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Medication Errors
Medication Errors

... • Describe high risk medications and safe medication practices. • Explain the process for reporting an adverse drug event or medication error. • List four practices that can prevent medication errors and adverse events. ...
Diovan (Chronic Heart Failure) - Forecast and Market Analysis to... Brochure
Diovan (Chronic Heart Failure) - Forecast and Market Analysis to... Brochure

... and more branded products are expected to lose market exclusivity during the next few years. GlobalData predicts that the major global barriers that will play a crucial role in narrowing the global growth of the CHF market over the forecast period include the sparsely populated CHF pipeline and an i ...
SBIRT: A Step-By
SBIRT: A Step-By

... and can be completed within a few minutes. These questions are like other tests in medical practice and have been validated as such. They may not work as well if altered. Recommended screening and assesment instruments have high sensitivity and specificity.8, 23, 24, 25, 26,27 All practices should r ...
Bioinformatics
Bioinformatics

...  Should consider more than just base or amino acid differences. Synonymous changes are less significant than non-synonymous and conservative changes less significant than non-conservative.  Does not account for functions of “orthologs”. In many cases, an analysis will be based on the assumption th ...
Just What the Doctor Ordered: Using SAS to Calculate Patient Drug Dose with Electronic Medical Record (EMR) Prescription Data
Just What the Doctor Ordered: Using SAS to Calculate Patient Drug Dose with Electronic Medical Record (EMR) Prescription Data

... Electronic medical records (EMRs) are paperless digital versions of physicians’ paper charts. EMRs can contain a myriad of health care information – including details of physician drug prescriptions – and research efforts with EMR data often include determining patient drug treatment patterns and do ...
Harvard-MIT Division of Health Sciences and Technology
Harvard-MIT Division of Health Sciences and Technology

... Metabolism is primarily hepatic; induces own metabolism, as well as that of other drugs (OCP’s, warfarin, other anticonvulsants particularly problematic). Half-life is 10-20 hours; tid dosing usually satisfactory, although qid sometimes required Several active metabolites, including a 10,11 ep ...
32-05 CASA Investigators Meeting Paris November 2005
32-05 CASA Investigators Meeting Paris November 2005

... Approaches: adjuvant CT Advanced age and endocrine non-responsive breast cancer represent a therapeutic dilemma. The physician may decide not to offer a relatively frail patient any treatment for fear of possible subjective or severe toxic effects of chemotherapy. Patients may be treated in a heter ...
Product Manual
Product Manual

... Increase of dosage and treatment duration promotes dependence. If you need a dose increase, it should be done slowly. Administration of Fenazepam Olainfarm for several weeks at doses higher than 4 mg a day can develop physical and psychic dependence. Patients who have had an addiction to alcohol or ...
Main Title Slide — Always use Title Case on
Main Title Slide — Always use Title Case on

... Source: Schlenk RF, Döhner K. Curr Opin Hematol 2009;16:98-104. ...
TAY-SACHS DISEASE AND OTHER CONDITIONS MORE
TAY-SACHS DISEASE AND OTHER CONDITIONS MORE

... Many of these genes code for enzymes that are important in the functioning of the central nervous system. When there are mutations present in these genes, the corresponding protein is not produced correctly and symptoms of the condition develop. ...
Anticoagulants Drugs
Anticoagulants Drugs

... structurally related to vitamin K. Pharmacokinetics: Route of administration: p.o.; 100% absorbed; 99% ...
32-05 CASA Investigators Meeting Paris November 2005
32-05 CASA Investigators Meeting Paris November 2005

... Approaches: adjuvant CT Advanced age and endocrine non-responsive breast cancer represent a therapeutic dilemma. The physician may decide not to offer a relatively frail patient any treatment for fear of possible subjective or severe toxic effects of chemotherapy. Patients may be treated in a heter ...
Drug Discovery-New Drug Development Process
Drug Discovery-New Drug Development Process

... natural product without a prescription. ...
Genomic Measures of Relationship and Inbreeding
Genomic Measures of Relationship and Inbreeding

