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Access to Quality Medicines: Rajasthan Model
Access to Quality Medicines: Rajasthan Model

... for All”, good quality healthcare is a basic fundamental right of people and should be made available to all. In all advances in medical sciences, medicines have remained the core in the healthcare and would continue to be the core; thereby it implies that access to essential medicines is also a bas ...
Law, Policy, and Market Implications of Genetic Profiling in Drug Development
Law, Policy, and Market Implications of Genetic Profiling in Drug Development

... challenges resulting from allocation of higher research and development (“R&D”) costs to smaller patient groups; 19 o Pharmaceutical efforts to reach presently untapped markets and to introduce preventive drug use to offset market losses attributable to the fracturing of traditional patient groups ( ...
Discovering Novel Adverse Drug Events Using Natural
Discovering Novel Adverse Drug Events Using Natural

... • *Expense from ADEs is $5.6 billion annually • *Estimated that over 2 million patients hospitalized due to ADEs • *ADEs are fourth leading cause of death *In US alone ...
informed consent form
informed consent form

... If you are dependent of opiates – any opiates – you should be in as much withdrawal as possible when you take the first dose of buprenorphine. The first dose of buprenorphine will be given to you at the office under supervision. If you are not in withdrawal, buprenorphine can cause severe opiate wit ...
this presentation as a tool to present at your town library
this presentation as a tool to present at your town library

... I will give you Daubert competent science. Science that has passes 6 Daubert Hearings. Scientific (as opposed to opinion) evidence is the only kind of expert evidence admissible in American and Australian courts Scientific evidence that SSRIs cause: ...
BRIEF RESUME OF THE INTENDED WORK: Need for the study
BRIEF RESUME OF THE INTENDED WORK: Need for the study

... Valiollah et al. (2011) in an animal model involving formalin test showed that Glibenclamide (ATP sensitive potassium channel blocker) could suppress the antinociceptive effect of Amitriptyline and Fluvoxamine either partially or completely. 4 A comparative study done in diabetic neuropathy animal m ...
ADVANCE IN TREATMENT OF TYPE 2 D.M.
ADVANCE IN TREATMENT OF TYPE 2 D.M.

... Animal data suggest that these drugs prevent beta-cell apoptosis and may in time restore beta-cell mass. The latter property, if proven in humans, would have tremendous therapeutic potential. ...
Why pediatric dosing errors happen & how to avoid them
Why pediatric dosing errors happen & how to avoid them

... leaders acknowledged that these high-stress situations can impair the provider’s cognitive processing skills.13 They reasoned that the only solution may be to standardize drug concentrations and develop charts for the prehospital environment. In 2012 a large study at the University of Michigan revie ...
Antiepileptic Drug Selection for People with HIV/AIDS
Antiepileptic Drug Selection for People with HIV/AIDS

... In addition, weak evidence shows enzyme-inducing seizure drugs (EI-AEDs) also may lower blood levels of some types of HIV/AIDS drugs. EI-AEDs make certain liver enzymes more active. People taking these drugs may develop drug resistance, and their disease may get worse. They also may pass on the dise ...
Genome-Wide Prediction of Functional Gene
Genome-Wide Prediction of Functional Gene

... identify potential epistatic interactions by looking for co-adapted genes marked by excess two-locus genetic differentiation between populations/lineages using publicly available SNP genotype data. The practical motivation for this effort is to reduce the number of pair-wise tests that need to be pe ...
April 4th 4285 - Scheid Signalling Lab @ York University
April 4th 4285 - Scheid Signalling Lab @ York University

... Tests based on DNA, RNA, chromosomes, protein Testing parents for carrier status Prenatal testing Neonatal testing Testing in children Presymptomatic screening for late-onset disease Presymptomatic screening for complex disease susceptibility ...
Antipsychotic Policy - Portsmouth Hospitals NHS Trust
Antipsychotic Policy - Portsmouth Hospitals NHS Trust

