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annexure-ii
annexure-ii

... and delayed ischemia onset without significantly modifying heart rate, blood pressure or both4.Because of its high solubility, short half life(6±1.4 hrs)5 and therapeutic use in chronic disease it is considered as an ideal drug candidate for the design of oral controlled release dosage form. The use ...
Mendelian Genetics - Nicholls State University
Mendelian Genetics - Nicholls State University

... designated with a + superscript. Any other form is called a “mutant” The gene is named with an abbreviation of the mutant name. If the mutant is recessive a lower case abbreviation is used and the wild-type allele is given a + superscript. Example: vestigial wings is a recessive mutant. The mutant a ...
Mendelian Genetics - Nicholls State University
Mendelian Genetics - Nicholls State University

... designated with a + superscript. Any other form is called a “mutant” The gene is named with an abbreviation of the mutant name. If the mutant is recessive a lower case abbreviation is used and the wild-type allele is given a + superscript. Example: vestigial wings is a recessive mutant. The mutant a ...
1 Scope and Impact of Financial Conflicts of
1 Scope and Impact of Financial Conflicts of

... 43% of investigators also receive research-related gifts, including biomaterials and funding. One third of investigators at academic institutions have personal financial ties with drug industry sponsors. 37% of investigators in the National Academy of Sciences have “dual affiliations” with both univ ...
Here - Mainely Science
Here - Mainely Science

... he would see in their offspring  6) Mendel made 3 conclusions (2 of which were part of his Law of Segregation). What  was his first conclusion not including the Law of Segregation.? ​ ...
End of Life Care - RCRMC Family Medicine Residency
End of Life Care - RCRMC Family Medicine Residency

... Questions and answers: why does POLST form have full resuscitation option? allows patient to specify wishes for other measures, eg, AHN also, documentation of wish for resuscitation on POLST form indicates that patient has discussed their wishes for this option can duration of hospice exceed 6 mo? y ...
Name: Date: Teacher: Class/Period: 1)
Name: Date: Teacher: Class/Period: 1)

... Date: Class/Period: ...
edarbi - Takeda
edarbi - Takeda

... Edarbi is an angiotensin II receptor blocker (ARB) indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled tria ...
GLIS3%20paper%20Dimitri%20JCEM%20Final.
GLIS3%20paper%20Dimitri%20JCEM%20Final.

... 7.5-kb transcript is strongly expressed in pancreas, thyroid and kidney with smaller transcripts predominantly expressed in liver, kidney, heart and skeletal muscle 8. Thus mutations in GLIS3 have the potential to cause widespread disruption. Previously described severely affected individuals with m ...
Therapy of hypertension
Therapy of hypertension

A gene dosage map of Chromosome 18
A gene dosage map of Chromosome 18

... region contains 21 genes of which only one gene (PMP22) is associated with both phenotypes.9 The other 20 genes in the region do not produce a phenotype when hemizygous or when duplicated and therefore would be classified as haplosufficient. We hypothesize that most genes on Chromosome 18 are actual ...
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... opioid drugs. Tolerance and dependence are physiological responses seen in all patients and are not predictors of abuse. For example, cancer pain often requires prolonged treatment with high doses of opioids, leading to tolerance and dependence. Yet, abuse in this setting is very unusual. Neither th ...
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What is Health Psychology?

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Enrofloxacin is a synthetic, broad spectrum antimicrobial substance
Enrofloxacin is a synthetic, broad spectrum antimicrobial substance

... Normal sterile precautions should be taken. The safety of the product has not been established in calves when administered by the intravenous route and use of this route of administration in calves is therefore not recommended. Official and local antimicrobial policies should be taken into account w ...
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... unbound fraction of thiopentone is the active part, therefore if less bound, more active… So one must decrease the dose. Excretion: small percentage excreted unchanged in the kidneys. ...
Stroke and AF - West Suffolk Clinical Commissioning Group
Stroke and AF - West Suffolk Clinical Commissioning Group

... 1.2 The decision about whether to start treatment with Dabigatran etexilate should be made after an informed discussion between the clinician and the person about the risks and benefits of Dabigatran etexilate compared with Warfarin. For people who are taking Warfarin, the potential risks and benefi ...
Unit 6 Genetics and Heredity
Unit 6 Genetics and Heredity

... – ____: Poor soil or drought may produce shorter (or no) ears – _______ seedlings: Green (dominant) & albino (recessive)… • however green color is also affected by environment – No sunlight green color cannot be expressed due to lack of chlorophyll production – Put in light green will appear b/c chl ...
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Document

... effect of each allele, hence additive. • Additive alleles are not affected by the presence of other alleles. • The effect of additive alleles allow biologists to follow evolution in a predictable way. ...
There are a variety of diseases commonly ascribed to antigenic
There are a variety of diseases commonly ascribed to antigenic

... Essentially, genomic/proteomic analysis of potential risks for cerebral hemorrhaging and other disorders like it is a relatively new development, but one with a great deal of promise. Stroke itself does not require a genetic component but, like obesity, understanding the hereditary aspects of stroke ...
Genetic Associations of Obesity: The Fat-Mass and Obesity
Genetic Associations of Obesity: The Fat-Mass and Obesity

... end of 24 months. Beyond this, however, the groups began to diverge, with the patients with at least one risk allele having increased body weight and BMI at 36, 48, and 60 months following surgery compared with the TT patients. BMI was 5, 15, and 20% higher at these time points. The implications of ...
Stephen F. Austin State University DeWitt School of Nursing
Stephen F. Austin State University DeWitt School of Nursing

... academic or other penalties. The prohibition applies to all instructional forums, including electronic, classroom, labs, discussion groups, field trips, etc. The instructor shall have full discretion over what behavior is appropriate/inappropriate in the classroom. Students who do not attend class r ...


... ScriptSwitch has now been running in 29 out of the 34 practices in NHS Dumfries and Galloway since November 2013. The graph below shows the variation in its use amongst practices. The dark dots within the bars represent actual savings made against the potential savings. There are obviously practices ...
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Genetic Notation Overview Phenotype Naming

... Common Names (Koi, Clown, Paraiba, etc) ...
azaCITIDine - Cancer Care Ontario
azaCITIDine - Cancer Care Ontario

... information (for health professionals) contained in the Drug Formulary (the "Formulary") is intended for healthcare providers and is to be used for informational purposes only. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects o ...
Full Lecture 9 - Institute for Behavioral Genetics
Full Lecture 9 - Institute for Behavioral Genetics

... - a population of animals produced by mating related individuals together for many generations in mice : 20 generations (5 years) brother/sister, ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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