Lecture : Contents : Treatment of Urinary Tract Infection
... Mechanism of action : Inhibit protein synthesis by binding reversibly (Bacteriostatic )to 30 S subunit. (Doxycycline ) must be not given with Pharmacokinetics Given orally Absorption is 90-100%(completely absorped from GIT) BUT di & tri-valent cations ( Ca, Mg, Fe, AL) impair absorption ...
... Mechanism of action : Inhibit protein synthesis by binding reversibly (Bacteriostatic )to 30 S subunit. (Doxycycline ) must be not given with Pharmacokinetics Given orally Absorption is 90-100%(completely absorped from GIT) BUT di & tri-valent cations ( Ca, Mg, Fe, AL) impair absorption ...
DRUG ACTING ON ENDOCRINE SYSTEM Pituitary Hormones in
... in thyroid cells & increases iodine uptake & production of thyroid hormones. TSH has been used as a diagnostic tool to distinguish primary from secondary hypothyroidism. The ...
... in thyroid cells & increases iodine uptake & production of thyroid hormones. TSH has been used as a diagnostic tool to distinguish primary from secondary hypothyroidism. The ...
Nano-Medicine - cloudfront.net
... help with the delivery of drugs to the areas of the body where they are intended to reach. These nano-particles are thought to reach the intended areas with better accuracy, and perhaps reach intended areas that the drugs were not able to reach without nano-particles. In general, nano-particles are ...
... help with the delivery of drugs to the areas of the body where they are intended to reach. These nano-particles are thought to reach the intended areas with better accuracy, and perhaps reach intended areas that the drugs were not able to reach without nano-particles. In general, nano-particles are ...
Drugs affecting the respiratory system - Lectures
... Difficult to identify whether cause is viral or bacterial Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
... Difficult to identify whether cause is viral or bacterial Treatment is “empiric therapy,” treating the most likely cause Antivirals and antibiotics may be used, but a definite viral or bacterial cause may not be easily identified ...
Gaba - American College of Neuropsychopharmacology
... pharmacology studies supported this hypothesis (18, 22), it was the long-awaited cloning of the GABAB receptor (23) that established the true situation. The first receptor exists as two splice variants, and additional clones for GABAB receptor subtype genes have been isolated. Surprisingly, the GABA ...
... pharmacology studies supported this hypothesis (18, 22), it was the long-awaited cloning of the GABAB receptor (23) that established the true situation. The first receptor exists as two splice variants, and additional clones for GABAB receptor subtype genes have been isolated. Surprisingly, the GABA ...
HST-151
... molecular scale. Different nicotinic agonists bind to the receptor with different affinity, accounting for different levels of occupancy (i.e. the proportion of L2·nAChR in scheme 1) at equal agonist concentrations. The rate constants for channel opening and closing, α and ß, also depend on the part ...
... molecular scale. Different nicotinic agonists bind to the receptor with different affinity, accounting for different levels of occupancy (i.e. the proportion of L2·nAChR in scheme 1) at equal agonist concentrations. The rate constants for channel opening and closing, α and ß, also depend on the part ...
File
... peripheral tissues, its CNS effects may be due to actions at dopamine receptors. • In pituitary, some ergot alkaloids are potent dopamine-like inhibitors of prolactin secretion. • Bromocriptine and Pergolide are among the most potent of the semisynthetic derivatives at these dopamine D2 receptors an ...
... peripheral tissues, its CNS effects may be due to actions at dopamine receptors. • In pituitary, some ergot alkaloids are potent dopamine-like inhibitors of prolactin secretion. • Bromocriptine and Pergolide are among the most potent of the semisynthetic derivatives at these dopamine D2 receptors an ...
Psychoactive plants used in designer drugs as a
... Anthropological studies concerning preliterate societies have shown that psychoactive substances have been used for ages. On the individual level, they achieve emotional relief, resolve anxiety or phobia, reduce the physical symptoms, stimulate despite fatigue, or help forget daily problems. In a so ...
... Anthropological studies concerning preliterate societies have shown that psychoactive substances have been used for ages. On the individual level, they achieve emotional relief, resolve anxiety or phobia, reduce the physical symptoms, stimulate despite fatigue, or help forget daily problems. In a so ...
Clinical Pharmacology Pharmacotherapy of Hyperlipidemia
... It is the most important class since it is the most effective in reducing LDL. It decreases oxidative stress and vascular inflammation with increased stability of atherosclerotic lesions. Therefore, they are initiated immediately after acute coronary syndromes, irrespective of lipid levels. Mechanis ...
... It is the most important class since it is the most effective in reducing LDL. It decreases oxidative stress and vascular inflammation with increased stability of atherosclerotic lesions. Therefore, they are initiated immediately after acute coronary syndromes, irrespective of lipid levels. Mechanis ...
