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mcolodny
mcolodny

... more mouths to feed than there were five years ago. Emboldened by the success of Amgen, Genentech and other early biotech pioneers, a wave of startups went public during the period from 1991 to 1994. This period was "a waterfall of money," one CEO nostalgically recalls. "You held out your cup and it ...
6. 7. 8. BRIEF RESUME OF THE INTENDED WORK ENCLOSURE
6. 7. 8. BRIEF RESUME OF THE INTENDED WORK ENCLOSURE

... aqueous solubility of poorly aqueous soluble drug molecules in the gastrointestinal fluid often causes unsatisfactory bioavailability. Poorly aqueous soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration of any drug to be absorbed must b ...
Genetic Algorithm on Twister
Genetic Algorithm on Twister

Please Take Out The Following: Pencil Science Journal Chapter 8
Please Take Out The Following: Pencil Science Journal Chapter 8

... Answer When alleles for different characteristics are on separate chromosomes, they are distributed to gametes separately. This is known as: The Law of Independent Assortment *Mendel's Law of Independent Assortment - The alleles of the many different genes present in any given (diploid) organism se ...
biological_approach.
biological_approach.

... amount of eggs she produces and the fact that she has to carry the baby for 9 months and then raise it till the age of 18. •Females therefore will be more particular about who fathers their children due to the investment they have to make. ...
H2 HomeFun Worksheet -Teacher`s Copy - CIA-Biology
H2 HomeFun Worksheet -Teacher`s Copy - CIA-Biology

... Date: _____________________ ...
The process of evaluating and regulating a new durg
The process of evaluating and regulating a new durg

... (mouse, rat, or guinea pig) and a nonrodent (cat, dog, or rabbit) are commonly used, since a drug’s effect on one species may be different from its effect on another.2,3 Although the FDA does not directly dictate this early laboratory and animal testing, it does have specific guidelines on the types ...
Moderate Sedation/ Analgesia (Conscious Sedation)
Moderate Sedation/ Analgesia (Conscious Sedation)

... Reflex withdrawal from a painful stimulus is NOT considered a purposeful response Sedation is a continuum, it is not always possible to predict how an individual will respond. Practitioners intending to produce a given level of sedation should be able to rescue patients whose level of sedation becom ...
Diagnostic Genetic Testing of a Potentially Affected Individual
Diagnostic Genetic Testing of a Potentially Affected Individual

... including but not limited to whole genome and whole exome sequencing, is considered investigational and not medically necessary unless all components of the panel have been determined to be medically necessary. However, individual components of a panel that meet the appropriate criteria may be consi ...
Genes, Inheritance and Genetic Testing
Genes, Inheritance and Genetic Testing

... This is a much faster test, as it involves looking for the presence or absence of the family gene alteration because the laboratory knows exactly which genetic alteration to look for and exactly which gene to test. This type of test can determine if a family member is likely to develop the same hear ...
CRISPR-Cas Gene Editing to Cure Serious Diseases: Treat the
CRISPR-Cas Gene Editing to Cure Serious Diseases: Treat the

... immediate need, for therapeutic purposes, in editing or correcting the DNA. It is also more appropriate to apply a new technology like CRISPR-Cas9 in the setting in which the consequences of the therapy are directed only to the patient and are not passed on to or altering the gene pool for future ge ...
Syllabus Fall 2016
Syllabus Fall 2016

OTC Drugs Monograph - Thai Self Medication Industry Association
OTC Drugs Monograph - Thai Self Medication Industry Association

...  Properly decided by the public on selection of indication, dose, compliance with dose, prevention of side effects, or treatment • Dosage forms that have high possibility of misuse and abuse, or of less or no safety and efficacy unless medical experts use are not acknowledge as OTC drugs.  When ap ...
OCULAR DRUG DELIVERY: TARGETING THE POSTERIOR
OCULAR DRUG DELIVERY: TARGETING THE POSTERIOR

