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Powerpoint
Powerpoint

... return for formulary position with drug manufacturers “on behalf of plans” PBM has duty to act on behalf of principal 18 U.S.C. 1346 PBM has duty not to solicit or accept improper payments from manufacturers to affect their judgment or advice to clients ...
Sedatives
Sedatives

... use, such as euphoria, disinhibition, enhanced sensuality and empathogenic states. At higher doses, GHB may induce nausea, dizziness, drowsiness, agitation, visual disturbances, depressed breathing, amnesia, unconsciousness, and death. The effects of GHB can last from 1.5 to 3 hours, or even longer ...
File
File

Prescription Of Anxietyolitic Medications For Persons
Prescription Of Anxietyolitic Medications For Persons

... The SSRIs have relatively few side effects in patients; however, drug-induced akathisia can resemble worsening of anxiety. Akathisia is an inner sense of restlessness that resembles anxiety and produces agitation or excessive motor activity. Some patients may develop hyponatremia. The combined use o ...
Lan Mai - Cystic Fibrosis
Lan Mai - Cystic Fibrosis

... Cystic Fibrosis was diagnosed based on phenotypic features. (1) Chronic Sinopulmonary Disease – constant coughing and sputum, wheezing and air trapping, obstructive lung disease on lung function tests, etc. (2) Nutritional Abnormalities – mal-absorption, pancreatic insufficiency, fatsoluble deficien ...
17th European Congress of Clinical Microbiology and
17th European Congress of Clinical Microbiology and

... Aspergillus galactomannan antigen can be very effective in determining the need for pre-emptive therapy. He described a screening study of these techniques which showed that it was possible to reduce empirical antifungal use from 35% to 7.7% of treatment episodes, with an accompanying 63.6% survival ...
Variations to Mendel`s First Law of Genetics
Variations to Mendel`s First Law of Genetics

... 3. One member of the gene pair segregates into a gamete, thus each gamete only carries one member of the gene pair. 4. Gametes unite at random and irrespective of the other gene pairs involved. ...
Common Injuries to the Knee
Common Injuries to the Knee

... be given IV or IM • Chronic, Severe pain: narcotics See Table 3 for commonly used analgesic drugs ...
The MHIF System Supporting the Health Impact Fund with Mobile
The MHIF System Supporting the Health Impact Fund with Mobile

... accounts with their personal ID using a SIM card. Patients can purchase HIFregistered drugs by transferring money from their HIF account using a mobile-phone banking system. All transactions, with their GPS location, will be recorded in a central database. In addition, once patients have received me ...
01_introduction- tox
01_introduction- tox

... Laboratory Medicine practice guidelines: recommendations for the use of laboratory tests to support poisoned patients who present to the emergency department. Clin Chem 2003;49:357–79. Skelton H., Dann L.M., et al. Drug screening of patients who deliberately harm themselves admitted to the emergenc ...
McLean 2000 - American Geriatrics Society
McLean 2000 - American Geriatrics Society

... Management of withdrawal from BCAs There are no data on withdrawal from BCAs A reasonable management approach would include: -trial discontinuation only attempted with the patients cooperation -single source of prescribed medication required -slow rather than abrupt discontinuation -refer to substan ...
Document
Document

... Recommended text amendments for SmPC Section 4.2 Posology and route of administration Treatment of anxiety The usual anxiolytic dose for adults and adolescents over 15 years of age is 20-30 mg daily in divided doses or as a single dose given at night. Doses up to 60mg daily have been used in the tre ...
Mendel`s Principles
Mendel`s Principles

... Each pair of homologous chromosomes carries genes that govern the same traits. For example, in pea plants, flower color is determined by a single gene F, which can have two different forms, F or f, called alleles. Every cell in the diploid plant has two copies of the gene, one on each member of a ho ...
Clinical Pharmacists and Inpatient Medical Care
Clinical Pharmacists and Inpatient Medical Care

... of hospitalized patients has evolved over time, with increased emphasis on collaborative care and patient interaction. The purpose of this review was to evaluate the published literature on the effects of interventions by clinical pharmacists on processes and outcomes of care in hospitalized adults. ...
A comparative study of survivial models for breast cancer
A comparative study of survivial models for breast cancer

... prognosis. • Several research teams conducted comprehensive genome-wide assessments of gene expression profiling and identified prognostic gene expression signatures. • With respect to clinical guidelines, these signatures were shown to correctly identify a larger group of low-risk patient not requi ...
Source - Gilberto De Nucci
Source - Gilberto De Nucci

... (2838 [37.4%]). One-year incidence of PIM use was 42.1%. Incident PIM users were more likely to be hospitalized (odds ratio [OR] = 1.27; 95% CI, 1.10-C1.46) and more likely to die (OR = 1.46; 95% CI, 1.31-C1.62) in the 12 months after first receiving a PIM than nonusers, even after adjusting for dem ...
Introduction Drug interference Validity of control and
Introduction Drug interference Validity of control and

... Immunogenicity assay performance was determined in different species matrices and different formats were compared. Assay performance can vary significantly in different species matrices, even if a species independent assay format is used ...
SSRIs for the treatment of Anxiety Disorders in children
SSRIs for the treatment of Anxiety Disorders in children

Adverse Event Record - Global Health Trials
Adverse Event Record - Global Health Trials

... If study medication was interrupted, stopped or dose reduced: Was study medication reintroduced (or dose increased)? Yes No If yes, did SAE recur? Yes No ...
A human laterality disorder associated with a homozygous
A human laterality disorder associated with a homozygous

... similarly, Spag1 variants cause hydrocephalus in fish but PCD in human.12 There is a growing body of evidence that these two laterality disorders, SIT and HS, are actually part of a phenotypic continuum, underlined by the same genetic defects. Variants in the ZIC3 gene, which are thought to account f ...
Biren Patel King`s College London 1 Community Care for Older
Biren Patel King`s College London 1 Community Care for Older

... Numerous studies have shown that polypharmacy increases the risk of ADRs in older patients (4,15). Field et al investigated the incidence of ADEs in 18 nursing homes. Over the course of 12 months the team identified 410 ADEs amongst the combined residents (n=2916). The most common ADEs included neur ...
epilepsy - Bradford VTS
epilepsy - Bradford VTS

... AIM: The study was designed to examine the process of care for people with epilepsy through a region-wide audit of general practitioner records. METHOD: General practitioners in 31 randomly selected general practices in one UK health region undertook a notes audit for all patients identified as havi ...
Mock Exam 1 gibson
Mock Exam 1 gibson

... 44. Why is Mendel's contribution to genetics called a particulate theory? ...
Dispatch Human Evolution: Thrifty Genes and the Dairy Queen Greg
Dispatch Human Evolution: Thrifty Genes and the Dairy Queen Greg

... thirteenth intron of the MCM6 gene, which lies14 kilobases upstream of LCT. They both drive elevated expression of a reporter gene in intestinal cell lines, and both explain a sizeable portion of lactose tolerance in their respective populations. It is possible to estimate whether there has been pos ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... 5. The presentation of this case makes dental examination for sharp cusps mandatory for all patients who will be administered warfarin. 6. The dental examination for sharp cusps mandatory for all patients who will be administered warfarin. In the present case, sublingual and buccal vestibule hematom ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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