Growth Hormone Deficiency In Adults
... • It is recommended that the starting dose of GH should be 0.2 mg/day in young men, 0.3 mg/day in young women, and 0.1 mg/day in older individuals. • These doses are then titrated according to serum IGF1 concentrations and at a rate that minimizes side effects. • If side effects occur, the dose shou ...
... • It is recommended that the starting dose of GH should be 0.2 mg/day in young men, 0.3 mg/day in young women, and 0.1 mg/day in older individuals. • These doses are then titrated according to serum IGF1 concentrations and at a rate that minimizes side effects. • If side effects occur, the dose shou ...
patrick_tb_ch05
... a. It is important that the binding interactions involve a mixture of van der Waals interactions, hydrogen bonds and ionic bonds since neurotransmitters have different functional groups. b. The binding interactions must be of the correct nature to match the functional groups of the neurotransmitter ...
... a. It is important that the binding interactions involve a mixture of van der Waals interactions, hydrogen bonds and ionic bonds since neurotransmitters have different functional groups. b. The binding interactions must be of the correct nature to match the functional groups of the neurotransmitter ...
Indirect cholinomimetics-level I
... Reversible indirect cholinomimetics Short acting, reversible • Drugs as Edrophonium • Alcohol • forms weak hydrogen bond with cholinesterase Intermediate acting, reversible • Carbamates esters • binds to two sites of cholinesterase enzyme • All polar except physostigmine – Physostigmine – Pyridosti ...
... Reversible indirect cholinomimetics Short acting, reversible • Drugs as Edrophonium • Alcohol • forms weak hydrogen bond with cholinesterase Intermediate acting, reversible • Carbamates esters • binds to two sites of cholinesterase enzyme • All polar except physostigmine – Physostigmine – Pyridosti ...
Hormone Products and Prescription
... uteri. The use of CHT reduces the risk of endometrial hyperplasia that occurs with unopposed estrogen use, but other risk-benefit comparisons-for osteoporosis, breast cancer, and cardiovascular disease-are less conclusive and more controversial. The use of CHT was the subject of an FDA advisory comm ...
... uteri. The use of CHT reduces the risk of endometrial hyperplasia that occurs with unopposed estrogen use, but other risk-benefit comparisons-for osteoporosis, breast cancer, and cardiovascular disease-are less conclusive and more controversial. The use of CHT was the subject of an FDA advisory comm ...
The Debate - HysterSisters
... you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart ...
... you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chances of getting heart ...
Systemic meds and ocular side effects revised
... Antimalarials Aralen phosphate (chloroquine) • Obtain tests as plaquenil exam. • See patients at least annually if dosage is less than 3.0 mg/kg of ideal body weight. • See every 6 months if dosage is greater than 3.0 mg/kg body weight, or if patients are short, obese, or have renal and/or liver im ...
... Antimalarials Aralen phosphate (chloroquine) • Obtain tests as plaquenil exam. • See patients at least annually if dosage is less than 3.0 mg/kg of ideal body weight. • See every 6 months if dosage is greater than 3.0 mg/kg body weight, or if patients are short, obese, or have renal and/or liver im ...
Pain control in cancer: recent findings and trends
... The sympathetic nervous system is also important in neuropathic pain since sympathectomy induces pain relief. Sympathetically maintained pain may be due to sprouting of sympathetic neurons into dorsal root ganglia of injured sensory neurons and post-injury sprouting of sympathetic fibres into the de ...
... The sympathetic nervous system is also important in neuropathic pain since sympathectomy induces pain relief. Sympathetically maintained pain may be due to sprouting of sympathetic neurons into dorsal root ganglia of injured sensory neurons and post-injury sprouting of sympathetic fibres into the de ...
Damaging effects of water-borne cadmium chloride on
... Route of exposure is an important determinant of the genotoxicity of a chemical owing to its mode of action (Sekihashi et al., 2002). The amount of cadmium absorbed by the body depends on the route of entry. Approximately 5-6% of a given dosage of cadmium is absorbed from the gastrointestinal tract, ...
... Route of exposure is an important determinant of the genotoxicity of a chemical owing to its mode of action (Sekihashi et al., 2002). The amount of cadmium absorbed by the body depends on the route of entry. Approximately 5-6% of a given dosage of cadmium is absorbed from the gastrointestinal tract, ...
Hepatoprotective potential of Cordia subcordata Lam. against
... ALT, ALP and ACP has been attributed to the damaged structural integrity of the liver, because they are cytoplasmic in location and released into circulation after cellular damages [26]. In our study, the biochemical changes were observed after each 3 and 7 days. Thereby, it was found that, the admi ...
