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drug interactions - Liverpool John Moores University
drug interactions - Liverpool John Moores University

... Marginal cases. Reduced blood levels could easily cause clinical problems, but increased levels probably less of a problem. Pharmacokinetic Drug Interactions ...
DEA Compliance and Drug Diversion 2014 NPPA Conference
DEA Compliance and Drug Diversion 2014 NPPA Conference

... must be kept of the receipt and disposition of all scheduled drugs Records of all scheduled drugs must be maintained and any discrepancies in count reconciled promptly Must be capable of quickly identifying loss or diversion of controlled substances and determining the extent of the diversion Must h ...
The Use of Propensity Scores and Instrumental Variable Methods to Adjust for Treatment-Selection Bias
The Use of Propensity Scores and Instrumental Variable Methods to Adjust for Treatment-Selection Bias

... the source of confounding. The goal of IV analyses is to find instruments that are correlated with treatment selection but are not directly correlated with the outcome variable. When variables are found, the IV creates variance to estimate the effect of treatment on the outcome. A special issue of H ...
Learning Grid Cellular control
Learning Grid Cellular control

... __________, and __________. Meiosis is an example of sexual reproduction and this produces __________ __________. One example of this is __________ __________ during prophase I, where homologous chromosome pairs come together to form __________. Reassortment of chromosomes in and reassortment of ___ ...
a PDF version of the Genetics Learning Framework
a PDF version of the Genetics Learning Framework

... repeat (STR), and explain how SNPs and STRs can be used as genetic markers even if they do not cause phenotypic changes. • Discuss how DNA is packaged in the chromosomes in terms of histones, nucleosomes, and chromatin • Explain the meaning of ploidy (haploid, diploid, aneuploid etc.) and how it rel ...
Warfarin - Lock Haven University
Warfarin - Lock Haven University

... Reversing effects with Vit K may take days Normal gut flora needed for Vit K conversion/absorption ...
Nonsense Mutations of the ZFHX1B Gene in Two Japanese Girls
Nonsense Mutations of the ZFHX1B Gene in Two Japanese Girls

... She was born to unrelated healthy parents at 37 gestational weeks with a weight of 2,700 g, a length of 47.6 cm and a head circumference of 31.5 cm. She showed tachypnea just after birth and was diagnosed as having a congenital heart disease complex including patent ductus arteriosus (PDA), ventricu ...
Cryopyrin-Associated Periodic Syndrome (CAPS) What is it
Cryopyrin-Associated Periodic Syndrome (CAPS) What is it

... reported symptoms include conjunctivitis and muscle pain. Symptoms usually begin 1–2 hours after generalized exposure to cold temperatures or to important variation of temperature, and the length of the attacks is usually short (less than 24 hours). These attacks are self-limited (meaning that they ...
Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug
Herbal / Drug Interactions PHARM 512: Clinical Applications of Drug

... From: Anderson and Elmer, Clinical Pharmacology and Therapeutics 43:643-648 (2003). ...
Mendelian Genetics
Mendelian Genetics

... Discuss what evidence you would give by explaining what gene-gene interrelationship is involved in each of the parents and using appropriate allele symbols, draw biochemical pathways to obtain an albino phenotype and a black phenotype. Clear well-labelled diagrams may be used to help you answer this ...
Honors Biology - WordPress.com
Honors Biology - WordPress.com

... As you study Figure 8.3 and 8.4 There are traits that are a dominate trait (they are represented by a Capital letter) There are traits that are a recessive (they are represented by a lower-case letter) ...
Chapter 7 PPT
Chapter 7 PPT

... • Medications may alleviate pain and improve patient’s well-being. • Used inappropriately, may cause harm and even death. ...
αPVP and MDPV Active Vaccine Attenuates Wheel Locomotor Behavior Introduction
αPVP and MDPV Active Vaccine Attenuates Wheel Locomotor Behavior Introduction

... phenylethylamine backbone. They are highly potent for both serotonin and dopamine transporters. These synthetic cathinones have been sold under the labels of “plant food”, “lab certified”, “not for human consumption” and “bath salts”. They also go by the terms “meow meow”, “flakka”, and “monkey dust ...
4.2 Posology and method of administration
4.2 Posology and method of administration

