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d-amphetamine sulfate
d-amphetamine sulfate

... Therapeutic doses are in the range of 5 to 30 mg daily. Therapeutic blood concentrations are in the range of 0.03 to 0.04 mg/l. Doses over 1-2 g amphetamine or D-amphetamine sulfate can cause severe intoxication. Response is variable and tolerance develops in chronic abusers, who may use as much as ...
Elemental Analysis
Elemental Analysis

... similar outward effect. Using specific reagents and reactions, makes it possible to detect some elements in mixtures with a fractional method. For instance, starch is a specific reagent for iodine detection (a blue compound is formed), alkali is used for nitrogen detection in ammonia salts. Using di ...
Evolution & organisation of metabolic Pathways
Evolution & organisation of metabolic Pathways

... mixtures of proteins, lipids, carbohydrates: fixed composition Reserve(s) do complicate model & implications & testing Reasons to delineate reserve, distinct from structure • metabolic memory • biomass composition depends on growth rate • explanation of respiration patterns (freshly laid eggs don’t ...
Integration of Metabolism
Integration of Metabolism

... FA taken up from the circulation. ...
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Document

... their function is tightly regulated by Ca2+ concentrations • upon binding Ca2+, S100B(bb) undergoes a large conformational change which exposes a hydrophobic patch that is required for binding to p53 • the Ca2+ dependent interaction of p53 with dimeric S100B(bb) causes inhibition of p53 dependent tr ...
The FAH Fold Meets the Krebs Cycle
The FAH Fold Meets the Krebs Cycle

... investigated so far, ranging from yeast to human, it can be expected that the enzyme plays an important and evolutionary conserved role for the maintenance of mitochondrial function, presumably by safeguarding against excessive accumulation of oxaloacetate to prevent the inhibition of mitochondrial ...
Metabolic Disorders
Metabolic Disorders

... Maple syrup urine disease ( MSUD ) ...
UvA-DARE (Digital Academic Repository)
UvA-DARE (Digital Academic Repository)

... Abstract: Modifying substrate uptake systems is a potentially powerful tool in metabolic engineering. This research investigates energetic and metabolic changes brought about by the genetic modification of the glucose uptake and phosphorylation system of Escherichia coli. The engineered strain PPA31 ...
Principles of Chromatography File
Principles of Chromatography File

... • After five equilibrations, the compound is distributed throughout the whole column but is maximally concentrated at the center of the column. • If the distribution coefficient is <1 • More than 50% of the compound would be left on solid phase after each equilibration and the concentration peak is ...
Guidelines for the diagnosis of inherited metabolic disease in
Guidelines for the diagnosis of inherited metabolic disease in

... 12. Hoffman GF et al (1993) Clinical and Biochemical Phenotype in 11 Patients with Mevalonic Aciduria. Pediatrics 91:915-921 13. Brunetti-Pierri N et al (2002) X-linked recessive chondrodysplasia punctata:Spectrum of arylsulphatase E mutations and expanded clinical variability. Am.J.Med.Genet. 117A: ...
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for anti-viral therapy.
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for anti-viral therapy.

... Viruses rely on the metabolic network of their cellular hosts to provide energy and building blocks for viral replication. We developed a flux measurement approach based on liquid chromatography–tandem mass spectrometry to quantify changes in metabolic activity induced by human cytomegalovirus (HCMV ...
Overview of Metabolism - Chapter 4 - Formatted
Overview of Metabolism - Chapter 4 - Formatted

... metabolism. Every cell in a living organism works like an industrial organization. It is in a state of dynamic equilibrium, constantly taking in substances from its external environment, processing them, synthesizing its own requirements, degrading what is old or harmful, and sending out what it may ...
Professor Jason Raymond - School of Earth and Space Exploration
Professor Jason Raymond - School of Earth and Space Exploration

... • Eukaryotes (plants and algae) acquired photosynthesis via ...
Mass Spectrometry in the Clinical Laboratory
Mass Spectrometry in the Clinical Laboratory

... largely due to extraordinary advances in mass spectrometry (MS) developed in the previous decade.3 A clear vision of the importance of MS in medicine was provided at the 11th Sanibel Conference on Mass Spectrometry4 entitled “Mass Spectrometry in the Clinical Diagnosis of Disease”. The consensus of ...
MLTC 1500 MLT Urinalysis and Body Fluids Fall 2016
MLTC 1500 MLT Urinalysis and Body Fluids Fall 2016

