SSTOP drugs Word file
... Appendix 1: STOPP (Screening Tool of Older People’s potentially inappropriate Prescriptions). The following prescriptions are potentially inappropriate in persons aged 65 years of age A. ...
... Appendix 1: STOPP (Screening Tool of Older People’s potentially inappropriate Prescriptions). The following prescriptions are potentially inappropriate in persons aged 65 years of age A. ...
Adverse effects
... causes pupillary dilation, increased blood pressure, and increased body temperature. Adverse effects include nausea, and muscular weakness. low doses of LSD can induce hallucinations, High doses may produce longlasting psychotic changes in susceptible individuals. Haloperidol and other neuroleptics ...
... causes pupillary dilation, increased blood pressure, and increased body temperature. Adverse effects include nausea, and muscular weakness. low doses of LSD can induce hallucinations, High doses may produce longlasting psychotic changes in susceptible individuals. Haloperidol and other neuroleptics ...
Neurotoxicity: Identifying and Controlling Poisons of the Nervous
... Hydrophobic: Insoluble in water; these substances may also be termed lipophilic. Inert ingredient (of a pesticide): The solvent or “inactive” solid that dilutes or carries a pesticide; inert ingredients are so called because they have no effect on the targeted pest, not because they are inherently i ...
... Hydrophobic: Insoluble in water; these substances may also be termed lipophilic. Inert ingredient (of a pesticide): The solvent or “inactive” solid that dilutes or carries a pesticide; inert ingredients are so called because they have no effect on the targeted pest, not because they are inherently i ...
What is PK/PD modeling? - Physiologie et Thérapeutique Ecole
... • The doses recommended for small animals are too high. – Such recommendations for salicylates were rather constant in veterinary pharmacology handbooks in e.g. Germany, USA, Russia and Spain from 1900 up to the 70’s. ...
... • The doses recommended for small animals are too high. – Such recommendations for salicylates were rather constant in veterinary pharmacology handbooks in e.g. Germany, USA, Russia and Spain from 1900 up to the 70’s. ...
EVALUATION OF HEPATOPROTECTIVE AND ANTIOXIDANT ACTIVITY OF HEXAGAMAVUNON1 AGAINST CARBON TETRACHLORIDEINDUCED HEPATIC INJURY IN
... marker enzymes, which are released from liver into the blood 1. The determination of enzyme levels in assessment of CCl4‐induced liver damage, such as SGPT and SGOT is largely used. The membrane damage releases the enzyme into circulation. SGPT catalyses the conversion of a ...
... marker enzymes, which are released from liver into the blood 1. The determination of enzyme levels in assessment of CCl4‐induced liver damage, such as SGPT and SGOT is largely used. The membrane damage releases the enzyme into circulation. SGPT catalyses the conversion of a ...
View/Open
... 1. Use of long-term powerful opiates e.g. morphine or fentanyl as first line therapy for mild-moderate pain (WHO analgesic ladder not observed). 2. Regular opiates for more than 2 weeks in those with chronic constipation without concurrent use of laxatives (risk of severe constipation). 3. Long-ter ...
... 1. Use of long-term powerful opiates e.g. morphine or fentanyl as first line therapy for mild-moderate pain (WHO analgesic ladder not observed). 2. Regular opiates for more than 2 weeks in those with chronic constipation without concurrent use of laxatives (risk of severe constipation). 3. Long-ter ...
A. Cardiovascular System 1. Digoxin at a long
... 1. Use of long-term powerful opiates e.g. morphine or fentanyl as first line therapy for mild-moderate pain (WHO analgesic ladder not observed). 2. Regular opiates for more than 2 weeks in those with chronic constipation without concurrent use of laxatives (risk of severe constipation). 3. Long-ter ...
... 1. Use of long-term powerful opiates e.g. morphine or fentanyl as first line therapy for mild-moderate pain (WHO analgesic ladder not observed). 2. Regular opiates for more than 2 weeks in those with chronic constipation without concurrent use of laxatives (risk of severe constipation). 3. Long-ter ...
hepatoprotective activity of root bark of azima tetracantha lam
... hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, alkaline phosphatase (ALP) and acid phosphatase (ACP), also total bilirubin along with histopathological studies of liver tissue. The biochemical changes and histopathological studies were observed on 8 t ...
... hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, alkaline phosphatase (ALP) and acid phosphatase (ACP), also total bilirubin along with histopathological studies of liver tissue. The biochemical changes and histopathological studies were observed on 8 t ...
see p. Psy15 - Viktor`s Notes for the Neurosurgery Resident
... Advantages of TCAs – low cost. Disadvantages of TCAs – need to titrate dose to therapeutic level, considerable toxicity in overdose. PHARMACOKINETICS TCAs are well absorbed per os. lipophilic - readily penetrate into CNS, long T½ (e.g. 4-17 hours for IMIPRAMINE). divided doses may minimize sid ...
... Advantages of TCAs – low cost. Disadvantages of TCAs – need to titrate dose to therapeutic level, considerable toxicity in overdose. PHARMACOKINETICS TCAs are well absorbed per os. lipophilic - readily penetrate into CNS, long T½ (e.g. 4-17 hours for IMIPRAMINE). divided doses may minimize sid ...
