi ...
... enhances the intensity of detectable long-range nOes by a factor 4. The described protocol also permits the suppression of spurious correlations, especially harmful for structural studies based on detection/analysis of nOes. To make an efficient use of the obtained high quality NMR spectra using thi ...
Citrate metabolism in lactic acid bacteria
... duction of diacetyl. This pathway was broadly accepted, up to the 1980s [25,26,27], although the biochemical evidence supporting its existence remained scarce and the 'diacetyl synthase' had never been identified. In another school of thought [28,29] it is assumed that the production of C4 compounds ...
... duction of diacetyl. This pathway was broadly accepted, up to the 1980s [25,26,27], although the biochemical evidence supporting its existence remained scarce and the 'diacetyl synthase' had never been identified. In another school of thought [28,29] it is assumed that the production of C4 compounds ...
PAS kinase is required for normal cellular energy
... ecause of changes in diet and lifestyle, the incidence of obesity and type 2 diabetes is increasing dramatically worldwide. Type 2 diabetes arises when pancreatic -cells fail to secrete sufficient insulin to compensate for peripheral insulin resistance, a condition severely aggravated by obesity (1 ...
... ecause of changes in diet and lifestyle, the incidence of obesity and type 2 diabetes is increasing dramatically worldwide. Type 2 diabetes arises when pancreatic -cells fail to secrete sufficient insulin to compensate for peripheral insulin resistance, a condition severely aggravated by obesity (1 ...
Lab Handbook 1_5 - Central Manchester University Hospitals
... disorders. Mucopolysaccharidoses are initially screened by urinary MPS electrophoresis. Some disorders require specific tests not covered in the screen. These disorders include Pompe, Niemann-Pick type C and sialidosis. Where the enzyme and MPS screens are negative but there is evidence of an underl ...
... disorders. Mucopolysaccharidoses are initially screened by urinary MPS electrophoresis. Some disorders require specific tests not covered in the screen. These disorders include Pompe, Niemann-Pick type C and sialidosis. Where the enzyme and MPS screens are negative but there is evidence of an underl ...
Regulation of Urea Synthesis by Agmatine in the Perfused Liver
... adrenal chromaffin cells by binding to _ 2 -adrenergic receptors (14). Thus, agmatine, which is widely distributed in mammalian tissue (37, 39), may have a role as a hormone and/or polyamine precursor for a multiple metabolic functions. However, the significance of agmatine as a signaling molecule i ...
... adrenal chromaffin cells by binding to _ 2 -adrenergic receptors (14). Thus, agmatine, which is widely distributed in mammalian tissue (37, 39), may have a role as a hormone and/or polyamine precursor for a multiple metabolic functions. However, the significance of agmatine as a signaling molecule i ...
Lactic Acidosis: Recognition, Kinetics, and Associated Prognosis
... 100% mortality in surgical ICU patients who had persistently elevated lactate levels. Those who cleared their lactate (lactate level <2 mmol/L) in the first 24 hours had a mortality of 3.9%. Patients who had delayed lactate clearance (>48 hours to lactate level <2 mmol/L) had a mortality of 42.5%. H ...
... 100% mortality in surgical ICU patients who had persistently elevated lactate levels. Those who cleared their lactate (lactate level <2 mmol/L) in the first 24 hours had a mortality of 3.9%. Patients who had delayed lactate clearance (>48 hours to lactate level <2 mmol/L) had a mortality of 42.5%. H ...