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Profile Documents Logout
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Powerpoint
Powerpoint

... • TPK portion of tree shows high degree of agreement with Manning tree • Branching is supported by species representation of kinase families ...
File
File

... • ***ONLY FUNCTIONS IN SEXUAL REPRODUCTION • ***ENSURES GENETIC DIVERSITY ...
Lecture 10 - Genetics & Ethics
Lecture 10 - Genetics & Ethics

... on chromosome 4  Since the early 90’s a very reliable genetic test for such an enlargement has existed  Even if you presently show no signs of Huntington’s, it can tell you with great reliability whether you carry a gene that makes it extraordinarily likely that you will ...
statgen3
statgen3

... these examples of natural selection certain phenotypes are better able than others to contribute their genes to the next generation. Thus, by Darwin's standards, they are more fit. The outcome is a gradual change in the gene frequencies in that population. ...
Technician Education Session for MedRec
Technician Education Session for MedRec

... 3. Ask if patient has prescription vials or a list of their medication with them. 4. Ask patient to describe how much and how often they are taking each medication, for when needed (PRN) medications ask if they are taking it regularly or only once in a while (ask when last dose was taken). For each ...
respiratory depression due to clonazepam and fluconazole
respiratory depression due to clonazepam and fluconazole

... enzymes involved in the drug metabolism. CYP3A4 is involved in the oxidation of the largest range of substrates of all the CYPs. As a result, CYP3A4 is present in the largest quantity of all the CYPs in the liver.[2]Clonazepam is a benzodiazepine drug having anxiolytic, anticonvulsant, muscle relaxa ...
Tofranil™ imipramine hydrochloride tablets USP (10 mg, 25 mg, and
Tofranil™ imipramine hydrochloride tablets USP (10 mg, 25 mg, and

... activity among Asian, African, and other populations are not yet available. Poor metabolizers have higher than expected plasma concentrations of tricyclic antidepressants (TCAs) when given usual doses. Depending on the fraction of drug metabolized by P450 2D6, the increase in plasma concentration ma ...
Introduction to Anti-Fungals
Introduction to Anti-Fungals

... - Unlike ketoconazole and itraconazole, fluconazole has high bioavailability and has the least effects of all azoles on cytochrome P450 enzymes - It is the agent most used in treatment of mucocutaneous candidiasis. Voriconazole: - new, good absorption, high bioavailability and less plasma protein bi ...
Quiz 1 Key - chem.uwec.edu
Quiz 1 Key - chem.uwec.edu

... 1. On a single graph, draw a typical dose/response curve for the new natural product drug, hartseloic acid. Also draw dose/response curve for the drug in the presence of (A) , a competitive antagonist and (B) a non-competitive antagonist. In addition, include a curve for a newly discovered similar d ...
The Language of Heredity
The Language of Heredity

... By contrast, the genes that control the development of eyefolds are part of your genotype. Genotype is the name for the genes an organism has. Your genotype is not always obvious from your phenotype. If you have eyefolds, your genotype definitely contains at least one eyefold-producing allele. But i ...
Adverse reactions to drugs, BMJ 1998
Adverse reactions to drugs, BMJ 1998

... Adverse drug reactions are a major clinical problem, accounting for 2-6% of all hospital admissions (box).3-6 Recent surveys in the United States have indicated that adverse drug events increase the length of hospital stay and costs. 5 6 Types of adverse drug reactions Adverse drug reactions are ty ...
Addiction and Attachment Theory
Addiction and Attachment Theory

...  FMRI’s of the Brain of patients experiencing pain compared with patients experiencing rejection/loss (Eisenberger and Lieberman, 2003)  Depression and isolation increase Mu activity ...
Psychoactive
Psychoactive

... tension than against it…there does not seem to be a preponderance of evidence that would indicate the abolition of the use of tobacco as a substance contrary to the public health” ...
objectives - NC State Veterinary Medicine
objectives - NC State Veterinary Medicine

... Martignoni, M, G M. Groothuis, and R De Kanter. "Species Differences Between Mouse, Rat, Dog, Monkey and Human CYP-mediated Drug Metabolism, Inhibition and Induction." Expert Opinion on Drug Metabolism and Toxicology 2.6 (2006): 875-894. Print Coelho, J. C., Tucker, R., Mattoon, J., Roberts, G., Wai ...
Patient Education DISULFIRAM
Patient Education DISULFIRAM

... (palpitations), blurred vision or weakness when even small amounts of alcohol are ingested. These disulfiram-alcohol reactions can occur up to two weeks after the medication has been stopped. Because disulfiram can cause drowsiness, use caution when driving or engaging in activities requiring alert ...
Slide 1
Slide 1

... Clozapine, olanzapine and risperidone were better than firstgeneration drugs for overall efficacy, with small to medium effect sizes Other second generation drugs were NOT more efficacious, even for negative symptoms Second-generation drugs induced fewer EPSE than haloperidol, but only a few have fe ...
name period
name period

... B. Shows all possible genetic combinations between two parents C. The allele that does not show in a heterozygous ...
Secondary Stroke Prevention: Implications of the MATCH Trial
Secondary Stroke Prevention: Implications of the MATCH Trial

... * AJP, August 2004, pg 1334. (These are recs for patients with schizophrenia) ...
Question - MCE Conferences
Question - MCE Conferences

...  Most patients with Stage 1 will experience better BP control & lower CVD risk when taking a thiazide-type diuretic  Most patients with Stage 2 disease will experience better BP control & lower CVD risk when taking a multidrug regimen that includes a thiazide-type diuretic ...
lecture7
lecture7

... Unit of Study In Population Genetics ” A population in the genetic sense, is not just a group of individuals but a breeding group; and the genetics of a population is concerned not only with the genetic constitution of the individuals but also with the transmission of the genes from one generation t ...
Slide Deck
Slide Deck

... [email protected] ...
Withdrawal from benzodiazepine dependence
Withdrawal from benzodiazepine dependence

... Consider contacting the HIC about the patients past pattern of drug use and doctor attendance Consider developing a contract of behaviour in which consequences for non-compliance are clearly spelt out. Notify the DPU Switch to a single long acting BZD, usually diazepam. Dose equivalents are unreliab ...
Etopan 400, 500, 600 mg XL Tablets
Etopan 400, 500, 600 mg XL Tablets

... are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics, and the elderly. Discontinuation of NSAIDs therapy is usually followed by recovery to the pretreatment state. Etodolac metabolites are eliminated primarily by the kidneys. The extent to which the inacti ...
Pathway to Patients
Pathway to Patients

... TB Alliance ...
ZAROXOLYN 5mg tablets ZAROXOLYN 10 mg tablets Metolazone
ZAROXOLYN 5mg tablets ZAROXOLYN 10 mg tablets Metolazone

... tablet) or 5 mg a day, in the morning. Heart failure-related oedema: 5-10 mg once a day, in the morning. Renal failure-related oedema: 5-20 mg once a day, in the morning. After having obtained the desired therapeutic effect, it is usually appropriate to reduce the dose of Zaroxolyn to lower, mainten ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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