toxicology 3 - Calgary Emergency Medicine
... • Anitbiotix that cause Sz do so through GABA antagonism ...
... • Anitbiotix that cause Sz do so through GABA antagonism ...
Annexure A: Ethical approval 116
... hepatic lipid peroxidation, DNA damage, and excretion of urinary lipid metabolites. Free Radical Biology and Medicine 15(2):217-222. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. (1995) In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected p ...
... hepatic lipid peroxidation, DNA damage, and excretion of urinary lipid metabolites. Free Radical Biology and Medicine 15(2):217-222. Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. (1995) In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected p ...
Pituitary Hormones
... Hypothalamic lesion or removal → ↓ Ant. Pit H’s except PRL Hypothalamic stimulation → ↑ Ant. Pit H’s except PRL TSH ↑ T3 & T4 through ↑ cAMP, ↑ Iodine uptake ↑ iodination and hydrolysis of thyroglobulin ** diagnostic use ...
... Hypothalamic lesion or removal → ↓ Ant. Pit H’s except PRL Hypothalamic stimulation → ↑ Ant. Pit H’s except PRL TSH ↑ T3 & T4 through ↑ cAMP, ↑ Iodine uptake ↑ iodination and hydrolysis of thyroglobulin ** diagnostic use ...
H. Antifungal agents
... - Amphotericin is 10X more active which can be taken systemically. - Mechanism of action: have affinity to ergosterols containing membranes, ...
... - Amphotericin is 10X more active which can be taken systemically. - Mechanism of action: have affinity to ergosterols containing membranes, ...
Anxiolytic, hypnotic
... Amnestic effects have been reported with use of doses greater than recommended. It has a rapid onset of action, and its duration of hypnotic action is close to that of triazolam. minor effects on sleep patterns at the recommended hypnotic dose but can suppress REM sleep at higher doses. It may caus ...
... Amnestic effects have been reported with use of doses greater than recommended. It has a rapid onset of action, and its duration of hypnotic action is close to that of triazolam. minor effects on sleep patterns at the recommended hypnotic dose but can suppress REM sleep at higher doses. It may caus ...
The Role Of Preclinical Models In The Development Of Psychotropic
... cognitive fragmentation. The hypothetical construct of attentional filtering has been defined operationally and explored in multiple paradigms and in both human and animal studies. For example, numerous studies of schizophrenia patients have demonstrated deficits in behavioral habituation, which is ...
... cognitive fragmentation. The hypothetical construct of attentional filtering has been defined operationally and explored in multiple paradigms and in both human and animal studies. For example, numerous studies of schizophrenia patients have demonstrated deficits in behavioral habituation, which is ...
English - Hormone Health Network
... Human growth hormone (GH) is a substance that controls your body’s growth. GH is made by the pituitary gland, located at the base of the brain. GH helps children grow taller (also called linear growth), increases muscle mass, and decreases body fat. In both children and adults, GH also helps control ...
... Human growth hormone (GH) is a substance that controls your body’s growth. GH is made by the pituitary gland, located at the base of the brain. GH helps children grow taller (also called linear growth), increases muscle mass, and decreases body fat. In both children and adults, GH also helps control ...
Non-consumptive Predator Effects
... and thus realize no reproductive success, but in the long term, the day’s shortcomings may have minimal influence on lifetime fitness. Few failures, however, are as unforgiving as the failure to avoid a predator: being ...
... and thus realize no reproductive success, but in the long term, the day’s shortcomings may have minimal influence on lifetime fitness. Few failures, however, are as unforgiving as the failure to avoid a predator: being ...
CHAPTER 8 ANTIHYPERTENSIVE DRUGS Classification 1
... Contraindications include bilateral renal artery stenosis, pregnancy, known allergy, and hyperkalaemia. High serum creatinine (> 3 mg/dl) is an indication for careful monitoring of renal function, and potassium. Benefits can still be obtained in spite of renal insufficiency. A slight stable increase ...
