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Profile of female patients seeking in-patient treatment for
Profile of female patients seeking in-patient treatment for

... psychoactive substance, reasons for initiation and cooccurring disorders have all been found to be different among men and women. Also, women are less likely to enter substance abuse treatment than men because of a variety of reasons8. Prescription opioid abuse has become a major clinical and publ ...
mandelian genetics - study
mandelian genetics - study

... a) What are the genotypes of his parents with respect to this trait? b) If Brandon’s sister married with a man with blood group AB, What is the percentage of their child having blood group B? ...
POLICY: (Arial, Bold, 12)
POLICY: (Arial, Bold, 12)

...  “High Alert Medication” means any medication that is deemed to possess higher risk of causing significant harm in a patient even if used as intended. Risk is increased if the agent is used in error (of any type), dosed inappropriately, requires stringent physiological monitoring for patient safety ...
Drug Release Profile of a Novel Biodegradable Antimicrobial Polymer
Drug Release Profile of a Novel Biodegradable Antimicrobial Polymer

... of free drug in the incubation solution, which might not be the true representation of the amount of free drug that was caused by the enzyme degradation. Some drugs in the incubation solution might have leached out from the matrices and contributed to the total drug amount. Therefore a large amount ...
1 - RCRMC Family Medicine Residency
1 - RCRMC Family Medicine Residency

... crossed over to the other condition. RESULTS: Eight out of 15 patients completed the entire study. The rest completed at least 2 weeks of study. Patients randomized to the BLT condition exhibited a statistically significant improvement in nocturnal sleep from a mean of 6.4 hours/night to 8.1 hours/n ...
Monograph  - Cancer Care Ontario
Monograph - Cancer Care Ontario

... national consensus body e.g. pan-Canadian Oncology Drug Review, pCODR).  Recommendation is based on an appropriately conducted phase III clinical trial relevant to the Canadian context OR (where phase III trials are not feasible) an appropriately sized phase II trial. Regimens where one or more drug ...
the Pressure Right® PONV (Post Operative Nausea
the Pressure Right® PONV (Post Operative Nausea

... Intervention For Nausea Control & More Pressure Right acupressure strips are USFDA 510(k) cleared to help surgery patients effectively deal with both early and delayed postoperative nausea and vomiting (PONV) symptoms. Its consistent anti-nausea effectiveness is continuous for up to 3 days. As a res ...
PRESENTATION FOR IMMEDIATE RELEASE
PRESENTATION FOR IMMEDIATE RELEASE

... • ImmunoXel with demonstrated unmatched performance in trials for the treatment of TB and AIDS • a fully developed Drug Delivery Platform with unprecedented potential • the IP for a future obesity drug and: ...
genetics - cloudfront.net
genetics - cloudfront.net

... Hybrids – offspring of truebreeding plants Tall x Short = Hybrid ...
The Degree of Oneness
The Degree of Oneness

... dominance in operation was described by [Pai 85] using four o'clock flowers. She described how, if one was to mate two of these flowers, one red and the other white, all of the offspring would be pink flowers. On the other hand, if one were to mate two pink flowers, the resulting offspring would be ...
Therapy of Inflammatory Bowel Disease: What to Expect in the Next
Therapy of Inflammatory Bowel Disease: What to Expect in the Next

... success rates of 80 and 91%, with cohorts of 10 and 24 patients, respectively.[43,44] In the only randomized controlled trial investigating autologous stem cell transplant, 45 patients with severe Crohn's disease were randomized to receive either cytotoxic conditioning followed by autologous cell i ...
Basic Concepts in Medicinal Chemistry - Review
Basic Concepts in Medicinal Chemistry - Review

... Chapter 5 transitions the student into applying understanding of functional groups and pKa to the topic of salts and solubility. There is a thorough coverage of both organic and inorganic salts, the former of which is not always discussed extensively in other textbooks. The authors use a presentatio ...
Clinical Pharmacology of Antiretroviral Therapy
Clinical Pharmacology of Antiretroviral Therapy

