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glucagon - DavisPlus
glucagon - DavisPlus

... Assess for nausea and vomiting after administration of dose. Protect patients with depressed level of consciousness from aspiration by positioning on side; ensure that a suction unit is available. Notify health care professional if vomiting occurs; patient will require parenteral glucose to prevent ...
Print this article - Annals of Gastroenterology
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... adenomatous polyposis (FAP), an autosomal dominant trait linked with germ-line mutations in the adenomatous polyposis coli gene (APC).1-3 APC encodes a tumor – suppressor protein, that controls proliferation of the colonic epithelial cells. APC gene mutations are thus associated with overexpresssion ...
DAWN  GLOSSARY,  2011 UPDATE
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... accidental ingestion of a drug, for example, childhood drug poisonings and individuals who take the wrong medication by mistake. It includes a caregiver administering the wrong medicine by mistake. It does not include a patient taking more medicine than directed because the patient forgot to take it ...
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... stable and efficacious. After September 29, 1978, pharmaceutical manufacturers in the United States had to place expiration date on medications as required by the Food and Drug Administration regulation, Current Good Manufacturing Practice (CGMP) Subpart G Section 211.1371. The law is to, “…assure t ...
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Genetics Review
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Drug Interactions—Principles, Examples and Clinical Consequences
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... to ease intractable pain in cancer patients, for example. In this article, we begin by looking at the first commercial drugs to be developed, the pain medications morphine and aspirin and their related compounds. Then we follow the discovery of antibiotics to more recent findings about our own cells ...
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... •  Similar dose response for ADA detection in the absence of drug as the bridging assay without acid •  Percent recoveries are acceptable with 1 µg/mL of Drug but reduced to 35% at the 125 ng/mL of ADA with 10 µg/mL of Drug. •  The assay sensitivity was maintained for the 1 and 10 µg/mL of drug at a ...
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... Continued from page 1 18 months, and the company’s first foray into large molecules. “Beigene, as new as it is, now has experience in both small molecule and biologics. We have experience in solid and hematological cancers, as well as experience in targeted and immuno-oncology therapies,” Jason Yang ...
Powerpoint
Powerpoint

... return for formulary position with drug manufacturers “on behalf of plans” PBM has duty to act on behalf of principal 18 U.S.C. 1346 PBM has duty not to solicit or accept improper payments from manufacturers to affect their judgment or advice to clients ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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