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ppt
ppt

... Tens of thousands of human genomes have now been sequenced at low depth Can detect most polymorphisms with frequency >0.01 True whole genome association studies now possible at a very large scale Direct to Consumer Genomics: 23 & Me and other genotyping services http://www.1000genomes.org/ ...
Q17 Classify the calcium channel blockers and
Q17 Classify the calcium channel blockers and

... Binds  to  the  N  binding  site  of  the  L-­‐type   Binds  to  the  V  binding  site  of  the  L  type   calcium  channels  on  vascular  smooth   calcium  channel.  Reduces  conduction  in  atrial,   muscle  to  reduce  intracellul ...
Federal Register/Vol. 77, No. 49/Tuesday, March 13, 2012/Notices
Federal Register/Vol. 77, No. 49/Tuesday, March 13, 2012/Notices

... for the other DURANEST drug products listed in the table in this document, those drug products have also been discontinued. On our own initiative, we have also determined whether those products were withdrawn for safety or effectiveness reasons. After considering the citizen petition and reviewing A ...
nephr%gy
nephr%gy

... and codeine for many reasons, even if another pathogenetic mechanism cannot be ruled out. First of all, there was a close temporal relationship between drug ingestion and onset of symptoms. Moreover, co-efferalgan (acetaminophen and codeine) was the only drug added before the onset of cutaneous, ren ...
Opioid consumers: from the Pain Clinic to the
Opioid consumers: from the Pain Clinic to the

... 1Hospital Clínic Universitari Barcelonaa Psychiatrya Barcelonaa Spain 2Hospital Clínic Universitari Barcelonaa Psychologya Barcelonaa Spain 3Hospital Clínic Universitari Barcelonaa Anaesthesiologya Barcelonaa Spain Purpose of the study: Chronic pain is a prevalent condition worldwide. Suffering it, ...
PPT
PPT

... • 200mg/d of a standardized extract of the root containing 4-7% ginsenosides; it is recommended to take for 4 weeks then stop for 1-2 weeks. •Adverse Effects •much listed but close evaluation indicates wide safety; reports of problems may be associated with poor products and adulterated products •Dr ...
The “Magic Bullet” idea
The “Magic Bullet” idea

... – Consent needed for use of PHI. Standard consents ...
Pharma (med)
Pharma (med)

... for a long time. Suddenly he stopped taking this preparation. After this his condition grew worse, this led to development of hypertensive crisis. This by-effect can be classified as: A Abstinence syndrome B Cumulation C Tolerance D Sensibilization E Dependence ...
Review Slides
Review Slides

... http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3471.html ...
Cytotec - DavisPlus
Cytotec - DavisPlus

Perjeta,	an	Antibody For	Metastatic	Breast	Cancer NEW	DRUGS
Perjeta, an Antibody For Metastatic Breast Cancer NEW DRUGS

... opioid dose without changes and used their breakthrough opioid analgesic as needed. On each day, they rated their pain, sleep, use of other drugs, and quality of life, including constipation, daily functioning, and well-being. The study’s primary endpoint (a 30% response) was not significant for nab ...
Agenda 06/12/06 1. Notes - Genetics 2. Practice Problems 3
Agenda 06/12/06 1. Notes - Genetics 2. Practice Problems 3

... • Recessive Gene does not show its trait when there is a dominant gene. • These are written with lowercase letters. a, b, c ...
Ch 9.3 SR
Ch 9.3 SR

... codominance incomplete dominance traits allele a. __________ are segments of DNA that carry hereditary instructions and are found on chromosomes. b. Different forms of a single gene are called __________. c. __________ is when a recessive and a dominant trait mix or blend. d. In horses, when a pure ...
When Parents are Related
When Parents are Related

Nursing pharmacology Drugs Affecting Cardiovascular
Nursing pharmacology Drugs Affecting Cardiovascular

... • A 45-year-old man has recently been diagnosed with hypertension and started on monotherapy designed to reduce peripheral resistance and prevent NaCl and water retention. He has developed a persistent cough. • Which of the following drugs would have the same benefits but would not cause cough? • A ...
the side effects of common psychiAtric drugs internAtionAl
the side effects of common psychiAtric drugs internAtionAl

... WARNINGS AND STUDIES ON SPECIFIC PSYCHOSTIMULANTS: ADDERALL (amphetamine and dextroamphetamine): Adderall is an amphetamine mixture that has been linked to violent behavior when, in 1999, a North Dakota judge acquitted 24-year-old Ray Ehlis of murdering his 5-week-old daughter after two independent ...
Prebiotics in acute diarrhoea in children
Prebiotics in acute diarrhoea in children

... -Living micro-organisms that, upon ingestion in certain numbers, exert health benefiting effects beyond inherent general nutrition -The most commonly used probiotics are lactic acid bacteria such as bifidus or lactobacilla -Probiotics are believed to improve the immune response in allergic or infect ...
Introduction to Pharmacology
Introduction to Pharmacology

... between the rise in plasma concentrations and the time needed for the drug to distribute to the site of action • Other drug effects require changes in gene expression and protein synthesis to occur before becoming manifest • Another example is the effects of warfarin on blood clotting-decreased synt ...
The Genetics of Pain
The Genetics of Pain

... • All 4 cytokines harbour functional polymorphisms that alter their activity ...
Mechanisms of Non Mechanisms of Non
Mechanisms of Non Mechanisms of Non

... of cards occurred by random sampling, not by any process of selection. An analogous process involving the chance loss of alleles occurs during reproduction. ...
Productivity Shortfalls in Drug Discovery: Contributions from the
Productivity Shortfalls in Drug Discovery: Contributions from the

... cancer and Parkinson’s disease (Marino et al., 2008). This is truly an example of reductionism being “humbled by nature’s complexity” (Kenakin, 2009). Similarly, the relationship between identified genetic variants and disease causality—and by definition mechanisms of drug action— has been equally p ...
Pharmcokinetics in Critical Care
Pharmcokinetics in Critical Care

... following her 3rd dose of metoprolol, LR converts back to sinus rhythm after her next dose, she starts to develop bradycardia with a HR of 45-49 metoprolol is held & amiodarone is converted to oral pt maintains sinus rhythm in the 60s-70s ...
Disciplinary Committee Inquiry for Dr Tang Yen Ho Andrew
Disciplinary Committee Inquiry for Dr Tang Yen Ho Andrew

... stated that he knew the 17 patients well. They were all ‘functioning members of society’. By this he meant that they all worked at one or two jobs (he had asked for their CPF statements or other proof) and were not drug addicts or abusers of the prescribed medications. His patients had a variety of ...
shands - UF Health Professionals
shands - UF Health Professionals

... published data to support increased efficacy. There are few data that suggest better safety, but these are based on surrogate markers. There are no documented differences in adverse outcomes between hetastarch in LR compared to hetastarch in NS. In the Hextend® labeling it states that there are no s ...
Chapter 14
Chapter 14

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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