UAB DIVISION of Molecular and Cellular Pathology
... Metabolomics in Nutrition Research • Relative to pharmacology and toxicology – Infancy – Similar goals • Identify those molecules that make a difference between “treatments” ...
... Metabolomics in Nutrition Research • Relative to pharmacology and toxicology – Infancy – Similar goals • Identify those molecules that make a difference between “treatments” ...
Metabolomic Profiling of Dynamic and Basal Measures of Glucose
... Associate Professor, Department of Biochemistry Dr. Allred is a molecular biologist with a research focus on understanding the genetic architecture of complex diseases and underlying risk factors in minority populations. With an emphasis on metabolic disease, her research concentration is on diabete ...
... Associate Professor, Department of Biochemistry Dr. Allred is a molecular biologist with a research focus on understanding the genetic architecture of complex diseases and underlying risk factors in minority populations. With an emphasis on metabolic disease, her research concentration is on diabete ...
1 - JACC
... present in the gut must also be taken into consideration when defining the human metabolome. The metabolome spans a variety of chemical compound classes, including those that are anionic versus cationic and lipophilic versus hydrophilic (Table 1). Metabolites in tissue or body fluids are present acr ...
... present in the gut must also be taken into consideration when defining the human metabolome. The metabolome spans a variety of chemical compound classes, including those that are anionic versus cationic and lipophilic versus hydrophilic (Table 1). Metabolites in tissue or body fluids are present acr ...
Title: MS and genome based methods to identify novel bacterial
... derived from microorganisms, the challenge today is that “the low hanging fruit” has been harvested and consequently methods need to be developed to increase chances to detect truly novel metabolites from complex crude extracts of bacterial cell growth. I will present our recent work aiming at a com ...
... derived from microorganisms, the challenge today is that “the low hanging fruit” has been harvested and consequently methods need to be developed to increase chances to detect truly novel metabolites from complex crude extracts of bacterial cell growth. I will present our recent work aiming at a com ...
investigation of the in-vitro metabolites of etodolac using
... In the present study, the metabolic profile of Etodolac was investigated in two in-vitro models and the tentative structure of the metabolites obtained was elucidated, employing LC-MS/MS technique. Mainly phase-I metabolic changes were observed including Hydrogenation (m/z 290), Methylation (m/z ...
... In the present study, the metabolic profile of Etodolac was investigated in two in-vitro models and the tentative structure of the metabolites obtained was elucidated, employing LC-MS/MS technique. Mainly phase-I metabolic changes were observed including Hydrogenation (m/z 290), Methylation (m/z ...
Stable Isotopes-Resolved Metabolomics (SIRM) Core
... Specific Aim 1. To implement and further develop high-informationthroughput (HIT) profiling of stable isotope-labeling patterns in metabolites using FT-ICR-MS and NMR- the SIRM approach Specific Aim 2. To build atom-resolved human metabolic network and chemical moiety-based non-steady state metaboli ...
... Specific Aim 1. To implement and further develop high-informationthroughput (HIT) profiling of stable isotope-labeling patterns in metabolites using FT-ICR-MS and NMR- the SIRM approach Specific Aim 2. To build atom-resolved human metabolic network and chemical moiety-based non-steady state metaboli ...
Document
... Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908 ...
... Patnaik, R. and Liao, J. (1994). "Engineering of Escherichia coli central metabolism for aromatic metabolite production with near theoretical yield". Appl. Environ. Microbiol. 60(11):3903-3908 ...
Top Ten Things to Know Potential Impact and Study Considerations
... Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease 1. Metabolomics, among the most recently emerged “omics” fields, involves the systematic measure and study of small molecule metabolites across biological systems using biosamples that include plasma, urin ...
... Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease 1. Metabolomics, among the most recently emerged “omics” fields, involves the systematic measure and study of small molecule metabolites across biological systems using biosamples that include plasma, urin ...
Metabolomics Research Core
... mathematical tools (e.g., Umetrics, Spotfire, SAS) to identify data trends that show the correlation of specific signals with the phenotypic response under investigation. Identified signals are mapped to biochemical pathways through the use of specialized software such as GeneGo, and expert biochemi ...
