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SEP 2  I  2mll
SEP 2 I 2mll

... The saliva of medicinal leeches contains many compounds (hirudin and other protein inhibitors, enzymes, etc.) that have anticoagulation, clot dissolving, and antiplatelet aggregation properties (Exhibits C-D). Therefore, the potential health risks from the use of this product in persons who are alre ...
Biological Explanations and Treatments for Depression
Biological Explanations and Treatments for Depression

... Evaluation: effectiveness and appropriateness of biological treatments Effectiveness of drug therapies: Some psychologists claim that antidepressants do not work and they simply act as a placebo, others claim that they are highly effective; the picture is not clear. Read the article The depressing n ...
Treating Chronic Pain
Treating Chronic Pain

... Provide prescriptions on a monthly basis assessing pain/effect on well-being ? Random drug screening Increase dose if unstable pain and monitor for side effects If treatment fails wean or “opioid swap”. ...
DESIGNING PERSONALIZED TREATMENT: AN
DESIGNING PERSONALIZED TREATMENT: AN

... individual patient” (p. 2386). However, there is no specific indication of how to do so, particularly for heterogenous patients with alternative medical profiles. For another example, the 2012 American College of Chest Physicians (ACCP) guidelines, Holbrook et al. (2012), “suggest that health-care p ...
Analytical data in support of the liver and peripheral blood
Analytical data in support of the liver and peripheral blood

... in five of the drugs studied, suggesting that even peripheral blood exhibited some redistribution [5]. The study reporting principally cases of overdose did not, however, convey the postmortem interval been death and autopsy. This interval (or postmortem delay) has been suggested to influence PMR [6 ...
PowerPoint lecture - Lower Cape May Regional School District
PowerPoint lecture - Lower Cape May Regional School District

... PC Users: Please wait for content to load, then click to play Mac Users: CLICK HERE ...
Full-Text PDF
Full-Text PDF

... 4 Salt selection process In the pre-formulation stages of drug development multiple salt forms can be prepared for a drug that is to be developed. Those salt forms need to be compared with regard to their physiochemical and biopharmaceutical properties. The main aim of the process is to choose an op ...
sustained release matrix type drug delivery system: a review
sustained release matrix type drug delivery system: a review

... Oral sustained release (SR) products provide an advantage over conventional dosage forms by optimizing bio-pharmaceutics, pharmacokinetics and Pharmacodynamic properties of drugs in such a way that it reduce dosing frequency to an extent that once daily dose is sufficient for penetration, polymer sw ...
You can use morphine
You can use morphine

... Beliefs about morphine ...
A Double-Blind Controlled Trial of a Single Dose Naproxen and an
A Double-Blind Controlled Trial of a Single Dose Naproxen and an

... of people during their lifetime. Nonsteroidal antiinflammatory drugs are the most commonly used drugs in the treatment of pain and inflammation.51–59 However, their use is limited by adverse drug side effects notably GI toxicity.6,60,61–64 The adverse effects of NSAIDS are dose related.65–72 The cur ...
Exploring ClinVar
Exploring ClinVar

... Exploring ClinVar: What's There and How Do I Use It? Melissa Landrum ICCG June 12, 2014 ...
Lesson Overview
Lesson Overview

... All members of the population must have an equal opportunity to produce offspring. Individuals must mate with other members of the population at random. In natural populations, however, mating is not random. Female peacocks, for example, choose mates on the basis of physical characteristics such as ...
CH # 17-2
CH # 17-2

... All members of the population must have an equal opportunity to produce offspring. Individuals must mate with other members of the population at random. In natural populations, however, mating is not random. Female peacocks, for example, choose mates on the basis of physical characteristics such as ...
Heredity Review Sheet - Old Saybrook Public Schools
Heredity Review Sheet - Old Saybrook Public Schools

... Does not mean an individual can have more than two alleles! l  Only means that more than two versions of the gene (allele) exist in the population l  l  ...
8: Malignant disease and immunosuppression
8: Malignant disease and immunosuppression

... This handbook lists all the approved chemotherapy protocols, which contain details of prescribing issues, management of toxic effects and supportive care. When oral cytotoxic drugs are used for the treatment of malignant disease, the whole course will be dispensed by the hospital pharmacy. The presc ...
ADHD MEDICATIONS EBOOK
ADHD MEDICATIONS EBOOK

... When is methylphenidate prescribed? Methylphenidate is used to treat children and adults 6 – 65 with a chronic history of short attention span, distractibility, impulsivity, moderate-to-severe hyperactivity, and abnormal EEG. The drug is also used to treat narcolepsy. Methylphenidate should not be g ...
LORTAB ® 7.5 mg/500 mg
LORTAB ® 7.5 mg/500 mg

... A single or multiple drug overdose with hydrocodone and acetaminophen is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended. Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption. Oxygen, i ...
Prozac, Prozac Weekly, and Sarafem (fluoxetine)
Prozac, Prozac Weekly, and Sarafem (fluoxetine)

... Most cases of major depression can be treated successfully, usually with medication, psychotherapy, or both. The combination of psychotherapy and antidepressants is very effective in treating moderate to severe depression. The medications improve mood, sleep, energy, and appetite while therapy stren ...
Dalteparin shared care guidelines
Dalteparin shared care guidelines

...  To prescribe and adjust the dose as recommended by the specialist.  To ensure there are no interactions with any other medications initiated in primary care.  To continue monitoring as agreed with secondary care (guideline should include details of monitoring requirements and what to do when eac ...
2: Cardiovascular system - Gateshead Health NHS Foundation Trust
2: Cardiovascular system - Gateshead Health NHS Foundation Trust

... - Disopyramide capsules 100mg: orally 300-800mg daily in divided doses - Lidocaine injection 10mg/mL (1%), 20mg/mL (2%); infusion 1mg/mL (0.1%) and 2mg/mL (0.2%) in glucose 5%, 500mL. - Flecainide tablets 50mg, 100mg; injection 10mg/mL: orally, ventricular arrhythmias, 100mg twice daily; max 400mg d ...
Module 2. Clinical Pharmacy in gastroenterology, hepatology
Module 2. Clinical Pharmacy in gastroenterology, hepatology

... an hour after exposure to an antigen to which the individual has been sensitized B. * An allergic reaction that becomes apparent only hours after contact C. An allergic reaction that results from the formation of antigen-antibody complexes between a foreign antigen and IgM or IgG. (It occurs during ...
LORTAB® 7.5/500
LORTAB® 7.5/500

... Clinical studies of hydrocodone bitartrate and acetaminophen tablets did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly ...
BioInvent Interim Report 1 January – 30 June 2015
BioInvent Interim Report 1 January – 30 June 2015

... In Europe and North America, around 157,000 people every year are diagnosed with NHL and around 35,000 with CLL. BioInvent’s drug candidate BI-1206 is a fully human antibody aimed at CD32b, an immunosuppressive protein that is overexpressed in patients with lymphoma, especially in patients who respo ...
Full Prescribing Information including BOXED WARNING
Full Prescribing Information including BOXED WARNING

... neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts. If opioid use is required for a prolonged period in a pregnant woman, advise the patient of the risk of neonatal opioid w ...
NEW ZEALAND DATA SHEET CLOZARIL® (clozapine) 25mgand
NEW ZEALAND DATA SHEET CLOZARIL® (clozapine) 25mgand

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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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