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Delineation of a Scab Resistance Gene Cluster on Linkage Group 2
Delineation of a Scab Resistance Gene Cluster on Linkage Group 2

... are merely linked. In any case, the fact that resistance genes are linked, has consequences for the breeding strategy when pyramiding these genes. In a typical modified backcross situation, where the resistant parent is crossed with a susceptible parent with high fruit quality, genes linked in the c ...
Hardy Weinberg Equiibrium with more than 2 alleles
Hardy Weinberg Equiibrium with more than 2 alleles

... Alpine skypilots and bumble bees  Next, she estimated strength of selection by bumblebees by allowing bumblebees to pollinate a caged population of plants, collected seeds and grew plants from seed.  Correlated number of surviving young with flower size of parent. Estimated the selection differen ...
REMERON®
REMERON®

... engaging in hazardous activities until they are reasonably certain that REMERON® therapy does not adversely affect their ability to engage in such activities. Completing Course of Therapy While patients may notice improvement with REMERON ® therapy in 1–4 weeks, they should be advised to continue th ...
How to Use Fentanyl Transdermal Patches for Analgesia in
How to Use Fentanyl Transdermal Patches for Analgesia in

... tients with both visceral and somatic pain, usually those with laminitis secondary to other problems, we noted obvious improvement in the visceral pain, but inconclusive, or only slight improvement in the laminitic pain. This finding is disappointing, because fentanyl seemed a likely addition to the ...
Chapter 12 Patterns of Inheritance
Chapter 12 Patterns of Inheritance

... Remember: An individual will have only a maximum of two unique alleles for a gene(diploid) ...
Melanie_Sunderland_Jan_23,_2014
Melanie_Sunderland_Jan_23,_2014

... Paranoia ...
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co- formulation
Anticancer efficacy and toxicokinetics of a novel paclitaxel-clofazimine nanoparticulate co- formulation

... acclimatized to the laboratory conditions of Charles River Laboratories (Ann Arbor, Michigan, USA). The mice were fed standard irradiated rodent food and water ad libitum. The mice were housed in static cages with sterile bedding inside clean rooms that provide HEPA filtered air into the barrier env ...
Modern Methods in Drug Discovery
Modern Methods in Drug Discovery

... the remaining k-1 subsets as training set respectively. This gives you an average error from the k QSAR equations. In practice k = 10 has shown to be reasonable (= 10-fold cross validation) 6th lecture ...
Facilitating adverse drug event detection in pharmacovigilance
Facilitating adverse drug event detection in pharmacovigilance

... adverse event reporting system (AERS)1 is currently used in the USA as the main source for drug safety surveillance. The FDA receives reports of suspected adverse drug events (ADE),2 which are then entered into the AERS database and used to discover new ADE. Despite its relative success, AERS has so ...
Test Review Genetics08-09
Test Review Genetics08-09

... 41. ______:The alleles for A and B blood types are codominant, and both are expressed in the phenotype 42. ______:A single gene may affect phenotype in many ways. Example: the allele for sickle-cell disease 43. ______:Trait that is controlled by 2 or more genes. This situation creates a continuum of ...
Lecture 9 PP
Lecture 9 PP

... Y (Sex linkage); Some adults have more than two sets of genes (polyploidy); Some "adults" are halpoid (haploidy - e.g. yeast); Some organisms are both (Alternation of generations - e.g. moss) ...
FORMULATION AND EVALUATION OF ATENOLOL ORODISPERSIBLE TABLETS BY PHASE TRANSITION TECHNOLOGY
FORMULATION AND EVALUATION OF ATENOLOL ORODISPERSIBLE TABLETS BY PHASE TRANSITION TECHNOLOGY

... Oral delivery is currently the gold standard in the pharmaceutical industry. Orodispersible tablets a new form of NDDS is “a solid dosage form containing medicinal substance or active ingredient which disintegrate rapidly usually within a matter of seconds when placed upon the tongue”.The aim of thi ...
Farydak - Novartis Pharmaceuticals Corporation
Farydak - Novartis Pharmaceuticals Corporation

... Electrocardiographic abnormalities such as ST-segment depression and T-wave abnormalities also occurred more frequently in patients receiving FARYDAK compared to the control arm: 22% versus 4% and 40% versus 18%, respectively. FARYDAK may prolong cardiac ventricular repolarization (QT interval). Do ...
Report of the Second International Symposium on Molecular
Report of the Second International Symposium on Molecular

... control development tissue growth and differentiation can promote transformation making these cells particularly prone to carcinogenesis. These pathways were elegantly discussed by Rogier Versteeg (Academic Medical Center-TheNetherlands) specifically in neuroblastoma. Embryonal tumours have clinical ...
Ch14_Genetics
Ch14_Genetics

... In humans, being a tongue roller is dominant over nonroller. A man who is a non-roller marries a woman who is homozygous for tongue rolling. (Show the key, Punnett square, and phenotypes / genotypes) ...
Clarifying Adverse Drug Events
Clarifying Adverse Drug Events

... between an adverse drug reaction and an adverse drug event. An adverse drug reaction occurs at usual doses and is caused by the action of the drug, such as renal failure due to ibuprofen. Because the hematoma from tirofiban was the result of an abnormally high dose, it does not qualify as an adverse ...
TYLENOL® with Codeine
TYLENOL® with Codeine

Dose translation from animal to human studies revisited
Dose translation from animal to human studies revisited

... to exist regarding the appropriate method for allometric dose translations, especially when starting new animal or clinical studies. The need for education regarding appropriate translation is evident from the media response regarding some recent studies where authors have shown that resveratrol, a ...
Laws of Inheritance EnBio
Laws of Inheritance EnBio

... Out of these crosses, all of the F1 ospring had the phenotype of one parent, and the F2 ospring had a 3:1 phenotypic ratio. On the basis of these results, Mendel postulated that each parent in the monohybrid cross contributed one of two paired unit factors to each ospring, and every possible comb ...
Document
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... fetus by active placental transport; toxic levels may cause intellectual disability. However, when ingestion is within the usual range, fetal phenylalanine levels are far below toxic levels. Thus, moderate ingestion of aspartame (e.g. no more than 1 liter of diet soda per day) during pregnancy appea ...
Pediatric Grand Rounds: Pain Management in the Pediatric
Pediatric Grand Rounds: Pain Management in the Pediatric

... Synergistic when used in combination with NSAIDs and opioids for moderate to severe pain ...
Chromatin Remodeling - Molecular Pharmacology
Chromatin Remodeling - Molecular Pharmacology

... fluoxetine and cocaine on chromatin remodeling as there are clearly functional differences between the selective 5-HT selective reuptake inhibitors which represent the drug class that is most widely used for the treatment of depression, and psychostimulants such as cocaine that have strong abuse pot ...
Gastrointestinal Drugs
Gastrointestinal Drugs

... What are the assessments and interventions the nurse would do for a client taking an ...
Lipid-based systems as a promising approach for enhancing the
Lipid-based systems as a promising approach for enhancing the

... Most of the newly developed drugs are hydrophobic and therefore poorly water-soluble, which causes difficulties in selecting the proper delivery system to achieve sufficient bioavailability of such drugs. Poor water solubility and dissolution rate are restrictive factors with respect to their absorp ...
anti malaria
anti malaria

... ↑ concentration of quinine Mefloquine Quinine can raise plasma levels of warfarin and digoxin. ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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