... malaria, the possibility of a clinically significant drug interaction cannot be ruled out. When given with efavirenz or boosted protease-inhibitors, atovaquone concentrations have been observed to decrease as much as 75%. This combination should be avoided whenever possible (see section 4.4) Proguan ...
HTN Meds Alpha 2 agonists Side effects Alpha 1 adrenergic
HTN Meds Alpha 2 agonists Side effects Alpha 1 adrenergic

... † Angioedema (laryngeal swelling) † Baseline K level 5mEq/L ...
Expanding the phenotype of IQSEC2 mutations: truncating
Expanding the phenotype of IQSEC2 mutations: truncating

... Shoubridge et al.7 In addition, 5/32 males also had seizures and 2/32 psychiatric disorders. Growth parameters including OFC were normal. Four different non-synonymous mutations in IQSEC2 were identified in these male patients. These mutations were predicted to lead to non-conserved amino acid subst ...
Off-Label Use of Pharmaceuticals: A Detection Controlled Estimation
Off-Label Use of Pharmaceuticals: A Detection Controlled Estimation

... Because of the incentives in the clinical-trials process, firms do not typically include a broad list of approved indications on their drugs’ labels. Part of the reason is that clinical trials center on demonstrating efficacy for a given indication, and the results of one approval (NDA) are often not t ...
14 – Mendel and the Gene Idea
14 – Mendel and the Gene Idea

... 6) EPISTASIS - Gene at one locus alters the phenotypic expression of a gene at another locus EX: Coat color pigment not deposited in hair without color gene; 7) PLEIOTROPY - one gene has multiple phenotypic effects EX: dwarfism; cystic fibrosis 8) MULTIFACTORIAL - Genetic component + environmental f ...
HIVART_7 - I-Tech
HIVART_7 - I-Tech

...  Toxicity (use lower dose to reduce risk of S/E development for patients < 60kg)  Peripheral Neuropathy (5-15%, pain, tingling, and numbness in ...
Erythropoiesis-stimulating agent protocol
Erythropoiesis-stimulating agent protocol

... be given as two 2.5-gram doses. Each dose is diluted in 100 mL of normal saline (or other diluent) and given over 7.5 minutes. It can be administered by emergency medical service personnel while patients are being transported to a hospital. The most common adverse effects reported in clinical trials ...
ACEIs and ARBs
ACEIs and ARBs

...  The direct renin inhibitor (DRI) aliskiren is one of the newest BP drugs, but there are  no completed or ongoing RCTs of aliskiren monotherapy.  “Dual RAS blockade” either with an ACEI plus an ARB or with aliskiren plus an ACEI or ARB—is now contraindicated. ...
pharmacokinetics
pharmacokinetics

... through lipid diffusion. The absorption takes place mainly in the upper small intestine. With oral administration of drugs, extensive gastrointestinal and hepatic metabolism may occur before the drugs are absorbed into systemic circulation and reach its site of action. This process is defined as the ...
Know Your Medications for Better Health
Know Your Medications for Better Health

... the pharmacist to explain how to take the drug properly, the side effects of the drug, and what to do if you experience side effects (just as you can with your physician). Make sure you receive written information about the medication. Inform your physician and pharmacist if you take any herbal or n ...
CAREMARK
CAREMARK

... 4. FDA MedWatch. Fentora (fentanyl buccal tablet). Food and Drug Administration Web site. http://www.fda.gov/medwatch/safety/2007/safety07.htm#Fentora. Accessed September 27, 2007. 5. FDA MedWatch. Viracept (nelfinavir mesylate). Food and Drug Administration Web site. http://www.fda.gov/medwatch/saf ...
SAMi_IS_2013 - updated
SAMi_IS_2013 - updated

... $8.9B Problem in Asthma  SALBUTAMOL (a.k.a. Albuterol) is the ONLY short-acting bronchodilator – several “me toos” - all act via same B-adrenergic pathway  $1.6B sales, 4th most prescribed, 15th highest selling GENERIC worldwide ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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