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A de novo 16q24 - HAL
A de novo 16q24 - HAL

... palpebral fissures and umbilical hernia [8-10]. Involvement of the 16q24 band causes similar characteristics, suggesting that some symptoms, such as developmental delay, cardiac defects, small palpebral fissures, periorbital edema, hypotonia, long fingers, recurrent infections, epicanthal folds bro ...
New priorities emerge from devastating earthquake, tsunami
New priorities emerge from devastating earthquake, tsunami

... • M&A activity driven by the need to build R&D organization (early- and late-stage) will remain important. • If power outages and transportation delays remain persistent, clinical trials could suffer. Companies will be looking for better project management and R&D outsourcing opportunities. • Medica ...
Plaquenil 200mg Film-coated Tablets
Plaquenil 200mg Film-coated Tablets

... Small children are particularly sensitive to the toxic effects of 4-aminoquinolines; therefore patients should be warned to keep Plaquenil out of the reach of children. All patients on long-term therapy should undergo periodic examination of skeletal muscle function and tendon reflexes. If weakness ...
Improving efficiencies in the self-medication
Improving efficiencies in the self-medication

... with chronic diseases, has implemented a self-medication program (SMP) to teach patients to manage their medications on their own [1]. This programme also helps patients better understand what medications they are taking to prevent taking the wrong medication. This case study examines the SMP in the ...
Slide 1
Slide 1

... contribute to this association4. Genetic studies in several populations have identified a region on chromosome 5q31-q33 that contains the asthma susceptibility gene in several populations5,6,7,8. This region contains a cluster of pro-inflammatory cytokines genes that play an important role in immune ...
15. Annie Smartt - California Cornflakes and Brown Sugar: The Genetic Predisposition to Heroin and Cocaine Addiction
15. Annie Smartt - California Cornflakes and Brown Sugar: The Genetic Predisposition to Heroin and Cocaine Addiction

... stigma. Epidemiological studies show that around 40-60% of the risk of developing an addiction to heroin is genetically determined (Kreek, M.J. et al. 2005). Despite the complexity of these phenotypes, genome-wide association studies along with candidate gene case-control association studies have id ...
SAFETY AND EFFICACY OF SIX-MONTH OUTPATIENT INTERMITTENT NESIRITIDE INFUSIONS Research Article
SAFETY AND EFFICACY OF SIX-MONTH OUTPATIENT INTERMITTENT NESIRITIDE INFUSIONS Research Article

... an outpatient disease management setting seems to be a plausible approach likely to be clinically effective. This study was limited by its open-label design, the relatively small number of patients studied, the absence of a comparable group, and absence of long term follow up. Two meta-analyses have ...
Advanced Psychopharmacology: AACAP Meeting Oct.18
Advanced Psychopharmacology: AACAP Meeting Oct.18

... Reduce dose to 0.5 mg/kg/d if using known inhibitors of p448 (e.g. paroxetine, fluoxetine, ...
ST elevation
ST elevation

...  The evidence supporting the benefit of beta blockers has been obtained primarily from randomized trials that included predominantly patients with ST-elevation MI (STEMI).  Randomized trials performed before the use of reperfusion therapy with either fibrinolysis or PCI consistently showed a reduc ...
Suggestion from clinicians
Suggestion from clinicians

... Hydrochlorothiazide in its usual dose of 12.5 to 25 mg per day has never been shown to reduce the risk of myocardial infarction, stroke, or death.4 In fact, higher doses have been shown to increase the risk of sudden cardiac death in a dose-dependent fashion.8 3. Even in combination with an angioten ...
Diabetes handout - City Tech OpenLab
Diabetes handout - City Tech OpenLab

... MOA: decrease the amount of glucose released from liver. It is usually taken 1-2 times per day with breakfast and an evening meal. *Glucophage (metformin) Take with food to minimize the following symptoms: Diarrhea, nausea/vomiting, flatulence (gas), bloating 4. Thiazolidinediones MOA: Make the body ...
Leslie Clark Fact Sheet: Sedative Hypnotics Definition/Description of
Leslie Clark Fact Sheet: Sedative Hypnotics Definition/Description of

... `In clinical therapeutics, sedative-hypnotics are useful for treatment of a variety of diseases related to the central nervous system, such as acute and chronic anxiety, anesthesia, seizure control, and insomnia. Sedative-hypnotic drugs have a sedative, calming, and anxiolytic effect on patients, es ...
NAME_______________________________ EXAM
NAME_______________________________ EXAM

