A Database of Peak Annotations of Empirically Derived Mass Spectra
... Mass spectrometry has generated vast amounts of data and is the central technology in proteomics research. Presently, several databases containing empirically derived tandem mass spectrum (MS/MS) data are publicly available. These can be used singly or in a concatenated fashion; together they contai ...
... Mass spectrometry has generated vast amounts of data and is the central technology in proteomics research. Presently, several databases containing empirically derived tandem mass spectrum (MS/MS) data are publicly available. These can be used singly or in a concatenated fashion; together they contai ...
Mass spectrometry
... to accelerate molecular ions and, thus, the method does not measure the mass of a molecule per se, but rather the mass-to-charge (m/Z) ratio of the molecular ion. • We will see that molecular ions with smaller masses or larger numbers of charges will have a higher velocity, and this can be used as a ...
... to accelerate molecular ions and, thus, the method does not measure the mass of a molecule per se, but rather the mass-to-charge (m/Z) ratio of the molecular ion. • We will see that molecular ions with smaller masses or larger numbers of charges will have a higher velocity, and this can be used as a ...
Analytical Ultracentrifugation
... a broad range of solvents. In AUC, molecules are characterized directly in solution, often under biologically relevant conditions. In contrast to many other methods, there are no complications caused by interactions with matrices or surfaces. Also, no immobilization or labeling is necessary for the ...
... a broad range of solvents. In AUC, molecules are characterized directly in solution, often under biologically relevant conditions. In contrast to many other methods, there are no complications caused by interactions with matrices or surfaces. Also, no immobilization or labeling is necessary for the ...
here - Solve ME/CFS Initiative
... Maybe something more at work. Reduced amino acids in feces appears linked to altered energy metabolism in ME/CFS. ...
... Maybe something more at work. Reduced amino acids in feces appears linked to altered energy metabolism in ME/CFS. ...
lab presentation - Fonds Wetenschappelijk Onderzoek
... 4. Train young scientists in a multidisciplinary attitude (complexity of genotype x environment x management) ...
... 4. Train young scientists in a multidisciplinary attitude (complexity of genotype x environment x management) ...
lab presentation
... 4. Train young scientists in a multidisciplinary attitude (complexity of genotype x environment x management) ...
... 4. Train young scientists in a multidisciplinary attitude (complexity of genotype x environment x management) ...
Supplementary 1: Material and methods Determination of CHO cell
... network model by adding reactions obtained from CHO cDNA annotation resulting in the addition of 38 new reactions from various metabolic subsystems (see supplementary 1 for list of reactions). We also examined the model for missing links and improved the network connectivity by filling the gaps with ...
... network model by adding reactions obtained from CHO cDNA annotation resulting in the addition of 38 new reactions from various metabolic subsystems (see supplementary 1 for list of reactions). We also examined the model for missing links and improved the network connectivity by filling the gaps with ...
15_intro-to
... pathway in a steady state is more or less constant • A steady state far from equilibrium is thermodynamically efficient because only a nonequilibrium process can perform work • The flux of intermediates in a pathway is set by the rate-determining step ...
... pathway in a steady state is more or less constant • A steady state far from equilibrium is thermodynamically efficient because only a nonequilibrium process can perform work • The flux of intermediates in a pathway is set by the rate-determining step ...
No Slide Title
... Categorising methods (Giuseppin and van Riel) “Engineering” approach: Input and output fluxes are measured and used to determine the internal net fluxes through the metabolic pathways. These methods are static; they describe fluxes at given conditions and do not allow for extrapolation to other con ...
... Categorising methods (Giuseppin and van Riel) “Engineering” approach: Input and output fluxes are measured and used to determine the internal net fluxes through the metabolic pathways. These methods are static; they describe fluxes at given conditions and do not allow for extrapolation to other con ...
Gene Ontology (GO)
... KEGG pathways • KEGG PATHWAYS: – collection of manually drawn pathway maps representing our knowledge on the molecular interaction and reaction networks, for a large selection of organisms ...
... KEGG pathways • KEGG PATHWAYS: – collection of manually drawn pathway maps representing our knowledge on the molecular interaction and reaction networks, for a large selection of organisms ...
Metabolomic Profiling Identifies Biomarkers Associated
... Baseline fasting plasma samples from the cases and controls underwent non-targeted metabolomic profiling. Plasma samples were extracted with methanol and analyzed by gas chromatography-mass spectrometry and S' ultra high performance liquid chromatography-tandem mass spectrometry. Two-way ANOVA with ...
... Baseline fasting plasma samples from the cases and controls underwent non-targeted metabolomic profiling. Plasma samples were extracted with methanol and analyzed by gas chromatography-mass spectrometry and S' ultra high performance liquid chromatography-tandem mass spectrometry. Two-way ANOVA with ...
Flexibility in energy metabolism supports hypoxia tolerance in
... Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis Jacob Feala1,2 Laurence Coquin, PhD2 Andrew McCulloch, PhD1 Giovanni Paternostro, PhD1,2 1) UCSD Bioengineering 2) Burnham Institute for Medical Research ...
... Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis Jacob Feala1,2 Laurence Coquin, PhD2 Andrew McCulloch, PhD1 Giovanni Paternostro, PhD1,2 1) UCSD Bioengineering 2) Burnham Institute for Medical Research ...
Chapter 2: Target/decoy search strategy for increased
... reconditioning wash (100 % buffer A, 50 minutes). Eluting peptides were measured by the LTQ FT mass spectrometer (ThermoElectron, San Jose, CA) operating in a datadependent mode. For the Jurkat sample, eight ion-trap MS/MS spectra were acquired ...
