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Full Product Information
Full Product Information

... There is no information on the effects of salbutamol on human fertility. There were no adverse effects on fertility in animals (see Non-clinical Information). There is no information on the effects of guaiphenesin on human fertility. Pregnancy Administration of drugs during pregnancy should only be ...
Extract from Clinical Evaluation Report: Ivermectin
Extract from Clinical Evaluation Report: Ivermectin

The Genetics of Migraine
The Genetics of Migraine

... symptoms (20%), in which at least one family member has nystagmus or ataxia.13,25,26 FHM is characterised by large clinical variability in the severity and frequency of attacks among individuals belonging to different families but also within the same family.13,15,16 Besides familial cases, some spo ...
Methotrexate - Pfizer Canada
Methotrexate - Pfizer Canada

... Methotrexate has the potential for acute and chronic hepatotoxicity. Acutely, liver enzyme elevations are frequently seen after Methotrexate administration and are usually not a reason for modification of Methotrexate therapy. Liver enzyme elevations are usually transient and asymptomatic, and also ...


... clearance < 20 ml / min (see sections 4.2 and 5.2). There are insufficient data regarding use of cefixime in the pediatric and adolescent age group in the presence of renal insufficiency. Therefore, the use of cefixime in these patientgroups is not recommended. Renal function is to be monitored unde ...
Therapeutic Monitoring of Vancomycin in Adult Patients
Therapeutic Monitoring of Vancomycin in Adult Patients

... Vancomycin is a glycopeptide antibiotic that has been in clinical use for nearly 50 years as a penicillin alternative to treat penicillinase-producing strains of Staphylococcus aureus. It is one of the most widely used antibiotics in the United States for the treatment of serious gram-positive infec ...
Ampicillin
Ampicillin

... are characteristic of ampicillin and amoxicillin and often appear more than 7 days after starting treatment. Such rashes may be due to hypersensitivity to the beta-lactam moiety or to the amino group in the side-chain, or to a toxic reaction. The occurrence of a maculopapular rash during ampicillin ...
Neuroscience of psychoactive substance use and dependence
Neuroscience of psychoactive substance use and dependence

... strategies. The various health and social problems associated with use of and dependence on tobacco, alcohol and illicit substances require greater attention by the public health community and appropriate policy responses are needed to address these problems in different societies. Many gaps remain ...
American Thoracic Society Documents
American Thoracic Society Documents

... CCHS. Over 90% of CCHS cases will be heterozygous for an inframe PARM coding for 24 to 33 alanines in the mutated protein and producing genotypes of 20/24 to 20/33 (the normal genotype would be referred to as 20/20). The remaining approximately 10% of patients with a classical CCHS phenotype will be ...
Product Monograph - Paladin Labs Inc.
Product Monograph - Paladin Labs Inc.

... Indomethacin: Glucagon may lose its ability to raise blood glucose or paradoxically may even produce hypoglycemia (13). Warfarin: Glucagon may increase the anticoagulant effect of warfarin (2). Beta-blockers: Patients taking beta-blockers might be expected to have a greater increase in both pulse an ...
product monograph
product monograph

... Patients with severe liver impairment should be administered a lower initial dose because they may have reduced clearance of loratadine; an initial dose of one tablet daily is recommended. Use in Elderly: In patients 60 years of age or older, sympathomimetics are also more likely to cause adverse re ...
EAU Guidelines Male Sexual Dysfunction 2013
EAU Guidelines Male Sexual Dysfunction 2013

... Epidemiological data have shown a high prevalence and incidence of ED worldwide. The first large, community-based study of ED was the Massachusetts Male Aging Study (MMAS) (3). The study reported an overall prevalence of 52% ED in non-institutionalised 40-70-year-old men in the Boston area; specific ...
FLUOROQUINOLONES - American Academy of Veterinary
FLUOROQUINOLONES - American Academy of Veterinary