... alleles of quantitative trait loci (QTL) that two individuals share only for loci that affect a specific trait. The term QTL often refers to loci with the largest effects but includes all loci that affect the trait in this paper. Matrix T requires both phenotypic and genotypic data to estimate QTL l ...
Post- Modern Synthesis: Genomic Conflict as a Driving Force in
Post- Modern Synthesis: Genomic Conflict as a Driving Force in

... Evolution in Mendelian Populations • Evolution can be defined as a change in gene frequency through time. Population genetics tracks the fate, across generations, of Mendelian genes in populations. Population genetics is concerned with whether a particular allele or genotype will become more or less ...
Gastro-intestinal System - Eastbourne, Hailsham and Seaford CCG
Gastro-intestinal System - Eastbourne, Hailsham and Seaford CCG

... 2. Offer empirical full-dose PPI therapy for 4 weeks to people with dyspepsia. 3. If there is an inadequate response to a PPI, offer H2 receptor antagonist (H2RA) therapy instead. C. Interventions for gastro-oesophageal reflux disease (GORD) 1. Offer patients who have GORD a full dose PPI for 4-8 we ...
Hepatitis C Therapy Prior Authorization
Hepatitis C Therapy Prior Authorization

... Harvoni ®: --Take __________ tablet(s) once daily for __________weeks Sovaldi ® (sofosbuvir) 400mg: – Take once daily for __________ weeks Viekira Pak ™: -Take as directed for __________ weeks Olysio ® (simeprevir) 150mg: – Take once daily for __________weeks Ribavirin__________ mg – Take __________ ...
Albinism Powerpoint
Albinism Powerpoint

...  OCA-1, OCA-2, and OCA-3 • OCA-1: occurs on chromosome 11 •OCA-2: occurs on chromosome 15 ...
Working title: Target Repurposing for Neglected Diseases
Working title: Target Repurposing for Neglected Diseases

... prediction and confirmation of parasite protein sequences, and prioritization of putative targets ...
   Genetic influence on enantiomeric   drug disposition:  Focus on venlafaxine and citalopram 
   Genetic influence on enantiomeric   drug disposition:  Focus on venlafaxine and citalopram 

... inherited  differences  in  the  nucleotide  sequences  in  the  DNA,  defined  as  genetic  polymorphism  (Ingelman‐Sundberg,  2004).  Genetic  polymorphism  can  be  seen  in  both drug metabolising  enzymes, drug  transporters and  receptors.  Consequently,  it  can  affect  drug  metabolism,  ab ...
GeneticVariation03
GeneticVariation03

... The evolution of diverse species within and among the vertebrate classes is due, originally, to genetic variation. What are the sources of genetic variation? I. Mutation in DNA. II. Sexual reproduction (meiosis and recombination of alleles as shown on Punnett squares). III. Unique inheritance patter ...
Ch 14 Review Questions
Ch 14 Review Questions

... separate (segregate) during gamete formation and end up in different gametes. Thus, an egg or a sperm gets only one of the two alleles that are present in the somatic cells of the organism. In terms of chromosomes, this segregation corresponds to the distribution of homologous chromosomes to differe ...
DEPRESSION: MASTER
DEPRESSION: MASTER

...  Benefits from medication appear slowly.  Continue antidepressants even after you feel better.  Mild side effects are common, and usually improve with time.  If you’re thinking about stopping the medication, call me first.  The goal of treatment is complete remission; sometimes it takes a few t ...
DRUG RECOGNITION AND TRENDS
DRUG RECOGNITION AND TRENDS

... • Sometimes referred to as narcotics • Are prescribed because of their effective analgesic or pain relieving properties. • Opioids act by attaching to opioid receptors found in the brain, spinal cord and gastrointestinal tract. • Opioid drugs can also affect regions of the brain that mediate what we ...
Novel Compound Heterozygous DYSF Mutations Lead
Novel Compound Heterozygous DYSF Mutations Lead

... staining shows misaligned intermyofibrillar networks and lobulated muscle fibers (B). Succinate dehydrogenase (SDH) staining shows muscle fiber with mitochondrial proliferation (C). Modified Gomori’s trichrome (MGT) staining shows ‘ragged red fiber’ (D). Monoclonal anti-dysferlin antibody NCL-Hamlet ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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