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FORMULATION AND EVALUATION OF GUM OLIBANUM­BASED SUSTAINED RELEASE MATRIX  TABLETS OF AMBROXOL HYDROCHLORIDE
FORMULATION AND EVALUATION OF GUM OLIBANUM­BASED SUSTAINED RELEASE MATRIX  TABLETS OF AMBROXOL HYDROCHLORIDE

... In vitro drug release studies14  The  in  vitro  dissolution  studies  for  the  formulated  matrix  tablets  were conducted for a period using USP apparatus type II (paddle) at  100  rpm.  The  dissolution  medium  (900  ml)  consisted  of  0.1N  hydrochloric acid for the first 2 hours and the phos ...
TRIPLEFLEX RAPID RELIEF
TRIPLEFLEX RAPID RELIEF

... White Willow Bark: Four clinical trials on white willow bark with a standardized 15% salicin content found both 240 and 120 mg doses salicin/day effective for joint discomfort relief.10-13 ...
Cytogenetic Study of 48 Patients with Multiple Myeloma and Related
Cytogenetic Study of 48 Patients with Multiple Myeloma and Related

... stage III were +5, +10, −13, −21 and −Y. Loss of chromosome 13 was found in untreated patients and κtype. Their survival times were 3. 5, 4, 10 and 7 months, respectively and the patients associated with −13 were resistant to chemotherapy. The Y chromosome was lost in patients at 38, 45, and 47 year ...
PRODUCT MONOGRAPH INHIBACE PLUS cilazapril and
PRODUCT MONOGRAPH INHIBACE PLUS cilazapril and

...  Are allergic to any sulfonamide-derived drugs (sulfa drugs); most of them have a medicinal ingredient that ends in “-MIDE”.  Have experienced an allergic reaction (angioedema) with swelling of the hands, feet, or ankles, face, lips, tongue, throat, or sudden difficulty breathing or swallowing, to ...
bioavailability enhancdement of poorly soluble drugs by smedds
bioavailability enhancdement of poorly soluble drugs by smedds

... Selfmicroemulsifying drug delivery system(SMEDDS) are defined as isotropic mixtures of natural or synthetic oils, solid or liquid surfactants, or alternatively, one or more hydrophilic solvents and co-solvents/surfactants that have a unique ability of forming fine oil-in-water (o/w) micro emulsions ...
Trait dominant recessive
Trait dominant recessive

... Task 2: Determine, as close as possible, your genotype. To determine your genotype you should collect as much phenotype information about your parents and siblings as available and use that information to determine your genotype. Use the coding (letter) given for each trait, indicate dominant or rec ...
HIV-1 Antiretroviral Drug Resistance and Resistance Testing
HIV-1 Antiretroviral Drug Resistance and Resistance Testing

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One of These Things Is Not Quite the Same: A Comparison of the
One of These Things Is Not Quite the Same: A Comparison of the

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Quantitative Genetics
Quantitative Genetics

... When h2 but H2 high: Little environmental variance! More dominance variance than additive variance. Make use of nonadditive variance. Hybrid-inbred method. ...
Fibrodysplasia Ossificans Progressiva
Fibrodysplasia Ossificans Progressiva

... evidence of non-penetrance in FOP, a case has shown that it is possible that individuals can be silent carriers of the mutated gene (4). Furthermore, a case has suggested gonadal mosaicism, which is a proven cause of recurrence in siblings of other autosomal-dominant disorders or nonpenetrance of th ...
JCleary revised CND-INCB-WHO
JCleary revised CND-INCB-WHO

... controlled substances may raise the risk of diversion and abuse of those substances and that in its annual reports for 2008 and 2009, the International Narcotics Control Board encouraged Governments to increase their vigilance regarding trafficking in and abuse of prescription drugs containing inter ...
Introduction to Pharmacology Chapter 1
Introduction to Pharmacology Chapter 1

... death of patients using this prescription painkiller. OxyContin, approved by the FDA in 1995, is a time-released form of oxycodone, an opium derivative, which is the same active ingredient in Percodan and Percocet. OxyContin is intended for use by terminal cancer patients and chronic pain sufferers. ...
Biology 3A Laboratory Mendelian, Human and Population Genetics
Biology 3A Laboratory Mendelian, Human and Population Genetics

