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Agents Used in Cardiac Arrhythmias
Agents Used in Cardiac Arrhythmias

... ventricular arrhythmias, are uncommon with lidocaine use. In large doses, especially in patients with preexisting heart failure, lidocaine may cause hypotension—partly by depressing myocardial contractility. Lidocaine's most common adverse effects—like those of other local anesthetics—are neurologic ...
Cefadian - Avita Farma
Cefadian - Avita Farma

... (E171), hypromellose, talc, polyacrylate, ferric oxide (E172), cellulose powdered. Contra-indications None known. Interaction with other substances None known. ...
Document
Document

... Cystic fibrosis (CF) – CF is a genetic disease of the exocrine glands, usually developing during early childhood and affecting mainly the respiratory system, pancreas and sweat glands. It is characterized by the production of abnormally viscous mucus by the affected glands, usually resulting in chro ...
a review on: sustained release technology
a review on: sustained release technology

... retarded release and timed release medication. Over the past 30 years, as the expense and complication involved in marketing new entities have increased with concomitant recognition of the therapeutics advantages of controlled drug delivery, greater attention has been focused on development of susta ...
Genetic Testing
Genetic Testing

... Genetic testing usually involves taking a sample of blood or tissue. In adults and children this usually involves taking a blood sample from a vein. Some genetic tests can be done from samples of saliva or from taking a sample (swab) from the inside of your mouth. In pregnancy, a sample may be taken ...
Richard Bentall
Richard Bentall

... “Hesitated, responded with a question rather than with an answer, and smiled or laughed (when informal carers were present), indicating that they were reluctant to engage with patients' concerns about their psychotic symptoms”. ...
Principles of Drug Action
Principles of Drug Action

Drugs and driving don`t mix booklet
Drugs and driving don`t mix booklet

... ■ When two or more psychoactive drugs are used at the same time or on the same occasion. This includes alcohol, prescription and/or illicit drugs. ■ Often illicit drugs contain more than one drug. Drug manufacturers will do this to save money by using different cheaper chemicals, or to achieve a dif ...
Codeine Article-31 referral - EMA
Codeine Article-31 referral - EMA

... drowsiness, light-headedness, dizziness, sedation, shortness of breath, nausea, vomiting, and sweating, while serious adverse reactions include respiratory depression and, to a lesser degree, circulatory depression, respiratory arrest, shock, and cardiac arrest. It has been established that CYP2D6 i ...
DOXEPIN HCl Capsules Dear patient, Please read the following
DOXEPIN HCl Capsules Dear patient, Please read the following

... DOXEPIN HCl may be used to treat other conditions as well such as certain chronic and neuropathic pain and some types of headache. DOXEPIN has very potent antihistaminic activity. It has been shown to be an effective oral alternative to conventional antihistamines in the treatment of urticaria. The ...
Muscle Relaxants
Muscle Relaxants

... B. Sedatives (to calm and make patients unaware of their environment) C. Hypnotics (cause sleep/extreme sedation resulting in further CNS depression and sleep) II. Uses 1. Geriatric pts: comprise only 12% of our pop, but they consume 35-45% of the sedative-hypnotic drugs - for those in long-term car ...
Inappropriate Medications
Inappropriate Medications

... prescribed small doses of these medications. Total daily doses should rarely exceed the suggested maximum doses noted to the left. ...
Dosage Forms, Routes of Administration, and
Dosage Forms, Routes of Administration, and

... order medications for a human patient. Prescription orders are sometimes given Number of Refills Remaining to patients by their prescriber. A patient might then mail or hand-deliver a prescription to Figure 4.1   The essential components of a prescription. a pharmacy. Other times, prescriptions are ...
File
File

... - different genotypes and environmental influences result in different phenotypes that are acted on by natural selection ● Larger genomes = greater potential genetic diversity ● Greater number of different alleles = greater genetic diversity
 - sexual reproduction: recombination of parent alleles ● ...
Personalized treatment of heart failure with
Personalized treatment of heart failure with

... the 4 patients randomized to the B arm had diabetes, while only one patient in the UC arm had diabetes. All patients included in this case series had hypertension, and 2 and 3 patients in the B and UC arms had dyslipidemia, respectively. The demographic details and comorbidities are shown in Table 3 ...
Traditional medicine-inspired approaches to drug discovery: can
Traditional medicine-inspired approaches to drug discovery: can

... instance, Ayurvedic texts include thousands of single or polyherbal formulations [40]. These have been rationally designed and have been in therapeutic use for many years. Sufficient pharmacoepidemiological evidence, based on actual clinical use, can be generated to support their safety and efficacy ...
The Risk of Using Poppy Seed Tea Made from Several Varieties
The Risk of Using Poppy Seed Tea Made from Several Varieties

... worldwide because of the overdoses found in poppy seed tea. One of the cases found on the internet showed that the overdose appeared when using 1.5 kg of poppy seeds for obtaining the tea. Furthermore, it was an unexpected and undesired effect because the consumer had taken poppy seed tea several ti ...
Modeling Mendel*s Law
Modeling Mendel*s Law

... Relative greenness or brownness, blue eyes are recessive ...
Updating the Beers Criteria for Potentially Inappropriate Medication
Updating the Beers Criteria for Potentially Inappropriate Medication

... avoided in persons 65 years or older because they are either ineffective or they pose unnecessarily high risk for older persons and a safer alternative is available and (2) medications that should not be used in older persons known to have specific medical conditions. The 2 statements each used a 5- ...
Department of Pharmacology
Department of Pharmacology

... (doctor’s note, University’s letter, letter from other authorities, etc.)  Students with unjustified absences have to take the integrative test independent on their component tests (quizzes) results. Completion of the course of seminars (earning a credit):  Students’ progress shall be evaluated on ...
Chapter 14 Notes - Parkway C-2
Chapter 14 Notes - Parkway C-2

... Using Probability to Solve Genetics Problems 2. Rule of Addition (Either-or Rule) -Probability that an event will occur is the sum of the probabilities of each way that it can occur. -Useful when you want to know the probability of an event happening when there are several ways for the event to occ ...
SBI3C1: Genetics Test Review Part 1: Meiosis 1. Define the
SBI3C1: Genetics Test Review Part 1: Meiosis 1. Define the

... c. In humans, free earlobes (F) is dominant over attached earlobes (f). If one parent is homozygous dominant for free earlobes, while the other has attached earlobes can they produce any children with attached earlobes? d. In humans widow’s peak (W) is dominant over straight hairline (w). A heterozy ...
Draft Minutes of the Formulary Sub Group (FSG
Draft Minutes of the Formulary Sub Group (FSG

... Changing bisoprolol to first choice in Section 2.4 (Beta-adrenoceptor blocking drugs) will have cost implications, however figures have not been confirmed. Bisoprolol will be first choice wherever a beta-blocker is required in cardiovascular disease. Switching from atenolol to bisoprolol resolves si ...
Norry Tablet - Renata Limited
Norry Tablet - Renata Limited

... Adults : The optimum dosage and frequency of administration of bromazepam should be based on individual patient, the severity of symptoms and previous psychotic drug history. The usual dosage in general practice is from 3mg to 18mg daily in divided doses. In exceptional circumstances, in hospitalize ...
1 Croatian Institute for Brain Research, University of Zagreb
1 Croatian Institute for Brain Research, University of Zagreb

... tangles formation in the brain. Beside early diagnostics of AD, determination of CSF biomarkers is necessary for monitoring of potential treatments. Reduced levels of tand p-tau after treatment with tau-related therapeutics should indicate that a drug is working properly. Precisely, levels of p-tau ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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