Endocrine Disorders Parathyroid Gland
... Calcium levels are over 10mg/dL Phosphorus is less than 3 mg/dL DEXA scans MRI, CT for tumor screening Treatment depends on severity ...
... Calcium levels are over 10mg/dL Phosphorus is less than 3 mg/dL DEXA scans MRI, CT for tumor screening Treatment depends on severity ...
No Slide Title
... MCASE-ES false positives are not correctable {model is flawed; whimsical predictions of chemical toxicity} ...
... MCASE-ES false positives are not correctable {model is flawed; whimsical predictions of chemical toxicity} ...
Ecotoxicology: An Opportunity for the Experimental
... Screening or range-finding tests should provide two useful types of information. (1) Such tests should determine whether the environmental concentration of the chemical is well below the concentration causing adverse biological effects, above that concentration, or in such close proximity that more ...
... Screening or range-finding tests should provide two useful types of information. (1) Such tests should determine whether the environmental concentration of the chemical is well below the concentration causing adverse biological effects, above that concentration, or in such close proximity that more ...
Barbiturate
... all but the milder forms of situational insomnia. Furthermore, they have numerous undesirable side effects (such as anticholinergic effects) that make them less useful than the benzodiazepines. Some sedative antihistamines are marketed in numerous over-the-counter products. Ethanol has anxiolytic an ...
... all but the milder forms of situational insomnia. Furthermore, they have numerous undesirable side effects (such as anticholinergic effects) that make them less useful than the benzodiazepines. Some sedative antihistamines are marketed in numerous over-the-counter products. Ethanol has anxiolytic an ...
Determinants of Neonatal Cardiac Output
... – D causes 10% decrease LV output secondary to drop in LV stroke volume; E increases LV output by 10% due to increase in LVS – Conclusion: “Epinephrine has better effect on contractility” ...
... – D causes 10% decrease LV output secondary to drop in LV stroke volume; E increases LV output by 10% due to increase in LVS – Conclusion: “Epinephrine has better effect on contractility” ...
Slide 1
... • Ecosystem: A biological community and all of the abiotic factors that affect it. • Biome: A large group of ecosystems that share the same climate and have similar types of communities. • Biosphere: All biomes together; the Earth ...
... • Ecosystem: A biological community and all of the abiotic factors that affect it. • Biome: A large group of ecosystems that share the same climate and have similar types of communities. • Biosphere: All biomes together; the Earth ...
Pharmacology MCQs
... slows down its dissociation from binding sites. favors elimination of high clearance drugs. implies a high volume of distribution. ...
... slows down its dissociation from binding sites. favors elimination of high clearance drugs. implies a high volume of distribution. ...
Anti depressant drugs
... imbedded in the axon terminal and cell body membrane of serotonergic neurons ...
... imbedded in the axon terminal and cell body membrane of serotonergic neurons ...
Adrenergic Agonists
... Epinephrine ≥ Norepinephrine >> Isoproterenol ……………….? This means that we need lower doses of NE or Epin. Than Isoproterenol, to produce the same effects. α1-receptors have a higher affinity for Phenylephrine than do α2-receptors. α2-receptors have a higher affinity for clonidine than do α1-receptor ...
... Epinephrine ≥ Norepinephrine >> Isoproterenol ……………….? This means that we need lower doses of NE or Epin. Than Isoproterenol, to produce the same effects. α1-receptors have a higher affinity for Phenylephrine than do α2-receptors. α2-receptors have a higher affinity for clonidine than do α1-receptor ...
Antimicrobial Fundamental Concepts
... microorganisms. In other words, if a drug is concentration dependent and bactericidal against one organism, that does not mean that it, or all the other drugs in its class, are concentration dependent and bactericidal against all organisms. However, because of a lack of data characterizing the pharm ...
... microorganisms. In other words, if a drug is concentration dependent and bactericidal against one organism, that does not mean that it, or all the other drugs in its class, are concentration dependent and bactericidal against all organisms. However, because of a lack of data characterizing the pharm ...
Title: Directly observable behavioral effects of lorcaserin in rats
... lorcaserin (F(1,7)=42.0; P=0.0003; Fig. 3, upper panels). WAY 100635 also attenuated 8-OHDPAT-induced flat body posture (i.e., maximal effect; F(1,7)=84.29; P<0.0001) and lower lip retraction (i.e. maximally effective dose; F(1,7)=91.93; P<0.0001; Fig. 3, middle and lower left panels, respectively). ...
... lorcaserin (F(1,7)=42.0; P=0.0003; Fig. 3, upper panels). WAY 100635 also attenuated 8-OHDPAT-induced flat body posture (i.e., maximal effect; F(1,7)=84.29; P<0.0001) and lower lip retraction (i.e. maximally effective dose; F(1,7)=91.93; P<0.0001; Fig. 3, middle and lower left panels, respectively). ...
Our work in prevention
... Methamphetamine is more quickly and fully absorbed by the brain than amphetamine, therefore the effects are stronger. Short term negative effects: State of agitation that can lead to violence; Inability to sleep, hallucinations; Weight loss (women might see it as a desirable effect); Par ...
... Methamphetamine is more quickly and fully absorbed by the brain than amphetamine, therefore the effects are stronger. Short term negative effects: State of agitation that can lead to violence; Inability to sleep, hallucinations; Weight loss (women might see it as a desirable effect); Par ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.