... Note: The chi-square test is more commonly used in a very different situation -- to analyze a contingency table. This is appropriate when you wish to compare two or more groups, and the outcome variable is categorical. For example, compare the number of animals with white fur in two different habit ...
Amish, Mennonite and Hutterite Genetic Disorder Database
Amish, Mennonite and Hutterite Genetic Disorder Database

... UWOMJ, Vol 78, Issue 3  ...
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Read the full press release and study abstracts

... overdose. Tetrahydrocannabinol (THC), the main psychoactive ingredient in marijuana, and endocannabinoids, natural compounds released by the brain, alleviate pain by binding to the CB1 cannabinoid receptor, suggesting a potential therapeutic strategy. However, THC produces the “marijuana high” and c ...
Genetics and Heredity
Genetics and Heredity

... from parent to offspring for each trait.  F1 plants must be heterozygous because the P generation only passed on one tall allele and one short allele.  The F1 plant will then pass on to its offspring either a tall or a short allele, never both. ...
Enteropeptidase: A Gene Associated with a Starvation
Enteropeptidase: A Gene Associated with a Starvation

... proteins and fatty acids. This is in concordance with the phenotype of the enteropeptidase gene as described [8]. The daily requirement of protein is estimated to be between 40–70 grams per day depending on gender, age and activity. However, most experts agree that most people consume twice as much ...
For more information on accessing electronic
For more information on accessing electronic

... Author(s): Subash C. Gupta , Bokyung Sung , Sahdeo Prasad , Lauren J. Webb , Bharat B. Aggarwal Progressively increasing failure rates, high cost, poor bioavailability, poor safety, limited efficacy, and a lengthy design and testing process associated with cancer drug development have necessitated a ...
Pharmacy Services - Blue Cross and Blue Shield of New Mexico
Pharmacy Services - Blue Cross and Blue Shield of New Mexico

... Specialty Pharmacy Program – Specialty medications are used to treat serious or chronic conditions such as cancer, multiple sclerosis, pulmonary hypertension, hepatitis, and rheumatoid arthritis. Specialty medications are available in both injectable and oral forms; these are intended to be administ ...
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Fibromyalgia

... • Describe the risks factors and scoring/assessment of a patient with fibromyalgia. • Discuss the clinical presentation of fibromyalgia, as well as potential differential diagnoses. • Define the typical management strategies for fibromyalgia. ...
Hardy Weinberg Equiibrium with more than 2 alleles
Hardy Weinberg Equiibrium with more than 2 alleles

... Alpine skypilots and bumble bees  Next, she estimated strength of selection by bumblebees by allowing bumblebees to pollinate a caged population of plants, collected seeds and grew plants from seed.  Correlated number of surviving young with flower size of parent. Estimated the selection differen ...
Delineation of a Scab Resistance Gene Cluster on Linkage Group 2
Delineation of a Scab Resistance Gene Cluster on Linkage Group 2

... are merely linked. In any case, the fact that resistance genes are linked, has consequences for the breeding strategy when pyramiding these genes. In a typical modified backcross situation, where the resistant parent is crossed with a susceptible parent with high fruit quality, genes linked in the c ...
Meth in the Mouth
Meth in the Mouth

... Dramatic increases in methamphetamine use make it important for health care professionals to be aware of the signs and symptoms of methamphetamine use in order to most effectively educate and care for their patients. Methamphetamine is commonly referred to as “meth.” Meth has other slang terms such ...
Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas original article
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... The primary objectives of the study were to define the safety profile of brentuximab vedotin and to determine the maximum tolerated dose (the highest dose that would not produce unacceptable toxic effects). Secondary objectives were to determine pharmacokinetic measures for the antibody–drug conjuga ...
Propofol versus Remifentanil Patient Controlled Sedation for Awake
Propofol versus Remifentanil Patient Controlled Sedation for Awake

... intractable epilepsy. Each patient was randomly assigned into one of two equal groups using a computer – generated list (MS Excel 7.0 ), to receive propofol or remifentanil. Group P received propofol as a patient controlled sedation (PCS), and group R received remifentanil as PCS . Exclusion criteri ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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