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Full Prescribing Information for TOPAMAX® (topiramate)
Full Prescribing Information for TOPAMAX® (topiramate)

... concomitant valproic acid use: Patients with inborn errors of metabolism or reduced mitochondrial activity may have an increased risk of hyperammonemia. Measure ammonia if encephalopathic symptoms occur (5.10)  Kidney stones: Use with other carbonic anhydrase inhibitors, other drugs causing metabol ...
Studies - The British Journal of Psychiatry
Studies - The British Journal of Psychiatry

... The total numbers of deaths, prescriptions and episodes of selfpoisoning are given in Table 1 (see online Table DS1 for data stratified by gender). The antidepressants most frequently involved in suicide deaths were (in order) dosulepin, amitriptyline, venlafaxine and citalopram. For non-fatal poiso ...
Neural mechanisms underlying morphine withdrawal in addicted
Neural mechanisms underlying morphine withdrawal in addicted

... withdrawal period. As well as to muscle spasms, severe pain in the bones and muscles of the back and extremities will be appeared. A suitable narcoticmay be administered to reverse the withdrawal symptoms at any points over this process. Major withdrawal symptoms peak 48 to 96 hours subsequent to th ...
Statin-‐Induced Myotoxicity: Is Vitamin D Deficiency the Cause for
Statin-‐Induced Myotoxicity: Is Vitamin D Deficiency the Cause for

... A. Prior  to  re-­‐trial  of  statin  therapy,  a  “drug  free  holiday”  is  recommended  which  is  typically  defined  in   clinical  practice  as  a  six  week  period  free  of  statin  therapy  13   B. Statin  re-­‐trial  with  al ...
The Glycine Transporter-1 Inhibitor SSR103800 Displays a
The Glycine Transporter-1 Inhibitor SSR103800 Displays a

... (Giros et al, 1996). In DAT/ mice, DA levels in the synapse are dramatically elevated and these animals are hyperactive and agitated in behavioral tests. Moreover, DAT/ mice show a deficit in pre-pulse inhibition (PPI) of the startle response (Ralph et al, 2001; Powell et al, 2008), a behavioral ...
8 Ultra-low-dose opioid antagonists enhance opioid analgesia while
8 Ultra-low-dose opioid antagonists enhance opioid analgesia while

... vomiting, pruritus, insomnia, constipation, sedation and impaired physical function (Ballantyne and Mao, 2003). In many cases, patients taking opioids are balancing side effects with analgesia, often choosing to tolerate a certain amount of pain so as to avoid side effects. The more severe side effe ...
Medication Administration in the School Setting: Guidelines  Colorado Department of Education
Medication Administration in the School Setting: Guidelines Colorado Department of Education

... should read their district policies carefully, especially with regard to medications on field trips. The preparation of individual doses of medications for field trips is not ...
Management of obesity: improvement of health-care training
Management of obesity: improvement of health-care training

... of adult obesity. In adults, both BMI and waist circumference are used to assess the risks of cardiovascular disease, including hypertension, stroke, dyslipidaemia, non-alcoholic fatty liver disease, and type 2 diabetes. The Edmonton obesity staging system (EOSS) has been used to provide additional ...
xanax xanax ts
xanax xanax ts

... withdrawal symptoms may occur with benzodiazepine discontinuation and can be severe (eg, seizures) if benzodiazepines are suddenly discontinued or upon rapid dose decrease (see DOSAGE AND ADMINISTRATION, Recommended Dose and Dosage Adjustment Discontinuation). Even after relatively short-term use (e ...
attenuation of hemodynamic response to extubation with injection
attenuation of hemodynamic response to extubation with injection

... pulmonary oedema if lung volumes are less than vital capacity. They also cause ...
Naturally Occurring and Related Synthetic Cannabinoids and their
Naturally Occurring and Related Synthetic Cannabinoids and their

... In vivo Testing of endocannabinoids produce behavioral and pharmacological actions associated with other cannabimimetic ligands. Anandamide (5a) produces antinociception, hypothermia, hypomobility, and catalepsy in the mouse tetrad model, with rapid onset of effects, but with a short duration of act ...
B2 agonist review Manuscript - Revised3
B2 agonist review Manuscript - Revised3

... attack, it is difficult to imagine how β2-agonist induced tachyphylaxis could be occurring. Therefore we need to look into greater detail at what is actually occurring in the lungs. Airway Physiology, mucous and virus-induced lung attacks. The lungs are composed of a series of branching airways that ...
PIRACETAM ñ AN OLD DRUG WITH NOVEL PROPERTIES?
PIRACETAM ñ AN OLD DRUG WITH NOVEL PROPERTIES?