... years of age, except as a last resort for severe infections not treatable with other medications.{R-25; 26; 85} Although there have been reports of unpublished studies showing articular damage from enrofloxacin administration to adult horses, subsequent studies have shown no effect on cartilage in a ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... Abstract: Cutis laxa is a rare condition involving the skin. There is loss of resilience, texture and quality of skin. The inherited form of cutis laxa is rather uncommon. Some 400 families have been reported in literature until now. The majority of the various subtypes of cutis laxa syndromes affec ...
Makena - HCP Home Makena® (hydroxyprogesterone caproate
Makena - HCP Home Makena® (hydroxyprogesterone caproate

... birth in women with a singleton pregnancy who have a history of singleton spontaneous preterm birth. The effectiveness of Makena is based on improvement in the proportion of women who delivered <37 weeks of gestation. There are no controlled trials demonstrating a direct clinical benefit, such as im ...
2nd Quarter Conference Call
2nd Quarter Conference Call

...  10mg Eligen® group served essentially as a pilot arm to determine appropriate dose for pharmacokinetic purposes  Following these results, dosage reduced by 50% to a level that is being used in certain commercially available formulations  Expect to be able to reduce dose further based on the data ...
Ceftolozane (as sulfate) / Tazobactam (as sodium salt)
Ceftolozane (as sulfate) / Tazobactam (as sodium salt)

... combined (n = 30). No dose adjustment is recommended based on ethnicity. CLINICAL TRIALS Zerbaxa (ceftolozane/tazobactam) demonstrated clinical and microbiological efficacy against ESBLproducing E. coli (CTX-M-14/15 producing isolates) and K. pneumoniae (CTX-M-15 producing isolates) in two well-cont ...
Clearing of Metabolic Waste via Enterohepatic Recirculation Table
Clearing of Metabolic Waste via Enterohepatic Recirculation Table

... Thesis statement: The nature of bile lends itself to the recycling of metabolic waste, causing these waste products to reenter the blood stream through the process known as enterohepatic recirculation. This recycling could possibly become a concern as exposure to potentially harmful waste products i ...
CV - Faculty of Pharmaceutical Sciences
CV - Faculty of Pharmaceutical Sciences

... methadone. In the case of valproic acid saliva levels are very pH dependent and vary with the method of collection. Metabolite levels in saliva may also predict relative tissue distribution of some highly protein bound metabolites. ii) Drug metabolism studies: A very large project is the investigati ...
Dominant and Recessive Inheritance Patterns of
Dominant and Recessive Inheritance Patterns of

... individuals found in the northern population. Reciprocal crosses and backcrosses indicated that the nondiapause phenotype in the snd was inherited in a recessive manner, and a single locus is responsible for the nondiapause phenotype. Ignatowicz and Helle (1986) and Goka and Takafuji (1990) also rep ...
PIPERINE, AN ALKALOID DERIVED FROM BLACK
PIPERINE, AN ALKALOID DERIVED FROM BLACK

... building blocks or biochemical co-factors which are not subject to the biotransformation process. Thus, a major obstacle to improved nutrient status for nutrients is the ability or the efficiency to cross the gastrointestinal barrier, rather than a concern about premature elimination from the circul ...
What is the nutrient? Selenium. What is the RDA/DRI for the nutrient
What is the nutrient? Selenium. What is the RDA/DRI for the nutrient

... Using dimercaprol together with selenium can cause injury to the kidneys. Selenium may slow blood clotting. Taking selenium along with anticoagulant medications might increase the chances of bruising and bleeding. Taking selenium, beta-carotene, vitamin C, and vitamin E together might decrease the e ...
Selenium - Katie Davis
Selenium - Katie Davis

... Using dimercaprol together with selenium can cause injury to the kidneys. Selenium may slow blood clotting. Taking selenium along with anticoagulant medications might increase the chances of bruising and bleeding. Taking selenium, beta-carotene, vitamin C, and vitamin E together might decrease the e ...
gemini Documentation
gemini Documentation

METHOTREXATE 25 MG/ML SOLUTION FOR INJECTION
METHOTREXATE 25 MG/ML SOLUTION FOR INJECTION

... The application and dosage recommendations for the administration of methotrexate (low-dose therapy, mostly as part of polychemotherapy) for different indications varies considerably. Some common dosages and therapy protocols, which have proved to be efficacious in the therapy of the disorder in eac ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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