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Bez nadpisu - Dr.Fatimah Al.Shehri
Bez nadpisu - Dr.Fatimah Al.Shehri

... • killing effect is best predicted by the percentage of time – that blood concentrations of a drug remain above the MIC. – increasing the concentration of ATB to higher multiples of the MIC does not significantly increase the rate of kill – E.g., for PNC and cephalosporins, dosing schedules that ens ...
Mendel`s
Mendel`s

... Mendel placed great emphasis on organizing his results in terms of ratios. It is good to be familiar with the basic genotype and phenotype ratios that are observed in monohybrid and dihybrid crosses of traits that display complete dominance. This is the only kind of trait that Mendel studied althoug ...
Selection - Seattle Central College
Selection - Seattle Central College

... success* – “Bout” of selection: An event that alters allele frequencies ...
Chronic Stable Angina
Chronic Stable Angina

... sublingual nitroglycerin (NTG) use. The patient’s isosorbide mononitrate (ISMN), an alternative agent for symptoms relief that dose not reduce heart rate, is commonly associated with hypotension especially at his higher dosage. According to a statement by AHA selective COX-2 inhibitors such as celec ...
No Slide Title - Computer Science Department, Technion
No Slide Title - Computer Science Department, Technion

... ‫‪ .3‬אללים מרובים )‪,(A,B,O‬‬ ...
pbresource
pbresource

... The Search for Alternative Methods of Parental Selection The approach whereby 'good by good' parental hybridizations are made has shown time and again to have the highest probability of producing superior progenies. Breeders desire to increase the frequencies of parental combinations that produce s ...
Notes
Notes

... - _________________________ variation: differences among individuals in the composition of their genes or other DNA sequences - Some heritable phenotypic differences occur on an ‘either-or’ basis - Typically determined by a __________________ gene locus with different alleles producing distinct phen ...
Antibiotic Residue Avoidance Strategy
Antibiotic Residue Avoidance Strategy

... labeled for IM use only, and that IM injections if required, be limited to not more than 10 cc per injection site. These injection site guidelines have been adopted by all state BQA programs. Almost all of our pharmaceutical and biological product suppliers and government agencies responsible for th ...
Carbamazepine overdose after exposure to simethicone
Carbamazepine overdose after exposure to simethicone

... A 45 year old male patient with a medical history of epilepsy presented to our emergency room with complaints of vertigo, gait disturbance, dizziness, slurred speech, and diplopia. He was using Carbamazepine (Karazepin®) 400 mg three times /day for four years and Keppra® twice daily for one year. No ...
human genotyping- cegen unit
human genotyping- cegen unit

... Ewing sarcoma ( ES ) is relatively uncommon, despite being the second most frequent primary malignant bone tumour in children and adolescents after osteosarcoma. Despite considerable progress made during the past decades, many individuals still relapse or suffer from adverse drug reactions ; this ha ...
Prescribing Information
Prescribing Information

... Following an acute overdosage of butalbital, acetaminophen and caffeine, toxicity may result from the barbiturate or the acetaminophen. Toxicity due to caffeine is less likely, due to the relatively small amounts in this formulation. Signs and Symptoms Toxicity from barbiturate poisoning include dro ...
Adverse drug reactions: definitions, diagnosis, and management
Adverse drug reactions: definitions, diagnosis, and management

... medicines, or of chemically related or pharmacologically related compounds. Some patterns are pathognomonic or nearly so; for example, in a patient taking digoxin, a combination of heart block and an ectopic arrhythmia will almost certainly be due to the drug. However, this information should not be ...
Prescribing Information - Recordati Rare Diseases
Prescribing Information - Recordati Rare Diseases

... “Aspirated the powder” ...
AE-SAE Reporting Guidelines v2.0
AE-SAE Reporting Guidelines v2.0

... These guidelines apply to the site Principal Investigator (PI) and all site staff who have been delegated the task of recording and reporting AEs/SAEs. Responsibilities of the Clinical Research Support Centre (CRSC) The CRSC acting on behalf of the Sponsors have been delegated responsibility for pha ...
Synthetic Drugs of Abuse
Synthetic Drugs of Abuse

... in Indianola, Iowa smoked a synthetic cannabis product, had no history of depression, complained to a friend that he “Felt like was in Hell”, went home and shot himself in the head with a shotgun. • Recently reported case series of STEMI with elevated troponins, and clean caths were identified in 3 ...
Some aspects of Androgenic alopecia treatment Gladko
Some aspects of Androgenic alopecia treatment Gladko

... causes and mechanisms of androgenic alopecia development in details. In 1988 he introduced a new definition – androgenic alopecia, by that he emphasized the role of genetic predisposition of hair follicle to androgen reaction. The majority of men and woman have this form and its frequency ranges fro ...
The DEA`s War on Doctors - Association of American Physicians and
The DEA`s War on Doctors - Association of American Physicians and

... There is an historical parallel with the DEA’s current prosecution of medical doctors in its war on drugs. Before World War I, narcotics were legal and widely used to relieve pain and treat illness. The public was unaware of the addictive potential of these drugs. For example, morphine was commonly ...
Genetics and genomics
Genetics and genomics

... • People affected produce several symptoms that vary ...
the frequency of the factor v leiden (f5)1691g>a allele among sri
the frequency of the factor v leiden (f5)1691g>a allele among sri

... placental abruption, and intrauterine growth retardation (IUGR) have also been associated with FVL. Previously published data indicate that female heterozygote’s for F5 1691G>A variant are at increased risk for severe pre eclampsia and other adverse pregnancy outcomes as well as DVT (22, 23). But a ...
Pharmacology-Pain Managementt
Pharmacology-Pain Managementt

... tissue to the point that it may cause severe muscle fibrosis. b. Metabolite-Normeperidine has convulsant activity and may cause neurological adverse effects. c. Often combined with Phenergan to increase analgesia but is associated with increased renal effects. d. Meperidine’s use within 14 days of M ...
Predicting new molecular targets for known drugs
Predicting new molecular targets for known drugs

... Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and efficacy. Because many drug–target combinations exist, it would be useful to explore possible interactions computationally. Here we compared 3,665 US Food and Drug Administra ...
Pandura Tablet Insert Size : L 4.25" x H 8.5"
Pandura Tablet Insert Size : L 4.25" x H 8.5"

... into three doses. Dosage may be increased in increments of 0.5 to 1 mg every 3 days until seizures are adequately controlled or until side effects preclude any further increase. Maintenance dosage must be individualized for each patient depending upon response. Maximum recommended daily dose is 20 m ...
- Prescient Therapeutics
- Prescient Therapeutics

... prior treatments of chemotherapy.    ...
What To Disseminate Adopt Implement?
What To Disseminate Adopt Implement?

... managed care plans. Joint Commission on Quality Improvement, 26 (11), 633-643.; Garnick, D.W., Lee, M.T., Chalk, M., Gastfriend, D., Horgan, C.M., McCorry, F., McLellan, A.T., & Merrick, E.L. (2002). Establishing the feasibility of performance measures for alcohol and other drugs. Journal of Substan ...
Gregor Mendel “The Father of Genetics”
Gregor Mendel “The Father of Genetics”

... Genes are inherited in pairs, one allele from each parent Homozygous: identical alleles Heterozygous: different alleles In a hybrid, only the dominant allele (T) will be expressed (or seen). The other allele is recessive (t). Alleles segregate (separate) from each other during gamete formation and r ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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