... mathematical tools (e.g., Umetrics, Spotfire, SAS) to identify data trends that show the correlation of specific signals with the phenotypic response under investigation. Identified signals are mapped to biochemical pathways through the use of specialized software such as GeneGo, and expert biochemi ...
Document
... No valid guidelines for quantitation of endogenous metabolites (FDA guidance was developed for xenobiotics) Nomenclature vs. analytical reality (sum signals, isomers, etc.) Normalization Absolute quantitation overcomes the need for analytical normalization Role of sample types (plasma, CSF ...
... No valid guidelines for quantitation of endogenous metabolites (FDA guidance was developed for xenobiotics) Nomenclature vs. analytical reality (sum signals, isomers, etc.) Normalization Absolute quantitation overcomes the need for analytical normalization Role of sample types (plasma, CSF ...
Stable Isotope and Metabolomics Core Facility
... The Einstein Stable Isotope & Metabolomics Core is within the NIH funded Diabetes Research Center at Einstein and anchors the CMCR Metabolomics Core. The Core uses stable isotope flux and metabolite profiling to help formulate and test hypotheses about the metabolic consequences of various changes i ...
... The Einstein Stable Isotope & Metabolomics Core is within the NIH funded Diabetes Research Center at Einstein and anchors the CMCR Metabolomics Core. The Core uses stable isotope flux and metabolite profiling to help formulate and test hypotheses about the metabolic consequences of various changes i ...
Abstract_Metabolomic_RFMF
... Solarix 7.0T (Bruker Daltonics, Bremen, Germany). In order to perform at a higher spectral resolution, spectra were performed using Full Scan and CASI (Continuous Accumulation of Selected Ions) mode between 100 and 600 Da, each windows corresponding to 100 Da. After data treatments, a list of metabo ...
... Solarix 7.0T (Bruker Daltonics, Bremen, Germany). In order to perform at a higher spectral resolution, spectra were performed using Full Scan and CASI (Continuous Accumulation of Selected Ions) mode between 100 and 600 Da, each windows corresponding to 100 Da. After data treatments, a list of metabo ...
Format of Abstract and CV - World DNA and Genome Day
... recognized expert in the use of liquid chromatography with mass spectrometry, capillary scale LC, purifications scale LC and metabonomics, giving many invited papers at international meetings around the world. After obtaining an Honors Degree in Chemistry from the University of Hertfordshire in 1992 ...
... recognized expert in the use of liquid chromatography with mass spectrometry, capillary scale LC, purifications scale LC and metabonomics, giving many invited papers at international meetings around the world. After obtaining an Honors Degree in Chemistry from the University of Hertfordshire in 1992 ...
Title: A Human Tumor Genome Project: From
... metabolomics and metabolite identification. He is a recognized expert in the use of liquid chromatography with mass spectrometry, capillary scale LC, purifications scale LC and metabonomics, giving many invited papers at international meetings around the world. After obtaining an Honors Degree in Ch ...
... metabolomics and metabolite identification. He is a recognized expert in the use of liquid chromatography with mass spectrometry, capillary scale LC, purifications scale LC and metabonomics, giving many invited papers at international meetings around the world. After obtaining an Honors Degree in Ch ...
Title: A Human Tumor Genome Project: From Sequence to Structure
... recognized expert in the use of liquid chromatography with mass spectrometry, capillary scale LC, purifications scale LC and metabonomics, giving many invited papers at international meetings around the world. After obtaining an Honors Degree in Chemistry from the University of Hertfordshire in 1992 ...
... recognized expert in the use of liquid chromatography with mass spectrometry, capillary scale LC, purifications scale LC and metabonomics, giving many invited papers at international meetings around the world. After obtaining an Honors Degree in Chemistry from the University of Hertfordshire in 1992 ...
IB496-May 2
... leads to the destruction of adenine nucleotide (phosphates) which leads to a decline in NAD/NADP. ...
... leads to the destruction of adenine nucleotide (phosphates) which leads to a decline in NAD/NADP. ...