... powered by iontophoresis, can transfer high drug concentrations across ocular tissues to the posterior segment.13 The BioSeizer platform is a lipid-based technology that can carry a therapeutic agent and enable significantly prolonged retention time at the target site, thereby reducing the frequency ...
response to member and stakeholder feedback
response to member and stakeholder feedback

... optometrists to using or prescribing oral CAIs, only in an emergency and where no physician is available, and immediate referral to a physician or hospital will continue as the standard of practice. Therefore, the proposed safeguards, with respect to oral CAIs, are not relaxed from the existing Desi ...
Inherited Arrhythmia Testing
Inherited Arrhythmia Testing

... Brugada syndrome (BrS) BrS occurs in approximately 1 in 5-10,000 individuals worldwide and is characterized by right precordial ST wave elevation on an EKG. Onset is typically during adulthood. A positive family history for sudden premature death and potentially lethal arrhythmias are also common. ...
PPG Meeting minutes Dec 2015
PPG Meeting minutes Dec 2015

... should now be seen to be coming from the PPG. This will be introduced as of January 2016. Text Messaging – It was suggested that we promote the service more. One suggestion was to ensure that it is on our advertisements in the local magazines. A leaflet in the repeat prescription bags. Reception to ...
narcolepsy medications
narcolepsy medications

... have many unpleasant side effects, including chronic dry mouth, which can lead to serious dental decay and loss of teeth. Newer anti-depressants have fewer and/or milder side effects, and have a more targeted action in the brain. Even among newer generation antidepressants, some have been found to h ...
June 29, 2011 For immediate release For more information, contact:
June 29, 2011 For immediate release For more information, contact:

... results in doses approximately 2.5 times higher than intended. In a recent case, a physician mistakenly ordered a dose of colistimethate as the prodrug, but the amount was dispensed as the colistin base. The patient developed complications including acute renal failure and later died. The alert prov ...
DrugRxn2011Im
DrugRxn2011Im

... • Serum sickness -- antihistamines, aspirin, and may use steroids to accelerate recovery via anti-inflammatory effects and increase clearance of immune complexes. ...
rajiv gandhi university of health sciences
rajiv gandhi university of health sciences

... their circulation time. Longer circulation of liposome in blood resulted in higher uptake of drug in an implanted tumor 6-8. Doxorubicin is an anticancerous agent used in breast cancer, ovarian cancer, AIDS related Kaposi’s sarcoma. The therapeutic efficacy of doxorubicin is restricted by dose limit ...
Subsequent Entry Biologics (SEBs) – Canada*
Subsequent Entry Biologics (SEBs) – Canada*

... • Released March 5, 2010: http://www.hcsc.gc.ca/dhp-mps/brgtherap/applicdemande/guides/seb-pbu/notice-avis_sebpbu_2010-eng.php • SEB approval: NDS with reduced data package • SEB sponsor to show a “demonstrated similarity” between the SEB and a suitable reference biologic drug • Well characterized p ...
Congenital & Genetic Disorders
Congenital & Genetic Disorders

... – Dominant allele = in large case; fully expressed – A dominant allele masks the expression of a recessive allele – Recessive allele = in small case; not expressed unless both alleles are recessive – True breeding (same as homozygous) – All offspring same as parent – The inheritance of identical all ...
highlights of prescribing information full prescribing
highlights of prescribing information full prescribing

... 6.2 Postmarketing Experience The following adverse reactions have been identified during post approval use of ACTIMMUNE. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relation ...
Source - Gilberto De Nucci
Source - Gilberto De Nucci

... (2838 [37.4%]). One-year incidence of PIM use was 42.1%. Incident PIM users were more likely to be hospitalized (odds ratio [OR] = 1.27; 95% CI, 1.10-C1.46) and more likely to die (OR = 1.46; 95% CI, 1.31-C1.62) in the 12 months after first receiving a PIM than nonusers, even after adjusting for dem ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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