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P1507962 Piperacillin And Tazobactam For Injection Leaflet
P1507962 Piperacillin And Tazobactam For Injection Leaflet

... C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients wh ...
RESEARCH 123 Acute Cocaine Intoxication:
RESEARCH 123 Acute Cocaine Intoxication:

... Inherent in the development of any new medication is a series of studies designed to determine medication safety for ethical reasons. These studies must be conducted in animals before the medication is given to humans. Generally, toxicity studies are tests that directly identify and quantify the adv ...
Sub-Lingual Immunotherapy - World Allergy Organization
Sub-Lingual Immunotherapy - World Allergy Organization

... manufacturing sector noticed that physicians had changed their prescribing patterns, and were now requesting single specific allergens for immunotherapy, rather than the allergen mixtures that had previously been supplied. In the 1990s, when sublingual immunotherapy first appeared on the market, the ...
drug registration guidance document (drgd) - NPRA
drug registration guidance document (drgd) - NPRA

... First Edition - January 2013 ...
Cannabis Report of the Swiss Federal Commission For Drug Issues
Cannabis Report of the Swiss Federal Commission For Drug Issues

... situation regarding drugs in Switzerland and of the current need for action. Its predecessor (the Subcommission for Drug Issues attached to the Federal Narcotics Commission which was disbanded in 1996) had always assumed the view all illegal drugs were equivalent, as the basis for its discussions an ...
Salvia Divinorum
Salvia Divinorum

... ----------------------------------------------------------------The long-term effects of Salvia Divinorum abuse are unknown, as medical studies undertaken to examine the drug's physiological effects have focused only on short-term effects. However, information provided by abusers indicates that the ...
OMEPRAZOLE
OMEPRAZOLE

... with H pylori infection and duodenal ulcer disease. Therapy will continue from 14 to 28 days depending on if an ulcer is present at initiation of therapy. In patients who fail therapy, dual therapy with clarithromycin is more likely to be associated with clarithromycin resistance than triple-drug th ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights

... Persons who are using drugs that suppress the immune system are more susceptible to infections than healthy individuals. Chickenpox and measles, for example, can have a more serious or even fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not ...
Poisoning and Drug Overdose
Poisoning and Drug Overdose

... omissions or for the results obtained from use of the information contained in this work. Readers are encouraged to confirm the information contained herein with other sources. For example and in particular, readers are advised to check the product information sheet included in the package of each d ...
Therapeutic monitoring of vancomycin in adult patients
Therapeutic monitoring of vancomycin in adult patients

... vancomycin activity against VISA, heteroresistant VISA (hVISA), and MSSA in the murine neutropenic mouse model. They found that the fAUC/MIC requirement varied depending on the vancomycin MIC and was a function of bacterial density at the site of infection, with a lower fAUC/MIC needed for a lower b ...
Discriminative Stimulus Properties of MDMA
Discriminative Stimulus Properties of MDMA

... part 2 of Class B in the Misuse of Drugs act in 1975 but this status was recently elevated to part 1 in 2005 ("Misuse of Drugs Act," 1975). The current penalty for importing, manufacturing, or supplying MDMA is a maximum of 14 years imprisonment while possession alone can incur three months jail and ...
2012 Medical Marijuana for the Treatment of Migraine Headaches:
2012 Medical Marijuana for the Treatment of Migraine Headaches:

... use of marijuana and ectasy. There were two articles reporting a cross sectional study. One appears to be a subset of the other but this is not clear. Neither directly addresses the clinical question of effectiveness and both studies are of extremely low quality. ...
These highlights do not include all the information needed
These highlights do not include all the information needed

... adults of HPA axis suppression when they are treated with topical corticosteroids. They are, therefore also at greater risk of adrenal insufficiency during and/or after withdrawal of treatment. Pediatric patients may be more susceptible than adults to skin atrophy, including striae, when they are tr ...
diazepam interaction on methadone-induced - HAL
diazepam interaction on methadone-induced - HAL