... Guidelines for those people over sixty five being admitted on antipsychotics For those aged over 65 admitted on antipsychotic medication, ensure the following is achieved. 1) Ascertain the diagnosis and reason for antipsychotics. 2) Additional information should be gathered from the GP including wh ...
Genetic Enhancement
Genetic Enhancement

... 5. Other Objections to Genetic Enhancement: Other worries below. (1) Unexpected Side-Effects: Our genes are often linked in certain important ways, such that enhancing one gene might have radical negative side-effects for some other gene. For instance, in Africa, there is an uncommonly high number o ...
Genetic Transfer PPT
Genetic Transfer PPT

... the accuracy of the EPDs, and who estimated the EPDs. A high EPD is not necessarily good; it depends on the trait being considered and breeding objectives. ...
1 Objectives Diuretic Agents 1. Review the physiology of sodium
1 Objectives Diuretic Agents 1. Review the physiology of sodium

... Identify contraindications for the use of antihypertensive drugs. Identify commonly occurring adverse drug effects for the major classes of antihypertensive drugs. Discuss the therapeutic management of hypertensive emergencies and urgencies. Understand the therapeutic approach to the management of h ...
MAXALT® MAXALT-MLT™
MAXALT® MAXALT-MLT™

... Paroxetine: In a study of the interaction between the selective serotonin reuptake inhibitor (SSRI) paroxetine 20 mg/day for two weeks and a single dose of MAXALT 10 mg in healthy subjects (n=12), neither the plasma concentrations of rizatriptan nor its safety profile were affected by paroxetine. Or ...
PowerPoint Chapter 5
PowerPoint Chapter 5

... to pediatric, pregnant, breastfeeding, or elderly patients  Identify special considerations for providing care to ...
HYPERTENSION ABC & Update
HYPERTENSION ABC & Update

... Tell patient BP reading and provide a written copy Come to agreement with the patient on goal BP Ask patient to rate (1 to 10) his or her chance of staying on treatment Inform patient about recommended treatment and provide specific written information about the role of lifestyle, including diet, ph ...
substance abuse drugs - University of the Sciences in Philadelphia
substance abuse drugs - University of the Sciences in Philadelphia

... Uneasiness & anxiety Thirst & hunger Smoke can affect breathing ...
Toxicity and safety of medicinal plants
Toxicity and safety of medicinal plants

... to misleading results - one of the commonest mistakes being the failure to verify the actual identity of plant material used in their experiments, let alone the detection of contaminants! These points beg the question of what paradigm can be used for research into the safety and efficacy of herbal t ...
A new trend in drugs-of-abuse
A new trend in drugs-of-abuse

... Five different products were identified as being of interest and purchased subsequently (Table 2). All of these products were available in the central region, while some of them were only obtainable elsewhere. Every product consisted of tablets and contained a synthetic substance. Four different sub ...
Chapter Two Theories - Dimensions Family Therapy
Chapter Two Theories - Dimensions Family Therapy

... the 23 pairs of chromosomes duplicate, forming two complete sets of the genetic code for that person (zygote) these two pair sets move toward the opposite sides of the zygote and the single cell in the zygote splits down the middle the zygote’s outer membrane surrounds two cells, each containing a c ...
Center for Drug Evaluation and Research
Center for Drug Evaluation and Research

... *For prostate cancer, data are for men only, and for breast cancer data are for women only. †For non-serious adverse events and details, see table 7 and text. ‡For non-serious adverse events, see text. ...
Depression Support Resources: Telephonic/Care
Depression Support Resources: Telephonic/Care

...  Explore what they think having depression means and dispel some of the myths.  If patient insists that they are not depressed, focus more on their symptoms.  For example, if their main symptom is insomnia, suggest that the medication they have been prescribed will help to relieve that symptom. B ...
Chemical or crazy?
Chemical or crazy?

... amount required to produce an effect of given intensity. A highly potent drug evokes a larger response at low concentrations. It is proportional to Affinity and Efficacy • For our purposes, how strong the stuff is……don’t forget synergistic effect and contaminants ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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