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CAREMARK
CAREMARK

... 4. FDA MedWatch. Fentora (fentanyl buccal tablet). Food and Drug Administration Web site. http://www.fda.gov/medwatch/safety/2007/safety07.htm#Fentora. Accessed September 27, 2007. 5. FDA MedWatch. Viracept (nelfinavir mesylate). Food and Drug Administration Web site. http://www.fda.gov/medwatch/saf ...
SAMi_IS_2013 - updated
SAMi_IS_2013 - updated

... $8.9B Problem in Asthma  SALBUTAMOL (a.k.a. Albuterol) is the ONLY short-acting bronchodilator – several “me toos” - all act via same B-adrenergic pathway  $1.6B sales, 4th most prescribed, 15th highest selling GENERIC worldwide ...
Acetylation
Acetylation

A STUDY ON PRESCRIBING PATTERN OF ANTI MICROBIAL AGENTS IN... INTENSIVE CARE UNIT OF A TERTIARY CARE TEACHING HOSPITAL IN...
A STUDY ON PRESCRIBING PATTERN OF ANTI MICROBIAL AGENTS IN... INTENSIVE CARE UNIT OF A TERTIARY CARE TEACHING HOSPITAL IN...

... with a mean age of around 53 years, similar to a study done in Bangalore by Lisha et al [8]. Smythe et al [3] study done outside India did show that equal numbers of male and female patients were admitted to the medical ICU with a mean age of 65 years. The reason for more male admissions in our stud ...
Use of Opioids for the Treatment of Chronic Pain
Use of Opioids for the Treatment of Chronic Pain

Introduction to Pharmacology 2 General Principles: Absorption
Introduction to Pharmacology 2 General Principles: Absorption

...  Your patient overdoses on BAYER aspirin. Would it be better to give an acidifying agent such as ammonium chloride or Vitamin C, or alkalinizing agent such as sodium bicarbonate or sodium citrate? biliary and fecal excretion  secretion of conjugates in bile  bile salt residue reabsorbed & excrete ...
Mechanisms of Data Release and Sharing
Mechanisms of Data Release and Sharing

... produced by this program have additional utility to the biomedical research community, including, but not limited to, identifying other disease genes, testing genotype-phenotype relationships, and exploring genetic and molecular mechanisms of disease. Therefore, it ...
Identification of two rare APOE mutations associated with Familial
Identification of two rare APOE mutations associated with Familial

... family history plus lipid levels (based on the pre-treatment LDL-C estimator) to provide a genotyping score and indication of whether or not to proceed with a genotyping referral. Qualitative evaluation of the tools has been used to refine these for use in the clinical setting. Both tools have been s ...
IN VITRO ACECLOFENAC SODIUM FOR PERIODONTITIS  Research Article
IN VITRO ACECLOFENAC SODIUM FOR PERIODONTITIS Research Article

... to rest of the body parts leads to potential side effects. This problem can be overcome by administering the drug directly to the intended site of action with lesser dose3. The local production of prostaglandins and other metabolites of arachidonic acid within the periodontal tissues contribute to a ...
Genetics Notes
Genetics Notes

...  Crossed purple anthers and white stigmas  Produced only purple ...
PROVISIONAL ANSWER KEY NAME OF THE POST
PROVISIONAL ANSWER KEY NAME OF THE POST

... (D) Fusion weapons have a highly specific destructive effect. The heavier element produced from a fissions reaction, and the difference in mass from the two lighter nuclei (which is translated into an energy explosion) can be precision calculated. Bombs even within the multi-megaton range have unlim ...
90459 Genetic Variation answers-05
90459 Genetic Variation answers-05

... All rights reserved. No part of this publication may be reproduced by any means without prior permission of the New Zealand Qualifications Authority. ...
Acute Poisoning Emergencies
Acute Poisoning Emergencies

... This creates a delay of sodium entry into the cardiac myocyte during phase 0 of depolarization. As a result, the upslope of depolarization is slowed and the QRS complex widens.10 In some cases, the QRS complex may take the pattern of recognized bundle branch blocks.11,12 In the most severe cases, th ...
Multiple Drug Ingestion For Suicidal Purpose Alprazolam
Multiple Drug Ingestion For Suicidal Purpose Alprazolam

... Gaziantep Týp Dergisi 2008, 14:50-52. ...
Antiviral drugs
Antiviral drugs

... They must be phosphorylated by viral or cellular enzymes in order to become active. - Antiviral drugs typically have a restricted spectrum of antiviral activity and inhibit a specific viral protein, most often an enzyme involved in viral nucleic acid synthesis. - Single nucleotide changes leading to ...
DNA
DNA

... • Children inherit features from their parents • If two parents have a certain characteristic then their child may show it even more (e.g. Mr Small + Little Miss Tiny = Mr Very Small!) • Some things such as glasses, scars and muscles we get from our environment, they are not inherited. ...
Inheritance
Inheritance

... would get the same ratios of phenotypes & genotypes whenever you crossed heterozygotes. It was like clockwork!  This was because of independent assortment and segregation, which became known as “Mendal’s Laws” ...
Use of Advanced Computer Methods to Simplify the Analysis of
Use of Advanced Computer Methods to Simplify the Analysis of

... However … • Paradigm in traditional statistics and epidemiology – Harm, has to be pre-specified – but experts do not know how to pre-specify harm, patients at risk, and records to study in a systematic way ...
SNP Applications
SNP Applications

... Human Genome and SNPs • Now that the human genome is (mostly) sequenced, attention turning to the evaluation of variation • Alterations in DNA involving a single base pair are called single nucleotide ...
Genetic Disorders - Sarah E. Goode STEM Academy
Genetic Disorders - Sarah E. Goode STEM Academy

... Research into the human genome has given scientists a greater understanding of how genetic diseases progress. ...
docx #19692 - Studybay.com
docx #19692 - Studybay.com

... Mr. Buchanan requires an optimal surveillance that would provide any medical information regarding the management of hydrocortisone toxicity. The first step of nursing care should include the recording of the anthropometric measurements and the general physical signs of Mr. Buchanan. This would help ...
A Patient`s Guide to Taking Coumadin/Warfarin
A Patient`s Guide to Taking Coumadin/Warfarin

... ensures that PT results obtained by different laboratories can be compared. It is important to monitor the INR (at least once a month and sometimes as often as twice weekly) to make sure that the level of warfarin remains in the effective range. If the INR is too low, blood clots will not be prevent ...
New preclinical findings on Oseltamivir Case report of Cushing`s
New preclinical findings on Oseltamivir Case report of Cushing`s

... In an effort to improve the signals obtained from the spontaneous reports, HSA has stepped up its effort to promote ADR reporting amongst our healthcare professionals. Over the last year, more than 15 roadshows targeted at our doctors and pharmacists were conducted to promote the relevance of ADR re ...
corlanor
corlanor

... (If current) channel within the SA node that lowers heart rate • It causes a dose-dependent reduction in heart rate. Size of the effect is dependent on the baseline heart rate ...
monitoring of nsaids adverse effects based on spontaneous reports
monitoring of nsaids adverse effects based on spontaneous reports

... association between the incidence of adverse reactions to anti-inflammatory and analgesic drugs and gender. Such discrepancy in obtained data results most probably from qualitative difference in the number of submitted reports (8, 16). It is worth noting that all ADR reports submitted to The Regiona ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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