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GMVEMSC PREHOSPITAL EMT TRAINING MANUAL VERSION January 1, 2014
GMVEMSC PREHOSPITAL EMT TRAINING MANUAL VERSION January 1, 2014

...  Infrequently, stepwise adherence to specific protocols may not be in the patient’s best interest. No protocol can substitute for the EMS professional’s judgment. However, at no time should treatment options exceed those authorized without direct consultation with Medical Control. In all such cases ...
Thyroid hormones and antithyroid drugs
Thyroid hormones and antithyroid drugs

... – Can dose just prior to meals with better post-prandial control – Fewer overnight lows – Ability to skip the dose if skip the meal. • Efficacy for repaglinide appears to be similar to SU’s ...
A comparison of the tolerability of the direct renin inhibitor
A comparison of the tolerability of the direct renin inhibitor

... 90 mm Hg. Due to the large BP reductions required for patients with severe hypertension to reach their treatment goals, combination therapy is almost invariably required. Existing antihypertensive therapies are associated with high rates of discontinuation, despite the proven clinical benefit of red ...
Tasigna - Novartis Pharmaceuticals Corporation
Tasigna - Novartis Pharmaceuticals Corporation

... dose reduction should be considered and the QT interval should be monitored closely. (5.8)  Total gastrectomy: More frequent follow-up of these patients should be considered. If necessary, dose increase may be considered. (5.13)  Embryo-fetal toxicity: Fetal harm can occur when administered to a p ...
Anticholinergics for Overactive Bladder Therapy: Central Nervous
Anticholinergics for Overactive Bladder Therapy: Central Nervous

... of the tertiary amines [16,17,19–21,25]. Furthermore, oxidative metabolism via the CYP450 system declines with increasing age [41], which may contribute to the observed higher serum levels and/or prolonged elimination half-life of some of these drugs in the elderly [16,17,19,20,25]. Nevertheless, al ...
The Effect of an Individual`s Cytochrome CYP3A4 Activity on
The Effect of an Individual`s Cytochrome CYP3A4 Activity on

... and weekly hematological counts were checked. Granulocytecolony stimulating factor was not given during this first cycle. Subsequent cycles of chemotherapy were given every 3 weeks if the patient was judged by us to be deriving clinical benefit. The pharmacokinetic data were obtained only during the ...
Autacoids
Autacoids

... Androgenic effects (with  doses of cimetidine): e.g. impotence & gynecomastia in men & galactorrhea in women. ...
pain management for the surgical resident
pain management for the surgical resident

... • Moderate to severe pain: increase by 50% 100% • Mild to moderate pain: increase by 25% 50%, irrespective of starting dose • When dose-escalating long-acting opioids or opioid infusions, do not increase the long-acting drug or infusion basal rate more than 100% at any one time, irrespective of how ...
Opioid Analgesics in the Treatment of Chronic Pain, in the Office
Opioid Analgesics in the Treatment of Chronic Pain, in the Office

... without disabling adverse effects. Additionally, treatment options may be limited based on availability and/or health plan policies on covered benefits or drug formularies. Patients share with physicians a responsibility for appropriate use of opioid analgesics [21-22]. This responsibility encompass ...
RNAi and RNAa - The Yin and Yang of RNAome
RNAi and RNAa - The Yin and Yang of RNAome

... Figure 1: RNAa/RNAi constitutes the Yin and Yang of the RNAome. The dual concepts of yin and yang which describe two primal opposing but complementary principles or cosmic forces said to be found in all non-static objects and processes in the universe. This paradoxical concept can potentially be app ...
Detailed Advice  - Scottish Medicines Consortium
Detailed Advice - Scottish Medicines Consortium

... Sorafenib has been considered by SMC using its decision-making framework for the assessment of ultra-orphan medicines. Relevant factors under each of the criteria are summarised below. Nature of the condition Thyroid cancer is usually asymptomatic in the early stages of disease but, as the disease p ...
PDF - The Dermatologist
PDF - The Dermatologist

... 243 individuals in a multi-center setting.2 It also utilized individualized AK treatment and drug incubation of 14 to 18 hours and a blue light source. The study showed >70% of the AKs were cleared with one treatment at 12 weeks and 88% after two treatments. This was statistically superior to a plac ...
Methylergonovine Maleate Injection, USP (0.2 mg/ml)
Methylergonovine Maleate Injection, USP (0.2 mg/ml)