... ALT, ALP and ACP has been attributed to the damaged structural integrity of the liver, because they are cytoplasmic in location and released into circulation after cellular damages [26]. In our study, the biochemical changes were observed after each 3 and 7 days. Thereby, it was found that, the admi ...
Design and Development of Superoxide Dismutase Mimetics as
... SAR studies utilizing the [Mn([15]aneN5)Cl2] lead reveals that extremely high chemical stability is achieved with added substituents to carbon centers of the macrocyclic ligand (Inorg.Chem.,35, 5213, ...
... SAR studies utilizing the [Mn([15]aneN5)Cl2] lead reveals that extremely high chemical stability is achieved with added substituents to carbon centers of the macrocyclic ligand (Inorg.Chem.,35, 5213, ...
ORAL ACUTE AND SUB ACUTE TOXICITY STUDIES OF TWO SIDDHA... VEDIKARA SILASATHU PARPAM (VSP) AND NERUNJIL KUDINEER (NK) IN EXPERIMENTAL
... The biological activity of the drug and its mechanism of action are obtained by conducting acute toxicity testing. Acute toxicity test is used in hazard identification and risk management of the drug. In this study, the acute and sub acute toxicity of Vedikara silasathu parpam(VSP) and Nerunjil kudi ...
... The biological activity of the drug and its mechanism of action are obtained by conducting acute toxicity testing. Acute toxicity test is used in hazard identification and risk management of the drug. In this study, the acute and sub acute toxicity of Vedikara silasathu parpam(VSP) and Nerunjil kudi ...
Methylphenidate - Addiction Science Network
... • Highest uptake of MPH occurred in basal ganglia • Temporal patterns of MPH different from Cocaine ...
... • Highest uptake of MPH occurred in basal ganglia • Temporal patterns of MPH different from Cocaine ...
phera-plex - AnabolicMinds.com
... stated, there is a chance of very mild indirect aromatisation with 2-ene™ (from a metabolite, as it cannot aromatise directly itself), and thus the chances of developing gyno are certainly there, but for the most part this effect is highly unlikely, unless stacking with other aromatising compounds t ...
... stated, there is a chance of very mild indirect aromatisation with 2-ene™ (from a metabolite, as it cannot aromatise directly itself), and thus the chances of developing gyno are certainly there, but for the most part this effect is highly unlikely, unless stacking with other aromatising compounds t ...
PDF of this article
... plants, although forest fires and unprocessed fossil fuels, such as coal and oil, can be important sources as well. PAHs readily attach to sediment particles, leading to elevated concentrations in sediments. Due to their hexagonal ring-structure, PAHs are very stable compounds that can persist in th ...
... plants, although forest fires and unprocessed fossil fuels, such as coal and oil, can be important sources as well. PAHs readily attach to sediment particles, leading to elevated concentrations in sediments. Due to their hexagonal ring-structure, PAHs are very stable compounds that can persist in th ...
Acetic anhydride Product Number A6404 Store at - Sigma
... 10. Belosludtsev, Y., et al., DNA microarrays based on noncovalent oligonucleotide attachment and hybridization in two dimensions. Anal. Biochem., ...
... 10. Belosludtsev, Y., et al., DNA microarrays based on noncovalent oligonucleotide attachment and hybridization in two dimensions. Anal. Biochem., ...
Toxicodynamics
Toxicodynamics, termed pharmacodynamics in pharmacology, describes the dynamic interactions of a toxicant with a biological target and its biological effects. A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other receptors. When a toxicant enters an organism, it can interact with these receptors and produce structural or functional alterations. The mechanism of action of the toxicant, as determined by a toxicant’s chemical properties, will determine what receptors are targeted and the overall toxic effect at the cellular level and organismal level.Toxicants have been grouped together according to their chemical properties by way of quantitative structure-activity relationships (QSARs), which allows prediction of toxic action based on these properties. endocrine disrupting chemicals (EDCs) and carcinogens are examples of classes of toxicants that can act as QSARs. EDCs mimic or block transcriptional activation normally caused by natural steroid hormones. These types of chemicals can act on androgen receptors, estrogen receptors and thyroid hormone receptors. This mechanism can include such toxicants as dichlorodiphenyltrichloroethane (DDE) and polychlorinated biphenyls (PCBs). Another class of chemicals, carcinogens, are substances that cause cancer and can be classified as genotoxic or nongenotoxic carcinogens. These categories include toxicants such as polycyclic aromatic hydrocarbon (PAHs) and carbon tetrachloride (CCl4). The process of toxicodynamics can be useful for application in environmental risk assessment by implementing toxicokinetic-toxicodynamic (TKTD) models. TKTD models include phenomenas such as time-varying exposure, carry-over toxicity, organism recovery time, effects of mixtures, and extrapolation to untested chemicals and species. Due to their advantages, these types of models may be more applicable for risk assessment than traditional modeling approaches.