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Genetics: A Scientific Revolution
Genetics: A Scientific Revolution

... Heredity: transmission of traits from parents to offspring Inheritance: genes acquired by offspring ...
Source - Gilberto De Nucci
Source - Gilberto De Nucci

... (2838 [37.4%]). One-year incidence of PIM use was 42.1%. Incident PIM users were more likely to be hospitalized (odds ratio [OR] = 1.27; 95% CI, 1.10-C1.46) and more likely to die (OR = 1.46; 95% CI, 1.31-C1.62) in the 12 months after first receiving a PIM than nonusers, even after adjusting for dem ...
Identification and functional characterization of mutations and/or polymorphisms in FAT10 gene to elucidate the role of these mutations/polymorphisms in the carcinogenesis process.
Identification and functional characterization of mutations and/or polymorphisms in FAT10 gene to elucidate the role of these mutations/polymorphisms in the carcinogenesis process.

... expressed genes in match tumor/adjacent normal tissues. One of the differentially expressed genes, FAT10, is particularly intriguing because its gene expression is highly up-regulated in most tumor tissue and it was not previously associated with cancer. FAT10 is a member of the ubiquitin-like modif ...
Introduction of the AmpliChip CYP450 Test to a prospective cohort study
Introduction of the AmpliChip CYP450 Test to a prospective cohort study

... CYP2C19 were very similar between the two different cohorts. The CYP2D6 XL-PCR + Sequencing platform detected CYP2D6*5 more reliably and could correctly distinguish between CYP2D6*2 and *41 in the Black African individuals. Alleles not covered by the AmpliChip were identified and four novel CYP2D6 a ...
Pharmacology—Antipsychotic Drug Therapy
Pharmacology—Antipsychotic Drug Therapy

... Fluphenazine, Ziprasidone, and Molindone 3) The newest agent, Aripriprazole, appears to have minimal effect on weight gain but is least effective in treating schizophrenia Antipsychotic Therapy and Cardiac Effects Increased attention has been focused recently on understanding the cardiac effects of ...
Detection of the pharmaceutical agent glaucine as a recreational drug
Detection of the pharmaceutical agent glaucine as a recreational drug

... 0.7 mg/L should therefore only be considered an approximation. Extended toxicological screening did not detect ethanol or any other drugs, except for cyclizine, which was administered in the ED. Glaucine is an antitussive agent used therapeutically in several countries in the European Union, such as ...
Drugs of Abuse: Psychedelic Agents
Drugs of Abuse: Psychedelic Agents

... They have been explored as potential therapeutic agents in treating depression, post-traumatic stress disorder,alcoholism, cluster headaches, and other ailments.  Early military research focused on their use as incapacitating agents and or interrogation.  The most popular, and at the same time mos ...
Animal Genetics Topic 3033 Genotype and Phenotype
Animal Genetics Topic 3033 Genotype and Phenotype

... DNA to RNA to protein Protein codes for genes Genes code for traits Each chromosome pair contains many gene pairs ...
KORA-gen – Resource for Population Genetics, Controls and a
KORA-gen – Resource for Population Genetics, Controls and a

... Now this collection will be opened also for external researchers, under the name KORA-gen [33]. The objective of KORA-gen is to provide access to information about available population controls for genetic studies as well as provision of DNA samples, genotypic and phenotypic data. The KORA-gen infra ...
Vol. 4 (3) -March 2009
Vol. 4 (3) -March 2009

WHO Drug Information Contents Safety and Efficacy Issues
WHO Drug Information Contents Safety and Efficacy Issues

... paediatricians) on a voluntary basis, and it is currently in the clinical validation phase. One of the important advantages of this database is that health data are anonymous, ensuring confidentiality of patient identity. Sometimes the study we need is not an aetiologyoriented one but merely a drug ...
genetics in primary care
genetics in primary care

... do you assess for possible IHD?  Children should be started on a statin as early as possible, around the age of 10 ...
Welcome to the Genetics portion of IB 201!
Welcome to the Genetics portion of IB 201!

