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A1990DN22700002
A1990DN22700002

... mew’s Hospital, where he immediately coordinated an extensive study of the Hi’s association and of islet-cell antibodies in families with Type I diabetes. His untimely death represented a great loss to this area of clinical research. April 2, 1990 Following these early reports, the affected sibling ...
Honors Biology Semester 2 Final Exam Review
Honors Biology Semester 2 Final Exam Review

... 2. You have sampled a population in which you know that the percentage of the homozygous recessive genotype (aa) is 36%. Using that 36%, calculate the following: a. The frequency of the "aa" genotype. b. The frequency of the "a" allele. c. The frequency of the "A" allele. d. The frequencies of the g ...
DIR 146 - Summary of Risk Assessment and Risk Management Plan
DIR 146 - Summary of Risk Assessment and Risk Management Plan

... The risk assessment concludes that risks to the health and safety of people, or the environment, from the proposed release are negligible. The risk assessment process considers how the genetic modification and proposed activities conducted with the GMOs might lead to harm to people or the environmen ...
Safety of ophthalmic drug therapy: focus on adverse efiects
Safety of ophthalmic drug therapy: focus on adverse efiects

... In spite of high quality requirements concerning ophthalmic preparations (sterility, isotonicity, a pH close to the lacrimal fluid, lack of insoluble contaminations) they are not devoid of side effects. Their application to the conjunctival sac, onto the surface of the eye or under the eyelid may ca ...
4th Kitasato-Harvard Symposium: Summary and Conclusions
4th Kitasato-Harvard Symposium: Summary and Conclusions

... multinational studies and bridging studies • Increased experience with bridging studies will likely reduce the need for these (Bob O’Neill) • Use of surrogate endpoints for bridging very attractive; use depends on acceptance of the surrogate by the scientific community. Examples: – Many vaccines: im ...
CAM and Cancer - Iowa Cancer Consortium
CAM and Cancer - Iowa Cancer Consortium

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Elite Athletes: Are the Genes the Champions?
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... Such optimal genetic profile was obtained from the theoretically best accumulated combination of 23 polymorphisms associated with endurance performance. These 23 polymorphisms, which included both the ACE I/D and ACTN3 R577X variants, were chosen based on published association studies. The polygenic ...
News New Mexico Board of Pharmacy
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Stop Drugging Our Elders!
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Topic 16.2: Inheritance
Topic 16.2: Inheritance

... Monohybrid inheritance Cross between organisms which show variation of only one characteristic Example a black animal is crossed with a white one, if all the offspring is black, the allele for black is said to be dominant and it is represented by a capital letter B while the allele for white is rec ...
I. The direct-acting drugs
I. The direct-acting drugs

... 40mg– fatal dose Acute toxic effects: 1.convulsion, coma, respiratory arrest 2.hypertention/ cardiac arrhythmias ...
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... A patient calls you at the office to report that he is out of refills for his medication. He asks you to call in the prescription refills to his pharmacist. When you ask him to make an appointment with the physician first, the patient says he does not have time. How would you handle this situation? ...
The Use of Single Pill Combination Treatments in Patients
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... In 2004, the British Hypertension Society (BHS) guidelines stated that “when no disadvantages of cost exist, fixed-drug combinations are recommended” (1). More recently, the 2006 & 2011 NICE guidelines (2,3) produced in collaboration with the BHS did not discuss the use of fixed-drug combinations (F ...
FDA Investigation into Direct to Consumer Genetic Testing
FDA Investigation into Direct to Consumer Genetic Testing

... Gutierrez has said that less risky genetic tests will likely not require PMA’s, or perhaps even 510(k) filings. Gutierrez told USA Today that a genetic test for baldness, for example, would be categorized by the FDA as a Class I device, along with tongue depressors and elastic bandages, which requir ...
Building a better drug
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... January 2012-- Chemist Caren Meyers has a calm and even-keeled demeanor. But when she starts to describe her research, this unassuming scientist begins to sound like a commander plotting an invasion. “We focus on getting compounds into cells that normally don’t penetrate soft tissues,” says Meyers, ...
Click here to input contact information. Click here to enter a date
Click here to input contact information. Click here to enter a date

...  ID and HIV specialists conduct HCV-related clinical and basic research, and many acquired experience prescribing the new HCV medications to their patients enrolled in clinical trials that generated the evidence base for FDA approval.  ID and HIV specialists are intimately familiar with the mechan ...
Chapter 20 - Back in the Game Chiropractic Wellness
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... techniques. These techniques restore movement, balance and quality of life. At Back in the Game, we go a step further and instruct people how to keep their bodies stronger and healthier. We do this by teaching proper body mechanics and developing personalized exercises that will help prevent reinjur ...
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... • Imipramine was, in the late 1950s, the first tricyclic antidepressant to be developed (by Ciba-Geigy). Initially, it was tried against psychotic disorders (e.g. schizophrenia), but proved insufficient. • During the clinical studies its antidepressant qualities, unsurpassed until the advent of SSRI ...
Single Genes With Multiple Alleles The Sex Chromosomes Traits
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... Sex-linked genes are on X and Y chromosomes because alleles are passed from parent to child on sex chromosomes Traits controlled by sex-linked genes are called sex-linked traits Most of the genes on the X chromosomes are not on the Y chromosome; therefore not all genders have the same traits ...
Genotyping Questionnaire This is the Eunefron Questionnaire for the
Genotyping Questionnaire This is the Eunefron Questionnaire for the

... You can send a blood sample (2 x 5 ml in two different tubes on EDTA for adults, 2 x 2 ml for children, 1 x 0.5 ml for newborns) of your patient and the family members for DNA analysis to the laboratory address indicated below. Shipping can be performed at room temperature, but should be done by Fed ...
drug elimination ii
drug elimination ii

... and excretion of drugs • Anatomically, the intra hepatic bile ducts join outside the liver to form the common hepatic duct. The bile that enters the gall bladder becomes highly concentrated • The hepatic duct, containing hepatic bile, join the cystic duct that drains the gallbladders to form the com ...
Monitoring Patients - Curry International Tuberculosis Center
Monitoring Patients - Curry International Tuberculosis Center

... Ideally, all TB treatment should be given by DOT, which includes watching patients swallow their medications. Treatment for multidrug-resistant TB (MDR-TB) should always be given by DOT (including pyridoxine supplementation). Weekend doses, drugs given more than once a day, and drugs tolerated only ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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