... improvement of sensorimotor deficits is unchallenged, the efficacy of speech therapy is still questionable/unclear. Whether the rehabilitation can be enhanced by adjuvant pharmacotherapy in patients with cerebral disorders is also a matter of speculation (20ñ22). First trials were started in the 194 ...
Seroquel - PI
Seroquel - PI

... WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIARELATED PSYCHOSIS; and SUICIDAL THOUGHTS AND BEHAVIORS Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of d ...
The Acceleration of Articular Cartilage Degeneration in
The Acceleration of Articular Cartilage Degeneration in

... Ross A. Hauser, MD ...
Clindamycin in 0.9% Sodium Chloride Injection
Clindamycin in 0.9% Sodium Chloride Injection

... with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate [see Indications and Usage (1)]. It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections. C. difficil ...
How Well Does Methadone Maintenance
How Well Does Methadone Maintenance

... methadone a day. They found that higher doses of methadone are associated with significantly higher treatment retention (in this case a doubling between those who take 40 mgs and day and those who take 75mgs a day). ...
The Serotonin Syndrome - Department of Psychiatry
The Serotonin Syndrome - Department of Psychiatry

... agent or the addition of a drug with proserotonergic effects may provoke a dramatic clinical deterioration. The incidence of the serotonin syndrome is thought to mirror the increasing number of proserotonergic agents being used in clinical practice.7 In 2002, the Toxic Exposure Surveillance System, ...
morphine
morphine

... high affinity but low intrinsic activity. • It dissociates slowly from the receptor making it an alternative to methadone for treatment of opioid withdrawal. • It functions as an antagonist at δ and κ receptors.  mixed agonist-antagonist. ...
2 Arterial Hypertension
2 Arterial Hypertension

... Elevated BP demonstrates a consistent, strong, and graded relationship with multiple CV events including CV death, myocardial infarction, stroke, heart failure, and renal dysfunction. The risk of CV mortality has been observed to double with each 20/10 mmHg increase in BP from 115/75 mmHg in adults ...
PrVIBRAMYCIN* CAPSULES
PrVIBRAMYCIN* CAPSULES

... stable calcium complex in any bone-forming tissue, though in vitro it binds calcium less strongly than other tetracyclines. It should be anticipated that the use of VIBRAMYCIN/VIBRA-TABS during tooth development (last trimester of pregnancy, during lactation, neonatal period and early childhood to t ...
Xtram
Xtram

... "nausea/urge to vomit/vomiting" can be increased with rapid intravenous administration and also tends to be dose dependent. No tests of significance have been performed. Drug abuse and dependence Although Tramadol can produce drug dependence of the µ-opioid type (like codeine or dextropropoxyphene) ...
Opioid Antagonists, Partial Agonists, and Agonists
Opioid Antagonists, Partial Agonists, and Agonists

... Background: The opioid receptor antagonists naloxone and naltrexone are competitive antagonists at the mu, kappa, and sigma receptors with a higher affinity for the mu receptor and lacking any mu receptor efficacy. Buprenorphine is classified as a partial agonist. It has a high affinity, but low eff ...
Non-steroidal anti-inflammatory drugs (NSAIDs)
Non-steroidal anti-inflammatory drugs (NSAIDs)

... question indicates the need for more education for physiotherapists on the current legislative position regarding NSAIDs. As with knowledge of side effects and appropriate use of NSAIDs, any inaccuracies in the knowledge physiotherapists have about legislation could have potentially serious conseque ...
LMX4 SmPC SOP FPL21 Appendix version-3
LMX4 SmPC SOP FPL21 Appendix version-3

... venous cannulation or venipuncture will occur. No more than 1g of cream should be applied to infants below the age of 1 year. 1g of cream equates to approximately 5cm of cream squeezed from the 5g tube or 3.5cm from the 30g tube. The cream should remain undisturbed and the area can be covered with a ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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