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Use of Tissue Culture—Amplified Human Immunodeficiency Virus
Use of Tissue Culture—Amplified Human Immunodeficiency Virus

... [3, 4]. Proviral DNA from PBMC represent HIV-1 variants integrated at unknown times in the past; for some proviruses, this integration might have occurred as early as the acute infection stage [6–8]. Plasma viral RNA load decreases within hours of initiating antiviral therapies and is the first vira ...
Prevention and management of neonatal herpes simplex virus
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... In most cases, the initial symptoms of NHSV infection present within the first four weeks of life. Occasionally, disease presents for the first time between four and six weeks after birth;[4] therefore, infants up to 42 days of age should be fully evaluated for NHSV when clinical features are consis ...
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... United States,” Garmendia remarks. Once an infectious disease becomes established, natural selection takes over as some resistant animals survive. These carriers become persistently infected, spreading the disease rather than immediately succumbing to it. Says Garmendia, “During the normal virus cyc ...
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... The manipulation and production of this non-replicative lentiviral vector expressing gene products that are not intrinsically harmful or do not induce hazardous properties in the transduced cells require a Biosafety Level 2 (BSL-2). Any manipulation involving cell cultures and recombinant viral vect ...
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Herpes simplex virus



Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the herpesvirus family, Herpesviridae, that infect humans. Both HSV-1 (which produces most cold sores) and HSV-2 (which produces most genital herpes) are ubiquitous and contagious. They can be spread when an infected person is producing and shedding the virus. Herpes simplex can be spread through contact with saliva, such as sharing drinks.Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. Lesions heal with a scab characteristic of herpetic disease. Sometimes, the viruses cause very mild or atypical symptoms during outbreaks. However, as neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons. After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks. In an outbreak, the virus in a nerve cell becomes active and is transported via the neuron's axon to the skin, where virus replication and shedding occur and cause new sores. It is one of the most common sexually transmitted infections.
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