... Contraindications include bilateral renal artery stenosis, pregnancy, known allergy, and hyperkalaemia. High serum creatinine (> 3 mg/dl) is an indication for careful monitoring of renal function, and potassium. Benefits can still be obtained in spite of renal insufficiency. A slight stable increase ...
Role of the Androgen Receptor in Human Breast Cancer
... content, as measured by radioligand binding and antiER monoclonal antibodies. These effects of DHT on breast cancer cell proliferation and receptor levels were reversed by the androgen receptor antagonist, hydroxyflutamide, indicating that they were mediated via an interaction with the AR (29). In v ...
... content, as measured by radioligand binding and antiER monoclonal antibodies. These effects of DHT on breast cancer cell proliferation and receptor levels were reversed by the androgen receptor antagonist, hydroxyflutamide, indicating that they were mediated via an interaction with the AR (29). In v ...
Cathartics/purgatives
... Diphenylyl methane Derivatives: Bisacodyl: Mechanism of Action: This agent is hydrolyzed in gut through deacetylation and converted to active form which produces low grade inflammation as a result of which motility and secretions are increased. Adverse Effects: Abdominal pain/discomfort, few allerg ...
... Diphenylyl methane Derivatives: Bisacodyl: Mechanism of Action: This agent is hydrolyzed in gut through deacetylation and converted to active form which produces low grade inflammation as a result of which motility and secretions are increased. Adverse Effects: Abdominal pain/discomfort, few allerg ...
Pre-Proposal Template
... mechanism(s). What is/are the unmet medical need(s) this target/pathway could address? Is this pathway targetable with a biotherapeutic? ...
... mechanism(s). What is/are the unmet medical need(s) this target/pathway could address? Is this pathway targetable with a biotherapeutic? ...
YAZ® and YASMIN - James A. Simon, MD
... Why are YAZ® and YASMIN® being singled out in these commercials? The most common oral contraceptive pills are combination pills, including both an estrogen component and a progestogen component. The majority of birth control pills contain the same estrogen component (ethinyl estradiol), but there ar ...
... Why are YAZ® and YASMIN® being singled out in these commercials? The most common oral contraceptive pills are combination pills, including both an estrogen component and a progestogen component. The majority of birth control pills contain the same estrogen component (ethinyl estradiol), but there ar ...
Naturally Occurring Toxins in household cleaning products:
... Toxic properties: evidence of the endocrine, reproductive and developmental system effects, increased risk of breast cancer Commercial products: Food (as a preservative up to 1%), cosmetics such as shampoos, moisturizers, shaving gels, cleansing gels, personal lubricants, topical/ parenteral pha ...
... Toxic properties: evidence of the endocrine, reproductive and developmental system effects, increased risk of breast cancer Commercial products: Food (as a preservative up to 1%), cosmetics such as shampoos, moisturizers, shaving gels, cleansing gels, personal lubricants, topical/ parenteral pha ...
Document
... travel across the cleft and attach to the postsynaptic membrane (F) at the postsynaptic receptor sites (G). 5. The neurotransmitters separate from the receptors. 6. The neurotransmitters are taken back into the presynaptic neuron, diffuse away, or are inactivated by chemicals. ...
... travel across the cleft and attach to the postsynaptic membrane (F) at the postsynaptic receptor sites (G). 5. The neurotransmitters separate from the receptors. 6. The neurotransmitters are taken back into the presynaptic neuron, diffuse away, or are inactivated by chemicals. ...
Drugs and the Synapse
... travel across the cleft and attach to the postsynaptic membrane (F) at the postsynaptic receptor sites (G). 5. The neurotransmitters separate from the receptors. 6. The neurotransmitters are taken back into the presynaptic neuron, diffuse away, or are inactivated by chemicals. ...
... travel across the cleft and attach to the postsynaptic membrane (F) at the postsynaptic receptor sites (G). 5. The neurotransmitters separate from the receptors. 6. The neurotransmitters are taken back into the presynaptic neuron, diffuse away, or are inactivated by chemicals. ...
