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shands - UF Health Professionals
shands - UF Health Professionals

... published data to support increased efficacy. There are few data that suggest better safety, but these are based on surrogate markers. There are no documented differences in adverse outcomes between hetastarch in LR compared to hetastarch in NS. In the Hextend® labeling it states that there are no s ...
Classification Scheme for Illicit Drugs
Classification Scheme for Illicit Drugs

... Physicians’ Desk Reference PDR—A Physicians’ Desk Reference is used to identify manufactured pills, tablets, and capsules. It is updated each year. This can sometimes be a quick and easy identifier of the legally made drugs that may be found at a scene. The reference book gives a picture of the drug ...
Chapter 14
Chapter 14

Mendel`s Theory
Mendel`s Theory

... When two different alleles occur together, one of them may be completely expressed, while the other may have no observable effect on the organism’s appearance.  Dominant  Recessive ...
Warfarin – indications, risks and drug interactions
Warfarin – indications, risks and drug interactions

... five times more potent than the R isomer. It is important to realise that those two isomers are metabolised via two different pathways and that drug interactions affecting the S isomer are more important clinically because of its high potency. The S isomer is metabolised via the cytochrome P450 (CYP ...
Cholinoceptor blocking drugs
Cholinoceptor blocking drugs

... sweating increased tone and motility increased tone, effect variable, low doses decrease HR; higher could increase HR and BP. fasciculations and tremor; paralysis ...
February 19, 2013 Drug Enforcement Administration Attention: DEA
February 19, 2013 Drug Enforcement Administration Attention: DEA

... substances. Hospices work with these survivors around the many tasks that must be completed in the home after the death of a patient, including instruction on the proper disposal of unused medications. 4. Wider availability of mail back programs could be very useful, and hospices could play a role i ...
Reporting Adverse Events and Market Research AE Reporting by
Reporting Adverse Events and Market Research AE Reporting by

... Adverse Event •In spirit of ‘risk-sharing’ some pharmaceutical companies (based on legal and regulatory staff advice) want reports from market research on anything that might even be construed as an adverse event •“Untoward medical occurrence in a patient administered a pharmaceutical product that d ...
ORAL GLAUCOMA AGENT?
ORAL GLAUCOMA AGENT?

... •Diflucan may be prescribed but do it through OB GYN • Stop antibiotic if patient reports severe diarrhea/blood in stool ...
summary of product characteristics 1. name of the medicinal
summary of product characteristics 1. name of the medicinal

... Interaction with other medicinal products and other forms of interaction Due to atenolol: Concurrent use of alcohol may increase the hypotensive effects of beta-adrenoceptor blocking agents. As with all beta-adrenoceptor blocking agents, when used concurrently with insulin and oral antidiabetic drug ...
Buccal Midazolam
Buccal Midazolam

... For children, do NOT give a second dose unless this has been previously agreed with the consultant and parent/carer. If the child re-fits an ambulance should be called. Ambulance staff may repeat the dose if deemed appropriate. What to do if a seizure starts again The official guidance states that n ...
Quantitative Traits
Quantitative Traits

DAY 2: Mechanisms of evolution
DAY 2: Mechanisms of evolution

... • Microevolution occurs when the relative frequency of alleles changes over a number of generations • For many genes, there are 2 or more alleles in gene pool • Can you imagine a scenario in which an environmental “pressure” could change allele frequencies in a population? • There is variation among ...
Quick Unit Summary A gene is a stretch of DNA that codes for a
Quick Unit Summary A gene is a stretch of DNA that codes for a

... A gene is a stretch of DNA that codes for a specific characteristic or physical trait. Organisms always have 2 copies of each gene- the one they inherited from their biological mother and the one they inherited from their biological father. Genes have varying levels of expression, referred to as dom ...
Heredity and Environment
Heredity and Environment

... code, completed in 2001. This map has revealed that all living creatures share genes; that the more closely related the organisms, the more genes they share; and that humans have only between 18,000 and 23,000 genes. The regulator genes and the “junk” around the genes are responsible for differences ...
Blister Packaging of Oral Solids - Challenges for the Pharma
Blister Packaging of Oral Solids - Challenges for the Pharma

... A high percentage of prescribed drug therapies do not achieve optimum outcomes for simple reasons like patient forgetfulness. To compensate, pharmaceutical companies are looking to maximise the benefits of oral therapies to better match users’ lifestyles. In addition, there is a high likelihood that ...
Antimicrobial1
Antimicrobial1

... reserved for life-threatening infections because of the drug's potential for serious toxicity to the patient. Note: safety is related not only to the inherent nature of the drug but also to patient factors that can predispose to toxicity ...
Medication Use
Medication Use

... action of fat-soluble drugs (increased half-life) • Lower level of serum proteins (eg, albumin) increases the concentration of the unbound (free or active) form of drugs ...
METHODS Subjects Thirty-two healthy male volunteers were
METHODS Subjects Thirty-two healthy male volunteers were

... participants) and opiates (one participant, three others had used prescribed morphine). None of the participants reported prior drug dependence or addiction, and none had taken morphine in any form for at least two years prior to testing3. All participants had normal or corrected-to-normal vision. G ...
Genetic-Explanantion..
Genetic-Explanantion..

... molecular genetics is not innocent in itself, however people who inherit a number of them are at high risk of developing Schizophrenia. ...
drugs
drugs

Pregnancy Recovery Center Magee
Pregnancy Recovery Center Magee

... Buprenorphine dosing schedule should be stopped following a cesarean section Patients should be given IV Toradol for the first 24 hours In unique circumstances, IV acetaminophen or a PCA w/ a full opioid agonist (i.e. fentanyl, morphine) can be added for additional pain management. Following the fir ...
poster in ppt
poster in ppt

... can be a meaningful part of the solution and the translation process is easier. multi genome: each individual of the population is represented by a chromosome that could be composed by a variable number of genomes. Each genome of a chromosome represent a "substrategy" and the chromosome is the genet ...
Tales of Bath Salts and Legal Marijuana: TheRapidExpansion
Tales of Bath Salts and Legal Marijuana: TheRapidExpansion

... dopamine, serotonin in the body and brain.  Severe delirium and agitation ...
Improving Healthcare with Analytics
Improving Healthcare with Analytics

... doesn't work for half the patients  Just don't know which half – like Wanamaker  Data science promise is that if we can collect enough treatment data and use it effectively  We'll be able to develop predictive models that will tell us which treatment will be more effective for which patient ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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