... 6. (14 points) Provide short answers to the following questions. a. (6 points) For the diseases phenylketonuria and scurvy, discuss the importance of genetic and environmental factors in (1) causing the disease phenotype in individual people and (2) causing phenotypic variation at the population lev ...
THOMAS A
THOMAS A

... TB: My residency was cut short because I was promoted from the first to fourth year and in 1959 I became the junior member of Cameron’s research team on “psychic driving”. Ewen Cameron was chairman of psychiatry at McGill. He was one of the Nurembergpsychiatrists and a past president of the American ...
Benzydamine Abuse as a Hallucinogen
Benzydamine Abuse as a Hallucinogen

... action such as the agonistic activation of 5HT2A receptors. It is known that several indole groups, such as diethylamine in lysergic acid and dimethyltryptamine, cause hallucinations based on this mechanism ( 5,6,11). According to the data obtained from epidemiological studies carried out in Brazi ...
FORMULATION AND EVALUATION OF GUAR GUM BASED COLON TARGETED TABLETS... SECNIDAZOLE AND ITS β-CYCLODEXTRIN COMPLEX TO TREAT AMOEBIASIS
FORMULATION AND EVALUATION OF GUAR GUM BASED COLON TARGETED TABLETS... SECNIDAZOLE AND ITS β-CYCLODEXTRIN COMPLEX TO TREAT AMOEBIASIS

... From the last few decades, a great deal of research work has been devoted to the development of the site specific drug delivery systems which offer several benefits over the traditional drug therapies. The therapeutic advantages of targeting the drug to the diseased organ include delivery of the dru ...
Comprehensive Genetic Testing
Comprehensive Genetic Testing

... and commitment to excellence in testing, as well as a longstanding dedication to innovation. We continue to be a leader in diagnostic solutions by offering options that fit to your patient: single genes testing, multi-gene panels of varying sizes, reflex/tiered panels, and whole exome sequencing. Co ...
2013 Sep Vivas - Notes For ANZCA Primary Exam
2013 Sep Vivas - Notes For ANZCA Primary Exam

... by this blood gas? What would be the bicarbonate in this blood gas? Is this patient on supplemental oxygen? How can you tell? The alveolar gas equation Can you write it please and I will add some values... Affects of CO2 on the CNS in general (not just CBF). fatigue, confusion, dizziness, blurred vi ...
Biology 12
Biology 12

... Epigenetics is the study of epigenetic inheritance, a set of reversible inheritable changes in gene function or other cell phenotype that occur without any changes in DNA sequence (genotype). These changes may occur spontaneously; in response to environmental factors; or in response to the presence ...
Incomplete Penetrance
Incomplete Penetrance

... • Their diet is essentially phenylalanine-free ...
[acute trust logo] - Coastal West Sussex Formulary
[acute trust logo] - Coastal West Sussex Formulary

... Stimulants should be used with caution in patients with history of tics, Tourette’s syndrome and porphyria. In psychotic children, stimulants may exacerbate behavioural disturbances and thought disorder. Treatment emergent psychotic or manic symptoms, e.g. hallucinations, delusional thinking or mani ...
1083 good distribution practices—supply chain integrity
1083 good distribution practices—supply chain integrity

... All forms of medicine, including those that purport or appear to be branded, generic, over-thecounter, or biologic drugs, in tablet, injectable, or other dosage forms, are under threat of being counterfeit or substandard, The most common motive for producing a counterfeit drug product is commercial ...
Drugs for Neoplasia
Drugs for Neoplasia

... • A Port-a-Cath has been placed to his right upper chest. The nurse asks him if he is feeling depressed. She provides support and active listening as he shares his concerns. The nurse contacts his brother at his request. As the nurse leaves the room, Mr. C. smiles and says, “I’ll be fine.” ...
An Update on Analgesics for the Management of Acute
An Update on Analgesics for the Management of Acute

... it irreversibly damages cyclooxygenase for the life of the platelet; if doses are high, one could consider withdrawing ASA for at least one week before surgery. ASA is more commonly used for prophylaxis of myocardial infarction and is usually taken in a low dose — no more than 325 mg per day. Indivi ...
Respiratory Care Pharmacology
Respiratory Care Pharmacology

... Respiratory Care Pharmacology  Application of pharmacology to the treatment of ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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