... This is one of a series of technical courses for the Medical Laboratory Technology Program. This course is designed to develop the knowledge, competencies, critical thinking and useful, job-oriented skills in urinalysis and body fluids for laboratory testing and result correlation. It includes, at a ...
l a u n
l a u n

... Molecular scaffolds, due to the highly symmetric orientation, can serve as functional points of attachment. The relative positioning of these functional groups can have a profound effect on the aggregation, self-assembly and binding ability of these molecules. The derivatives of these scaffolds bear ...
CSU Agricultural Research Initiative
CSU Agricultural Research Initiative

... The published method is an alternative to other analytical techniques, with the additional advantages of low solvent consumption (milliliters per day vs. liters per day for HPLC), short time of analysis, no hazardous solvents, and low costs as compared with others (more than 1000 analysis were run w ...
Presentation @ 1:30 - Bioinformatics at School of Informatics
Presentation @ 1:30 - Bioinformatics at School of Informatics

... Sensitivity-Specificity and Accuracy-AUC for all charges in all ions on Cross ...
Anion gap metabolic acidosis
Anion gap metabolic acidosis

...  Acetaldehyde levels increase significantly if acetaldehyde dehydrogenase inhibited by disulfiram, insecticides or a sulfonurea. ...
Determination of Active Ingredients in Commercial Bleach and Vinegar
Determination of Active Ingredients in Commercial Bleach and Vinegar

... 1. Demonstrate the analysis of common chemicals using titration technique. 2. Explain the concept of quantitative analysis. 3. Quantitatively determine the amounts in an unknown using standard solutions. 4. Demonstrate the understanding of redox titrations. ...
MLTC 1500 MLT Urinalysis and Body Fluids Syllabus
MLTC 1500 MLT Urinalysis and Body Fluids Syllabus

... This is one of a series of technical courses for the Medical Laboratory Technology Program. This course is designed to develop the knowledge, competencies, critical thinking and useful, job-oriented skills in urinalysis and body fluids for laboratory testing and result correlation. It includes, at a ...
2. Large-scale Metabolic Reconstruction
2. Large-scale Metabolic Reconstruction

... Genome-scale metabolic network models (GSMs) are useful tools to represent and analyze the metabolism of an organism. They are information infrastructures containing chemically accurate descriptions of the cellular reactions and known geneproteinreaction associations [11]. GSM provides a context t ...
Protein Sequencing Submission Form
Protein Sequencing Submission Form

... PROTEIN/PEPTIDE SEQUENCE ANALYSIS SUBMISSION FORM ...
Using NMR Metabolomics to Investigate Tricarboxylic Acid Cycle
Using NMR Metabolomics to Investigate Tricarboxylic Acid Cycle

... was assessed (Fig. 1). As expected, iron-limited growth and ethanol stress prevented the post-exponential growth phase increase in the specific activity of the iron-requiring enzyme aconitase, creating a metabolic block in the TCA cycle (Fig. 1). Although ethanol-stressed bacteria are in the post-ex ...
Guideline for the investigation of hyperammonaemia
Guideline for the investigation of hyperammonaemia

... The most common cause of raised plasma ammonia is artefactual due to poor sample collection or a delay in analysis. Plasma ammonia levels should be taken from a free flowing venous sample and should be taken directly to the biochemistry laboratory. It is important to inform the laboratory that an am ...
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Metabolomics

Metabolomics is the scientific study of chemical processes involving metabolites. Specifically, metabolomics is the ""systematic study of the unique chemical fingerprints that specific cellular processes leave behind"", the study of their small-molecule metabolite profiles. The metabolome represents the collection of all metabolites in a biological cell, tissue, organ or organism, which are the end products of cellular processes. mRNA gene expression data and proteomic analyses reveal the set of gene products being produced in the cell, data that represents one aspect of cellular function. Conversely, metabolic profiling can give an instantaneous snapshot of the physiology of that cell. One of the challenges of systems biology and functional genomics is to integrate proteomic, transcriptomic, and metabolomic information to provide a better understanding of cellular biology.
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