... reconditioning wash (100 % buffer A, 50 minutes). Eluting peptides were measured by the LTQ FT mass spectrometer (ThermoElectron, San Jose, CA) operating in a datadependent mode. For the Jurkat sample, eight ion-trap MS/MS spectra were acquired ...
Metabolic-pathway– directed targeted metabolomics
... decade and has taken its place in the list of established OMICS topics in biology. However, the growing number of detectable and identifiable substances increases the need for efficient data analysis and interpretation. Metabolic pathways enable biologists to structure and link biochemical processes ...
... decade and has taken its place in the list of established OMICS topics in biology. However, the growing number of detectable and identifiable substances increases the need for efficient data analysis and interpretation. Metabolic pathways enable biologists to structure and link biochemical processes ...
Systems Biology Study Group Chapter 3
... • Conformational changes in enzyme molecule • Example: Hexokinase – Catalyzes phosphorylation of glucose – Inhibited by ATP, product of glycolysis – Stimulated by ADP, product of ATP stored energy consumption ...
... • Conformational changes in enzyme molecule • Example: Hexokinase – Catalyzes phosphorylation of glucose – Inhibited by ATP, product of glycolysis – Stimulated by ADP, product of ATP stored energy consumption ...
Metabolism of Xenobiotics
... uncover functional groups on a xenobiotic that provide sites for Phase II metabolism OH ...
... uncover functional groups on a xenobiotic that provide sites for Phase II metabolism OH ...
1.3.7 Metabolic Role of Biomolecules
... All enzymes are proteins and have a folded shape. Enzymes control the chemical reactions in cells. e.g. enzymes control the processes of photosynthesis and respiration Chlorophyll is a protein that traps the sun’s energy during photosynthesis ...
... All enzymes are proteins and have a folded shape. Enzymes control the chemical reactions in cells. e.g. enzymes control the processes of photosynthesis and respiration Chlorophyll is a protein that traps the sun’s energy during photosynthesis ...
A New Deoxyisoaustamide Derivative from the Marine
... C22H24N3O4, 394.1767). The 1H NMR spectrum of 3 showed signals for an NH proton at δH 10.72 (1H, s), an 1,2disubstituted aromatic ring [δH 6.89 (1H, ddd, J = 1.2, 6.4, 7.2 Hz), 6.94 (1H, ddd, J = 1.2, 6.4, 7.2 Hz), 7.19 (1H, d, J = 7.2 Hz), and 7.32 (1H, d, 7.2 Hz)], suggesting that compound 1 posse ...
... C22H24N3O4, 394.1767). The 1H NMR spectrum of 3 showed signals for an NH proton at δH 10.72 (1H, s), an 1,2disubstituted aromatic ring [δH 6.89 (1H, ddd, J = 1.2, 6.4, 7.2 Hz), 6.94 (1H, ddd, J = 1.2, 6.4, 7.2 Hz), 7.19 (1H, d, J = 7.2 Hz), and 7.32 (1H, d, 7.2 Hz)], suggesting that compound 1 posse ...
Metabolism of xenobiotics I (general overview)
... • Phase II: Synthetic reaction of a xenobiotic (or of a Phase I metabolite of a xenobiotic) with an endogenous substance that results in introduction of polar, ionizable groups to enhance water solubility and hence excretion COOH ...
... • Phase II: Synthetic reaction of a xenobiotic (or of a Phase I metabolite of a xenobiotic) with an endogenous substance that results in introduction of polar, ionizable groups to enhance water solubility and hence excretion COOH ...
Biosynthesis of Plant Primary metabolites
... derived biosynthetically from primary metabolites. These are organic compounds that are not directly involved in the normal growth, development, or not necessary for the plant cells themselves but may be useful for the plant as a whole. Since these don’t have primary function so they are called seco ...
... derived biosynthetically from primary metabolites. These are organic compounds that are not directly involved in the normal growth, development, or not necessary for the plant cells themselves but may be useful for the plant as a whole. Since these don’t have primary function so they are called seco ...
Identification of Drug Metabolites via Mass Spectrometry Besnik
... D.Q. Liu, C.E.C.A. Hop / Journal of Pharmaceutical and Biomedical Analysis ...
... D.Q. Liu, C.E.C.A. Hop / Journal of Pharmaceutical and Biomedical Analysis ...
Laboratory Technician-Bioanalytical Methods PLASMA PROTEIN
... Therapure Biopharma Inc. is a biopharmaceutical company focused on complex biological therapeutics and technologies. It is comprised of three divisions: Therapure Biomanufacturing which provides contract development and manufacturing (CDMO) services to global clients; Therapure Innovations, focused ...
... Therapure Biopharma Inc. is a biopharmaceutical company focused on complex biological therapeutics and technologies. It is comprised of three divisions: Therapure Biomanufacturing which provides contract development and manufacturing (CDMO) services to global clients; Therapure Innovations, focused ...
Lecture 1 - Edward Dennis - University of California San Diego
... Future of Clinical Medicine • Identification of metabolites in human plasma and other tissues for diagnostic purposes • Discovery of novel metabolites as biomarkers for disease states • Quantitation of metabolites which permit dynamic monitoring of disease pathophysiology over time • Evaluation of t ...
... Future of Clinical Medicine • Identification of metabolites in human plasma and other tissues for diagnostic purposes • Discovery of novel metabolites as biomarkers for disease states • Quantitation of metabolites which permit dynamic monitoring of disease pathophysiology over time • Evaluation of t ...