... months ago, during a hospitalization with CNS toxoplasmosis. He is currently receiving treatment for toxoplasmosis and has tolerated his medication over the past two months  At diagnosis he had significant lower leg numbness and weakness due to INH therapy for TB  Pyridoxine 40 mg was started to r ...
LECTURE OUTLINE
LECTURE OUTLINE

... Polygenic inheritance occurs when a trait is governed by two or more sets of alleles. These often result in a continuous variation of phenotypes. Skin Color Skin color is an example of a polygenic trait that is likely controlled by many pairs of alleles. 23.3 Environmental Influences Environmental f ...
Drugs for Neurodegenerative Diseases
Drugs for Neurodegenerative Diseases

... (All are related to activation of central and peripheral D2 receptors) • Reduction of plasma prolactin levels (within hours from administration). • Stimulation of GH release in normal subjects but blockade (for unknown reasons) of release in acromegalic subjects. Pharmacokinetics and administration ...
garland3e_ppt_ch14 - York College Course and Testing System
garland3e_ppt_ch14 - York College Course and Testing System

... – Determines when driver is legally drunk • Almost uniform at 0.08% across country • Maine: 0.05% for drivers with previous DUI • New York: commercial drivers at 0.04% ...
The management of co-morbidities in patients with heart failure
The management of co-morbidities in patients with heart failure

... and pulse pressure levels were associated with higher rates of adverse events. [3] ...
Side effects
Side effects

... Of the three natural xanthenes agents, theophylline is most selective in its smooth muscle effect, while caffeine has the most marked central effect. ...
Mutationism, Neutralism, Selectionism
Mutationism, Neutralism, Selectionism

... Gene substitution is the end result of an adaptive process whereby a new allele takes over future generations of the population if and only if it improves the fitness of the organism. Polymorphism is maintained when the coexistence of two or more alleles at a locus is advantageous for the organism o ...
Partial Seizures - My Illinois State
Partial Seizures - My Illinois State

...  MAO inhibitors  inhibit metabolism  hypertensive crisis  Pyridoxine (vitamin B6)  promotes levodopa breakdown  reversal of levodopa effects (carbidopa may prevent this) o Avoid taking vitamin B6 supplements and eating vitamin-fortified foods o Take with juice and low-protein snack or after me ...
ketorolac tromethamine utilization management criteria
ketorolac tromethamine utilization management criteria

... intraoperatively when hemostasis is critical because of increased risk of bleeding. RATIONALE: This medication carries risk of serious adverse effects. Inappropriate use (such as dosing beyond label recommendations) will not provide better efficacy, but will result in increasing the risk of adverse ...
August Salvia Abuse
August Salvia Abuse

... Jon Daily, LCSW, CADC II ...
Agents Used in Cardiac Arrhythmias
Agents Used in Cardiac Arrhythmias

... ventricular arrhythmias, are uncommon with lidocaine use. In large doses, especially in patients with preexisting heart failure, lidocaine may cause hypotension—partly by depressing myocardial contractility. Lidocaine's most common adverse effects—like those of other local anesthetics—are neurologic ...
Two New Mild Homozygous Mutations in Gaucher Disease Patients
Two New Mild Homozygous Mutations in Gaucher Disease Patients

... Gaucher disease (GD) is a lysosomal glycolipid storage disorder characterized by the accumulation of glucosylceramide mainly in macrophages. It is common among Ashkenazi Jews [Beutler and Grabowski, 1995]. There are 3 clinical types of GD: type 1, characterized by hepatosplenomegaly, anemia, thrombo ...
Medicines Management Programme
Medicines Management Programme

... of literature.13 Systematic reviews and meta-analyses utilise pooled data from clinical trials and provide an additional means of assessing the general and comparative efficacy of drugs for UI, urinary frequency and OAB. A strength of the meta-analytic technique is that it provides an overall perspe ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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