Commercial Products
... Toxic properties: evidence of the endocrine, reproductive and developmental system effects, increased risk of breast cancer Commercial products: Food (as a preservative up to 1%), cosmetics such as shampoos, moisturizers, shaving gels, cleansing gels, personal lubricants, topical/ parenteral pha ...
... Toxic properties: evidence of the endocrine, reproductive and developmental system effects, increased risk of breast cancer Commercial products: Food (as a preservative up to 1%), cosmetics such as shampoos, moisturizers, shaving gels, cleansing gels, personal lubricants, topical/ parenteral pha ...
NOOTROPIC DRUGS
... intestine within 45 minutes of ingestion. After ingestion it is distributed throughout all tissues of the body and is eliminated by first-order kinetics. The half-life of caffeine varies widely among individuals according to such factors as age, liver function, pregnancy, some concurrent medications ...
... intestine within 45 minutes of ingestion. After ingestion it is distributed throughout all tissues of the body and is eliminated by first-order kinetics. The half-life of caffeine varies widely among individuals according to such factors as age, liver function, pregnancy, some concurrent medications ...
Presentation
... •Many pesticides known to either inhibit or induce cytochrome P-450 isoforms in animals and man • More work to characterise their potential in vivo effects at the current level of exposure using recombinant technology and toxicokinetic assays (Hodgson and Rose, 2005). ...
... •Many pesticides known to either inhibit or induce cytochrome P-450 isoforms in animals and man • More work to characterise their potential in vivo effects at the current level of exposure using recombinant technology and toxicokinetic assays (Hodgson and Rose, 2005). ...
100618-Technical
... Juvenile Idiopathic Arthritis (JIA) is an "umbrella" term which is used to cover Juvenile Rheumatoid Arthritis (JRA) and Juvenile Chronic Arthritis (JCA). Biologic agents are needed when others like NSAIDs (Non-steroidal anti-inflammatory agents), DMARDs (Disease modifying antirheumatic drugs) canno ...
... Juvenile Idiopathic Arthritis (JIA) is an "umbrella" term which is used to cover Juvenile Rheumatoid Arthritis (JRA) and Juvenile Chronic Arthritis (JCA). Biologic agents are needed when others like NSAIDs (Non-steroidal anti-inflammatory agents), DMARDs (Disease modifying antirheumatic drugs) canno ...
Habitat Asessment Factors Feb6_2015 FEMA R10 - STARR-Team
... they must be fully avoided, not just minimized or compensated for) over either short- or long-term temporal scales to. The features that must not be impaired are: 1) water quality; 2) water quantity; 3) flood volumes; 4) flood velocities; 5) spawning substrate; or 6) floodplain refugia for ESA-liste ...
... they must be fully avoided, not just minimized or compensated for) over either short- or long-term temporal scales to. The features that must not be impaired are: 1) water quality; 2) water quantity; 3) flood volumes; 4) flood velocities; 5) spawning substrate; or 6) floodplain refugia for ESA-liste ...
Pharmacology of the autonomic nervous system for dental students
... mitochondria synthetize acetyl-CoA and with choline form acetylcholine. This reaction is catalysed by cholineacetylase enzyme. Acetylcholine is stored in axonal vesicles and released by an exocytotic mechanism. This mechanism is triggered by calcium ions. In the synaptic cleft, acetylcholine binds t ...
... mitochondria synthetize acetyl-CoA and with choline form acetylcholine. This reaction is catalysed by cholineacetylase enzyme. Acetylcholine is stored in axonal vesicles and released by an exocytotic mechanism. This mechanism is triggered by calcium ions. In the synaptic cleft, acetylcholine binds t ...
Introduction to PKPD Continued, Professor Leon Aarons
... Linear and Log linear models - Caveats • The linear and log-linear models are often used as approximations for the description of concentration-effect relationships in human studies when: 1 the occurrence of side-effects prevents the administration of high doses. 2 the drug has a long half-life, re ...
... Linear and Log linear models - Caveats • The linear and log-linear models are often used as approximations for the description of concentration-effect relationships in human studies when: 1 the occurrence of side-effects prevents the administration of high doses. 2 the drug has a long half-life, re ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.