... maleate is administered to a nursing woman. ...
Lorema Reyeg Arianne Nagrampa Simon Evangelio
Lorema Reyeg Arianne Nagrampa Simon Evangelio

... Recently, there have been improvements in the area of stimulant pharmacology, producing a class of chemicals known as ampakines, or eugeroics, (good arousal). These stimulants tend to increase alertness without the peripheral (body) effects or addiction/tolerance/abuse potential of the traditional s ...
Drug Abuse Education Course
Drug Abuse Education Course

... smoking, peak within 20 minutes, and last for two or three hours. • THC is stored in fatty tissue like the brain, liver and reproductive organs. • 2-3 days after use, 50% of the original dose is still present in those tissues. ...
youngs 3-25 - Iowa State University
youngs 3-25 - Iowa State University

... 3) DVM is readily available for followup and is personally acquainted with the keeping and care of the animal by virtue of: – examination of the animal – medically appropriate and timely visit to the premises where the animal is kept ...
Palliative Care And Symptom Management PDF
Palliative Care And Symptom Management PDF

... look at the forest through the trees. It is taking the time with the patient to put the puzzle together so that the patient can understand not only the specifics of his/her disease(s), but the complex inter-relationships of their diagnosis with respect to their values and goals. If someone has not b ...
detection and pathogenetic role of mmr missense mutations
detection and pathogenetic role of mmr missense mutations

... is an autosomal dominant hereditary cancer syndrome, which accounts for 5% of all colorectal cancers. HNPCC is associated with an increased (90% for men, 70% for women) lifetime risk of endometrial, ovarian and other extra colonic cancers. HNPCC syndrome is defined in clinical terms by the revised B ...
Introduction
Introduction

... COPD.11,20 Although it is a long-acting drug, systemic effects with formoterol are as short as salbutamol.10 Relatively, hydrophilic drugs such as salbutamol have rapid onset of action due to their ability to reach the β2 receptor from the aqueous phase.21 Formoterol is a moderately lipophilic drug ...
Gregor Mendel - HCC Learning Web
Gregor Mendel - HCC Learning Web

... A homozygous factor (gene) is one where both alleles are the same (either dominant or recessive) A heterozygous factor (gene) is one where the alleles from each parent are different. ...
Clinical Pharmacokinetics 2012 - Accueil
Clinical Pharmacokinetics 2012 - Accueil

... dosage include age, body weight, smoking status, prior venous thromboembolism, race and certain medications such as amiodarone and antibacterials.[19] Several dosing algorithms that combine clinical and genetic parameters to predict therapeutic warfarin dosage have also been developed; by including ...
Oral Disease-Modifying Therapies for Multiple Sclerosis
Oral Disease-Modifying Therapies for Multiple Sclerosis

... Classical MS treatments using first-line injectable drugs, although widely applied, remain of major concern in terms of therapeutic adherence and efficacy. The IFNs, the first and (still) most commonly used drugs for MS, have been associated with injection-site reactions, flu-like symptoms, and live ...
Roach: Introductory Clinical Pharmacology
Roach: Introductory Clinical Pharmacology

... – Optimal response to drug therapy – Management of patient needs related to adverse drug reactions – Correction of a fluid volume deficit – Absence of injury – Understanding of and compliance with the postdischarge drug regimen Copyright © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins ...
Who Uses Illicit Drugs?
Who Uses Illicit Drugs?

... • Variety of adverse effects: mood swings, acne, liver tumors, elevated cholesterol levels, hypertension, kidney disease • Anabolic Steroids Control Act of 1990 – Schedule III drug Copyright © 2006 Pearson Education, Inc., publishing as Benjamin Cummings ...
lung transplant manual - UCSF | Department of Medicine
lung transplant manual - UCSF | Department of Medicine

... complete presentation is made and opinions welcomed from all participants in the program. Decisions about selection are made by consensus. Evaluation goals The comprehensive transplant evaluation seeks to determine the ability of the patient to benefit from transplantation and to enjoy a successful ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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