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factor ix (human) - DavisPlus
factor ix (human) - DavisPlus

... (units) ⫽ body weight (kg) ⫻ 1 unit/kg ⫻ desired factor IX increase (% of normal). Recombinant DNA product— Dose (units) ⫽ body weight (kg) ⫻ 1.2 units/kg ⫻ desired factor IX increase (% of normal). ...
Broad-Sense Heritability Index
Broad-Sense Heritability Index

... If we randomly draw a sperm and an egg from the gene pool, then pair them to make a zygote, the probability that both sperm and egg will carry the A allele = p x p, or p2. ...
GHB or gamma-hydroxybutyrate
GHB or gamma-hydroxybutyrate

... doses, anaesthetic properties (that means it knocks you out). Depressant drugs slow brain and central nervous system activity. GHB has been identified as a 'date-rape drug' because it leaves users with amnesia, impaired movement and speech. It can be easily camouflaged in drinks as it is difficult t ...
My experience with 12-hour dosing of OxyContin” Practical Pain
My experience with 12-hour dosing of OxyContin” Practical Pain

... premise’ that patients receiving OxyContin at intervals more frequent than twice-daily are at increased risk of ‘side effects and serious adverse reactions.’ In doing so, the agency reinforced the twice-daily labeling for OxyContin. The LAT omitted the findings of this report from its story.” ...
About the Creeper Gene
About the Creeper Gene

... There are a number of lethal genes in poultry, however in Japanese bantams, the Creeper (Cp) allele is the offender. This is a skeletal shortening mutation which is also found in other shortlegged breeds such as Scots Dumpies. Before we can understand how the Creeper allele works, we have to have a ...
Summary of topics Timeline of Mendelian genetics
Summary of topics Timeline of Mendelian genetics

... response have over 200 alleles. Organ transplants have a much higher success rate when donor and recipient are matched for their HLA genes, but the high level of variation makes this difficult. polymorphic: a genetic locus is polymorphic if it has 2 or more different allelic forms. ...
Drugs Used to Treat Autism and their Effectiveness
Drugs Used to Treat Autism and their Effectiveness

... • Schedule for activities individual enjoys – computer – reading – Drawing ...
DPICtions Summer 2016 | Cincinnati Drug and Poison Information
DPICtions Summer 2016 | Cincinnati Drug and Poison Information

... easy to give in a once a month injection to curb cravings for drugs. Lt. Isaac discussed the difficulties of getting heroin dealers off the streets. He stated that at a price of $160 for a gram of heroin, the amount of money a dealer can make is lucrative. It is hard for them to see drug exchanges b ...
Challenges Associated with Current and Future TB
Challenges Associated with Current and Future TB

... successfully developed for use in human medicine. Pleuromutilins are metabolized by liver enzymes and eliminated from the body at a very high rate — a major obstacle to developing the class for human oral treatment [32]. GlaxoSmithKline (GSK) has been working to develop an oral pleuromutilin for the ...
FEATURE: A structure, characteristic, or behavior of an organism
FEATURE: A structure, characteristic, or behavior of an organism

... Together they constitute a gene. Summary •  Nuclei contain chromosomes. •  Chromosomes come in almost identical pairs. •  Chromosomes have specific active locations called alleles. •  The two alleles in identical locations on paired chromosomes constitute a gene ...
Plano Police Department Narcotics Unit
Plano Police Department Narcotics Unit

... Has the risk increased? ...
Math 121 – Final Lab
Math 121 – Final Lab

... cancer. Since cancer cells are very similar to your normal body cells, their destruction relies on very toxic drugs. There are some very fine lines in certain cancer treatments between an ineffective dose, one that destroys the cancer, and one that is toxic to all cells in the body. At the base of m ...
Challenges in communicating genetics: A public health
Challenges in communicating genetics: A public health

... reinforcing a view of humans as a product of their genes, to the exclusion of nongenetic factors.lO-l2Early discoveries of severe and often incurable conditions may have raised concerns about genetic determinism (e.g., Tay-Sachs disease, Huntington disease). Indeed, many of these disorders can be tr ...
legal highs - Street Aware
legal highs - Street Aware

... substance is legal it does not mean it is safe. Drugs intended for human consumption must be regulated under the Medicines Act, and therefore undergo rigorous testing to determine how they can be used safely. Most legal highs are illegal to sell, supply or advertise for human consumption because of ...
Translation of Drug Metabolic Enzyme and Transporter (DMET) Genetic Variants into Star Allele Notation using SAS.
Translation of Drug Metabolic Enzyme and Transporter (DMET) Genetic Variants into Star Allele Notation using SAS.

... level variants within the gene that must be present on a chromosome for that chromosome to have the indicated star allele. For example, 517C>T indicates that the major allele, C, is replaced by variant or minor allele, T, at the 517 nucleotide position in the CYP4B1 gene. If this variant occurs on a ...
Urinary Incontinence Drugs
Urinary Incontinence Drugs

6_ARV_Drug_Toxicity
6_ARV_Drug_Toxicity

... • May lead to a reduction in the quality of life. • May be an important cause of non-adherence to therapy. REMEMBER: Overall experience in Botswana has shown that ARV medications are very well tolerated by the vast majority of patients! ...
Drug and Chem-informatics Databases - BIDD
Drug and Chem-informatics Databases - BIDD

... Drug ADME Associated Protein Database (http://bidd.nus.edu.sg/group/admeap/admeap.asp) – A database for facilitating the search for drug Absorption, Distribution, Metabolism, Excretion associated proteins. It contains information about known drug ADME associated proteins, functions, similarities, su ...
Chapter 3 Mendelian Genetics
Chapter 3 Mendelian Genetics

... hybridization was performed with pollen and ovum for all crosses to prove that pollen or ovum didn’t play a role in expression of the trait. ...
Genotype
Genotype

... User bias and premature filtering ...
Biological theories of offending (slides)
Biological theories of offending (slides)

Drugs and the Synapse
Drugs and the Synapse

... • Amphetamines stimulate dopamine synapses by increasing the release of dopamine from the presynaptic terminal. • Cocaine blocks the reuptake of dopamine, norepinephrine, and serotonin. • Methylphenidate (Ritalin) also blocks the reuptake of dopamine but in a more gradual and more controlled rate. – ...
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... 19. What are the AT1 receptor antagnoists? What are the advantages of using AT1R antagonists over ACE inhibitors (2)?  -sartan drugs such as losartan & valsartan  inhibit the renin-angiotensin pathway more fully  avoid the side effects of cough and angiodema since they do not affect bradykinin 20 ...
Tetracycline - Doctors Foster and Smith
Tetracycline - Doctors Foster and Smith

... with other medications, used to treat psittacosis. Dose and Administration Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. Use all of the medication prescribed. If your pet does not receive the entire cours ...
2nd T. 6th L. Updated - Home - KSU Faculty Member websites
2nd T. 6th L. Updated - Home - KSU Faculty Member websites

...  Ketorolac is a heterocyclic acetic acid derivative. It is a potent analgesic but only a moderately effective antiinflammatory drug  It has a rapid onset of action, extensive protein binding, and a short duration of action. Oral bioavailability is about 80%. Urinary excretion accounts for about 90 ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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