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Keeping 53BP1 out of focus in mitosis
Keeping 53BP1 out of focus in mitosis

... promoting recruitment of downstream factors necessary for DNA repair, such as the RAP80-Abraxas-BRCA1 complex and 53BP1 [3]. Significantly, the full DDR happens only in interphase cells, whereas if mitotic cells sustain DSBs, the process appears to be blocked at the stage of RNF8 recruitment, result ...
CHAPTER 1 Genetics: An Introduction
CHAPTER 1 Genetics: An Introduction

... when a mother cell produces two genetically identical daughter cells. For example: If the mother cell has 46 chromosomes the daughter cells will also have 46 chromosomes. • Cell division has two steps: Mitosis or division of the nucleus and cytokinesis or division of the cytoplasm. • Mitosis has fou ...
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cells - (www.ramsey.k12.nj.us).

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Structure and Function of Cells

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Mitosis



Mitosis is a part of the cell cycle in which chromosomes in a cell nucleus are separated into two identical sets of chromosomes, each in its own nucleus. In general, mitosis (division of the nucleus) is often followed by cytokinesis, which divides the cytoplasm, organelles and cell membrane into two new cells containing roughly equal shares of these cellular components. Mitosis and cytokinesis together define the mitotic (M) phase of an animal cell cycle—the division of the mother cell into two daughter cells, genetically identical to each other and to their parent cell.The process of mitosis is divided into stages corresponding to the completion of one set of activities and the start of the next. These stages are prophase, prometaphase, metaphase, anaphase, and telophase. During mitosis, the chromosomes, which have already duplicated, condense and attach to fibers that pull one copy of each chromosome to opposite sides of the cell. The result is two genetically identical daughter nuclei. The cell may then divide by cytokinesis to produce two daughter cells. Producing three or more daughter cells instead of normal two is a mitotic error called tripolar mitosis or multipolar mitosis (direct cell triplication / multiplication). Other errors during mitosis can induce apoptosis (programmed cell death) or cause mutations. Certain types of cancer can arise from such mutations.Mitosis occurs only in eukaryotic cells and the process varies in different organisms. For example, animals undergo an ""open"" mitosis, where the nuclear envelope breaks down before the chromosomes separate, while fungi undergo a ""closed"" mitosis, where chromosomes divide within an intact cell nucleus. Furthermore, most animal cells undergo a shape change, known as mitotic cell rounding, to adopt a near spherical morphology at the start of mitosis. Prokaryotic cells, which lack a nucleus, divide by a different process called binary fission.
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