... Not bald Not bald ...
Genetics
Genetics

... e) genetic variation (mutation, recombination, deletions, additions to DNA); h) useof genetic information; and i) exploration of the impact of DNA ...
Off-label utilization of antipsychotics
Off-label utilization of antipsychotics

... pharmacological profile in comparison to the conventional antipsychotics. This has led to broad off-label utilisation. The aim of the present survey was to study the prescribing practice of hospital psychiatrists with regard to antipsychotic drugs, comparing patients treated for psychoses or other r ...
SEDATIVE/HYPNOTICS (Antianxiety Drugs)
SEDATIVE/HYPNOTICS (Antianxiety Drugs)

... Biotransformation of Benzodiazepines 1. the kinetics of the parent drug may not reflect the time course of the pharmacological effect. 2. Estazolam, oxazepam, and lorazepam, which are directly metabolized to glucoronides have the least residual (drowsiness) effects. 3. All of these drugs and their ...
Psychiatry and Pain Management
Psychiatry and Pain Management

... Dissociation is when a person loses track of time and/or person, and instead finds another representation of their self in order to continue in the moment. A person who dissociates often loses track of time or themselves and their usual thought processes and memories. People who have a history of an ...
Name: Date: Bell: Reviewing Concepts Multiple Choice Choose the
Name: Date: Bell: Reviewing Concepts Multiple Choice Choose the

... Traits of 2 parents blend. Did not not explain how traits could disappear in F1 generation and reappear in the F2 generation 10. List the possible combinations of alleles in the gametes of an individual with genotype AaBb. AB, Ab, aB, ab 11. Explain Mendel's principle of independent assortment. When ...
vancomycin (van-koe-mye-sin) - DavisPlus
vancomycin (van-koe-mye-sin) - DavisPlus

... Plate # 0-Composite ...
wonder drugs usually aren`t your best bet
wonder drugs usually aren`t your best bet

... was lined with mile after mile of palm oil plantations. Then, in 1984, while working for NCI at USDA I brought some red palm oil from Senegal (formerly French West Africa) and it tested for very high levels of pre-vitamin A carotenoids. But conservationists warn that the recent surge in interest in ...
Sodium Oxybate Reduces Fibromyalgia Pain and Fatigue
Sodium Oxybate Reduces Fibromyalgia Pain and Fatigue

... the brain that is not targeted by other therapies. "This uniqueness of this drug is probably not simply that it is working in part by improving sleep, because other drugs, such as tricyclics and gabapentin/pregabalin, are also likely working in part by improving sleep," he said. "The more exciting p ...
Handling Drug / Tube Feeding Interactions
Handling Drug / Tube Feeding Interactions

... interactions at your institution • Describe various techniques for avoiding potential drug / tube feeding interactions • Develop a method for avoiding potential drug / tube feeding interactions when specific recommendations are not available ...
antiepileptic drug selection for people with hiv/aids
antiepileptic drug selection for people with hiv/aids

... A retrospective cohort study and numerous pharmacokinetic studies indicate that EI-AEDs interact with ARVs. The optimal choice of epilepsy treatment in patients with HIV should reflect an accounting for the metabolic and inhibitory/inducing profiles of coadministered drugs. Clinicians who prescribe ...
LECTURE 1 - Berkeley MCB
LECTURE 1 - Berkeley MCB

... inheritance: (1) one of the two alleles of a given gene showed complete dominance over the other, (2) there are only two alleles of any given gene, (3) genes determine one specific trait, and (4) all genotypes are equally viable. When these guidelines are not meet, deviations from expected Mendelian ...
document - Herts Valleys CCG
document - Herts Valleys CCG

... Ranibizumab is recommended as an option for treating visual impairment due to diabetic macular oedema only if:  the eye to be treated has a central retinal thickness of 400 micrometres or more at the start of treatment and  the manufacturer provides ranibizumab with the discount agreed in the pati ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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