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Click here for the PowerPoint presentation
Click here for the PowerPoint presentation

... problems • Avoids duplication of clinical effect ...
Malaria: Natural Selection and New Medicine
Malaria: Natural Selection and New Medicine

... Have students read the synopsis and watch the video. Use the following questions to guide a class discussion. • Why is malaria considered one of the most important infectious diseases in the world? (Answer: There are over 300 million new cases each year and about 1 million annual deaths from the dis ...
PHARMACOLOGY
PHARMACOLOGY

... cells, identification of specific antibody producing hybrid cell lines. Applications of monoclonal antibodies in clinical, treatment, and biomedical research. Monoclonal antibodies as therapeutic agents, preventing rejection of transplanted organs, treatment of bacterial blood infections. Chemically ...
Chronobiology: Pulsatile Drug Delivery System
Chronobiology: Pulsatile Drug Delivery System

... delivery system is fulfilling all this requirements. The principal rationale of pulsatile drug delivery system is that it is best suited for those where zero order release is not required. Keywords: Chronobiology, Circadian rhythm,Clock genes, Pulsatile drug delivery system ...
Alcohol & Prescription drugs
Alcohol & Prescription drugs

... Mixing alcohol and medicines can be harmful. Alcohol, like some medicines, can make you sleepy, drowsy, or lightheaded. Drinking alcohol while taking medicines can intensify these effects. You may have trouble concentrating or performing mechanical skills. Small amounts of alcohol can make it danger ...
Pain and Progress Is it possible to make a nonaddictive opioid
Pain and Progress Is it possible to make a nonaddictive opioid

... God to give to man to relieve his sufferings, none is so universal and so efficacious as opium.” Today, physicians write more than 200 million prescriptions for opioid painkillers in the U.S. each year. But it’s well known that opioids have a dark side. As good as the drugs are at stopping pain, the ...
Novel Therapies and New Targets of Treatment for Familial
Novel Therapies and New Targets of Treatment for Familial

... FAHA, FNLA Associate Professor of Medicine Washington University School of Medicine May 16, 2010 ...
GDriftlab
GDriftlab

... trait depends on the size of the population. In large populations, genetic drift tends to be a relatively weak force of evolution: the loss of just a few alleles due to chance will barely change the allele percentages of a very large group. But if/when populations are very small, such as during popu ...
Antibiotics in Endodontics
Antibiotics in Endodontics

... . By stimulating the development of resistant strains of bacteria, these medications permanently alter the microbial environment. Dentist, physicians and patients have a serious responsibility to understand why antibiotics must be administered with caution and to adhere to the principles that govern ...
10158-28698-1
10158-28698-1

... In vitro, the CYP2C9*2 and CYP2C9*3 variants, code for enzymes with approximately 10–40% and 5–15% of the activity of the wild-type CYP2C9*1, respectively [8].The decreased CYP2C9 activity may cause slow metabolism, and thus, a higher plasma concentration of rosuvastatin, which increases the risk of ...
Atomoxetine for ADHD in children and adolescents
Atomoxetine for ADHD in children and adolescents

... other cardiovascular symptoms.  heart rate and blood pressure (plotted on a centile chart).  height and weight (plotted on a growth chart).  family history of cardiac disease and examination of the cardiovascular system  an electrocardiogram (ECG) if there is past medical or family history of se ...
r-allergytoNSAID
r-allergytoNSAID

... with or without nasal polyps, or who exhibit bronchospasm after taking aspirin or other nonsteroidal anti-inflammatory drugs. Fatal reactions have been reported in such patients. It is not true, however, that an individual allergic to one NSAID is allergic to all NSAIDs. Some individuals, who are al ...
Pain Management
Pain Management

... Cytochrome P450 2D6 [Cytochrome P450 3A4] ...
Standard of Practice: Safe Handling of Hazardous Drugs (HDs)
Standard of Practice: Safe Handling of Hazardous Drugs (HDs)

... c. Unless contraindicated by FDA approved product labeling or protocol specifications, cover the area where an HD has been applied with gauze or coverlet dressing to prevent contamination of surfaces. d. HDs should be wiped off or removed as best as possible prior to entering a shower or hydrotherap ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)

... also because malignancy patients are already compromised as discussed previously. In this study we observed there was markedly decreased bleeding and better operative conditions thus increasing surgeon satisfaction in group D as compared to group S .Our findings are in accordance with the studies by ...
Integrating Gene Expression Analysis into Genome-Wide
Integrating Gene Expression Analysis into Genome-Wide

... Schadt EE, Monks SA, Friend SH (2003) A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets. ...
Diversity Analysis - ACS Division of Chemical Information
Diversity Analysis - ACS Division of Chemical Information

... One needs to distinguish “leadlike” leads from other sources of lead structures, e.g., natural products that are high-affinity compounds (NPY or taxol are leads!) or from “druglike” leads that are marketed ...
Precision Medicine: Using Patient`s Race as a Pragmatic Indicator of
Precision Medicine: Using Patient`s Race as a Pragmatic Indicator of

... Personalized medicine “refers to the tailoring of medical treatment to the individual characteristics of each patient. It does not literally mean the creation of drugs or medical devices that are unique to a patient, but rather the ability to classify individuals into subpopulations that differ in ...
One-Way Independent Samples ANOVA with SAS
One-Way Independent Samples ANOVA with SAS

... At the bottom of the output is a plot of the means. Take a look at the plot. It appears that the drug is quite effective with 10 and 20 mg doses, but that increasing the dosage beyond that reduces its effectiveness (perhaps by creating problems opposite to those it was intended to alleviate). With d ...
Issues
Issues

... individual indefinitely or at the very least, slowing it down significantly. What are the ethical ramifications of such an act? What are the practical ramifications? Question 3: Ultrasound is routinely used during pregnancy to monitor the development of the fetus. It is also used to perform amniocen ...
DISSOLUTION ENHANCEMENT OF TELMISARTAN BY LIQUISOLID COMPACTS  , Research Article
DISSOLUTION ENHANCEMENT OF TELMISARTAN BY LIQUISOLID COMPACTS , Research Article

... the prevention and treatment of hypertension [7]. It belongs to class II drugs, these types of drugs according to biopharmaceutical classification system characterize by low aqueous solubility and high permeability [8] and often solubility is the rate-limiting step for absorption [9]. Thus, one of t ...
document - medSask
document - medSask

... Following conversion to clonazepam, some dose titration may be required to achieve the desired therapeutic effect. Clinical judgement is necessary to determine the optimum dose for each patient. Patients should be carefully monitored for changes in seizure frequency, as well as the emergence of any ...
Critical Care Calculations Study Guide
Critical Care Calculations Study Guide

... Ordered amount of drug x pt’s weight x 60 (minutes/hr) Drug concentration Example #3 Lidocaine is ordered a 1 mg/min. Your IV has 2 grams of Lidocaine in 500 mL. What rate will your IV run at? 1. Always begin by determining the amount of medication in each mL. 2 grams = 0.004 gm/mL ; 500 mL 2. Do yo ...
the file - Brighton and Hove CCG
the file - Brighton and Hove CCG

... 1. Link to the relevant SPC website: http://www.medicines.org.uk/emc/ 2. Background to use for the indications, including licence status: Leflunomide tablets are used as an immunosuppressant either alone or in combination with other agents which influence the immune response. It has a marketing auth ...
FILTUS
FILTUS

... identifiers and variant positions are irreversibly masked or changed. However, care has been taken to preserve dependencies between the variants, so that the answers you find are almost identical to the actual analysis of this patient. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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