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Suggestion from a pharmaceutical company
Suggestion from a pharmaceutical company

... one agent over another. Indirect comparisons using appropriate statistical methods have been performed but their limitations have to be acknowledged.20,21 Differences in baseline populations and in the designs of the key RCTs affect the ability to make any definitive comparisons between the NOACs. A ...
safety - Moodle Lille 2
safety - Moodle Lille 2

...  More frequent monitoring due to higher rates of urogenital AEs among dapagliflozin patients  Event rates for males observed in the active treatment arms significantly exceeded the rates expected in an age-matched reference diabetic population.  “Dr. Hampp points out that the limitations of these ...
CH24 Page 1-5
CH24 Page 1-5

... TIA, transient ischemic attack; AF, atrial fibrillation; HTN, hypertension; DM, diabetes mellitus; CHF, chronic heart failure; mo, months; RF, risk factor; VTE, venous thromboembolism. a The 2012 Chest guidelines specify “recent” stroke or TIA as having occurred within the past 6 months. b A recent ...
The benefits of performing studies in fresh human tissue -De
The benefits of performing studies in fresh human tissue -De

... drug candidates. Cell lines are, however, a contrived experimental system and one should be cognizant of the risks in extrapolating the properties of a compound in these systems relative to that in the native human setting. This is particularly true for receptor agonists where the potency of a molec ...
Test Info Sheet
Test Info Sheet

... Sequencing of the ITGB4, ITGA6, and PLEC1 genes are offered as separate tests, usually performed in sequential order, starting with ITGB4. Using genomic DNA obtained from the submitted biological material, bidirectional sequence of the coding region and splice junctions of the ITGB4 gene (41 coding ...
Mendel and Genetics
Mendel and Genetics

... Phenotype – The physical appearance or characteristic. (i.e. brown eyes, constricted pods, red flowers, ability to make lactose, normal.) Genotype – Gene combination. Two genes (alleles) for constricted pods, heterozygous, homozygous recessive, RR, Rr, rr. ...
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Presentation

... Ashwin Shah ...
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View Slides

... trauma, morbid obesity, or unstable cervical spine injuries  Benzodiazepines, combined with opioids, are commonly used during AFOI – However, these agents can cause respiratory depression, in addition to the desired sedation, increasing the risk for hypoxemia and aspiration ...
Math 31S. Rumbos Fall 2011 1 Solutions to Assignment #1 1. Let f
Math 31S. Rumbos Fall 2011 1 Solutions to Assignment #1 1. Let f

Investor Presentation
Investor Presentation

... could cause actual results to differ materially from expected results, performance or achievements expressed or implied by statements made herein. Our actual results could differ materially from those anticipated in forward-looking statements for many reasons, including, but not limited to, uncertai ...
Chapter 9 - Genetics
Chapter 9 - Genetics

... • Mendel’s strong background in mathematics (and physics and chemistry…) served him well in his studies of inheritance • He knew he needed large sample sizes • The laws of inheritance reflect the probability of an event occurring – The probability of having a girl: 1 in 2 – The probability of rollin ...
Chapter 9 Genetics
Chapter 9 Genetics

... a. dangerously high levels of cholesterol occur in the blood and b. heterozygotes have intermediately high cholesterol levels. B. 9.12 Many genes have more than two alleles in the population 1. Although each individual carries, at most, two different alleles for a particular gene, in cases of multip ...
Metabolic disease resources - Zurich Open Repository and Archive
Metabolic disease resources - Zurich Open Repository and Archive

... that focuses on small molecule pathways in humans. SMPDB includes metabolic, disease, metabolic signaling and drug action pathways. In all these pathways, locations of reactions, from the organ to the subcellular level, are indicated. Nonmetabolite pathway components such as proteins, are hyperlinke ...
Mode of Inheritance
Mode of Inheritance

... Some Disorders Are X-Linked A. Color Blindness  Three types of cones are in the retina: those that detect red, those that detect green, and those that detect blue. Genes for blue cones are autosomal; those for red and green cones are on the X ...
ARA Prescriber`s Information on Medications for Rheumatic
ARA Prescriber`s Information on Medications for Rheumatic

... Category A: Drugs which have been taken by a large number of pregnant women and women of childbearing age, without any proven increase in the frequency of malformations or other direct or indirect harmful effects on the foetus having been observed. Category B1: Drugs which have been taken by only a ...
narcotic analgesics - Kamala Nehru Polytechnic (Pharmacy)
narcotic analgesics - Kamala Nehru Polytechnic (Pharmacy)

... death.Death is due to respiratory depression. Treatment: Two major lines of treatment are the administration of specific antagonist ; Naloxone and Gastric lavage. Naloxone 0.4 mg IV repeated every 2-3 minutes till narcotic reversal is achieved . Gastric lavage is useful to wash out ingested drug and ...
Magnevist Pi submitted with 100 mL application
Magnevist Pi submitted with 100 mL application

... weight gain and food consumption and a decrease in the mean weights of testis and epididymis occurred in male rats at the 2.5 mmol/kg dose. In a separate experiment, 16 daily intravenous injections were administered to male rats. At a dose of 5 mmol/kg of dimeglumine gadopentetate, spermatogenic ce ...
PATIENT REPORT Patient: Medical Record/Patient #:
PATIENT REPORT Patient: Medical Record/Patient #:

... clinical studies involving patient populations with specific clinical features as noted in section titled Clinical Experience. These results have not been validated in patients with clinical features different from those described. The discriminant value relates to Class 1 vs 2. See page 2 of initia ...
VOL 17 NO3 Jul-Sept 2010 - The Pharmaceutical Society of Hong
VOL 17 NO3 Jul-Sept 2010 - The Pharmaceutical Society of Hong

... hormone. Investigation revealed that the woman joined a weight reduction course organised by Fit Beauty in Fanling. She was advised to take two capsules of the product every day. The proprietor was arrested and a total of 28 bottles of the product were seized, after a search at the company. In Hong ...
Anti-amebiasis Drugs
Anti-amebiasis Drugs

... cure of P vivax and P ovale, because chloroquine does not eliminate dormant liver forms of these species. 2- Chemoprophylaxis: for without resistant falciparum malaria in malarious regions. 3- Amebic liver abscess: not effective in the treatment of intestinal or other extrahepatic amebiasis. Adverse ...
Med Chem II Tutoring
Med Chem II Tutoring

... WHAT IS THE DOC FOR ABSENCE SEIZURES? • A. methsuximide • B. phenytoin ...
02 02
02 02

... emotional or physical stress, fright or the ‘fight or flight’ response. They are part nervous system ...
treatment of severe sleep disorder related to alcohol
treatment of severe sleep disorder related to alcohol

... agonist for the MT1 and MT2 receptors and a 5-HT2C antagonist, representing a new class of antidepressants. It has been approved for the treatment of adults with major depression (de Bodinat et al. 2010). The recommended dose-range of agomelatine for this indication is 25-50 mg/day. However, early p ...
Information for Residential Care Staff Handling Cytotoxic Drugs
Information for Residential Care Staff Handling Cytotoxic Drugs

... Handling Cytotoxic Drugs ...
File
File

... • Family tree genetic diagrams are used by doctors to provide genetic counselling for couples with genetic disorders prior to pregnancy. Q. Explain why they are useful and what ethical considerations such counselling might raise. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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