... three injections of 1 mL of air into the chamber and the ambient temperature was noted. The spirogram was recorded and stored on a computer with an acquisition data card (PCI-DAS 1000, Dipsi, Chatillon, France) using respiratory acquisition software (Acquis1 Software, CNRS, Gif-sur-Yvette, France) ...
product monograph
product monograph

... Adverse effects including striae have been reported with use of topical corticosteroids in infants and children. HPA axis suppression, Cushing’s syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. ...
Potential applications of chitosan in veterinary medicine
Potential applications of chitosan in veterinary medicine

... Chitosan is a partially deacetylated polymer obtained from the alkaline deacetylation of chitin which is a glucose-based unbranched polysaccharide widely distributed in nature as the principal component of exoskeletons of crustaceans and insects as well as of cell walls of some bacteria and fungi. C ...
TAXUS® Liberté™
TAXUS® Liberté™

... • Stent thrombosis is a low frequency event that current drug-eluting stent (DES) clinical trials are not adequately powered to fully characterize. Stent thrombosis is frequently associated with myocardial infarction (MI) or death. Data from TAXUS Stent randomized clinical trials have been evaluate ...
Methamphetamine - Department of Electrical Engineering
Methamphetamine - Department of Electrical Engineering

... Methamphetamine and amphetamine are often measured in urine, sweat or saliva as part of a drug-abuse testing program, in plasma or serum to confirm a diagnosis of poisoning in hospitalized victims, or in whole blood to assist in a forensic investigation of a traffic or other criminal violation or a ...
B N ULLETI I N F O R M A T I O...
B N ULLETI I N F O R M A T I O...

... on college campuses. At these venues GHB analogs usually are sold for $10 to $20 per capful (approximately 1 teaspoonful). When distributors sell these drugs, they may fail to specify which analog they are selling, or they may misrepresent the analog as GHB. GHB analogs also are distributed at disre ...
This is the breakthrough of Lithium Orotate
This is the breakthrough of Lithium Orotate

... Ward Dean, M.D., author of “The Unique Safe Mineral with Multiple Uses”: “The lithium salt of orotic acid (lithium orotate) improves the specific effects of lithium manyfold by increasing lithium bio-utilization.” (Ward Dean, M.D.) (14) “Lithium orotate has also been used with success in alleviating ...
Piracetam: A Review of Pharmacological
Piracetam: A Review of Pharmacological

... Piracetam should not be prescribed to patients with cerebral hemorrhage. While reproductive studies in animals have not identified any risk to the fetus, studies in humans have not been conducted and so the use of piracetam in pregnant or lactating women should be avoided. Piracetam is neither metab ...
product monograph - Takeda Canada Inc.
product monograph - Takeda Canada Inc.

... patients with severe hepatic or renal dysfunction since currently no data are available on the efficacy and safety of pantoprazole in combination treatment of these patients. Endocrine and Metabolism Hypomagnesemia Hypomagnesemia, symptomatic and asymptomatic, has been reported in patients treated w ...
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended
Hydrocodone Polistirex and Chlorpheniramine Polistirex Extended

... Extended-Release Oral Suspension did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, d ...
PHARMACEUTICAL SUPPOSITORIES & PESSARIES Ms.WAJIHA
PHARMACEUTICAL SUPPOSITORIES & PESSARIES Ms.WAJIHA

... 2. It gives suppositories that are more elegant than hand moulded suppositories. 3. In this method sedimentation of solids in the base is prevented. 4. Suitable for heat labile medicaments.  **Disadvantages: 1.Air entrapment may take place. 2.This air may cause weight variation. 3.The drug and/or t ...
Greater Sensitivity to Subjective Effects of Nicotine in Nonsmokers
Greater Sensitivity to Subjective Effects of Nicotine in Nonsmokers

... sensitivity. Animals that are initially more sensitive to nicotine (Collins, Miner, & Marks, 1988) or other drugs (Cools & Gingras, 1998) typically develop the greatest chronic tolerance after long-term drug exposure and become equally as sensitive as, or less sensitive than, initially insensitive a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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