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x/xy chromosome mosaicism: turner syndrome and
x/xy chromosome mosaicism: turner syndrome and

... The Y chromosome in X/XY chromosome mosaics is frequently damaged, and these aberrations lead to postzygotic nondisjunction causing chromosome mosaicism. Microdeletions of the Y chromosome may be associated with Y chromosome instability leading to formation of ambiguous genitalies. When the short ar ...
NAME OF THE MEDICINE: Desmopressin Acetate Synonyms
NAME OF THE MEDICINE: Desmopressin Acetate Synonyms

... By Intranasal and Parenteral Administration . The treatment of ADH-sensitive cranial diabetes insipidus, including treatment of post-hypophysectomy polydipsia and polyuria. DDAVP is ineffective for the treatment of nephrogenic diabetes insipidus. Parenteral administration may be used when the intran ...
Product Monograph - Sanofi Genzyme Canada
Product Monograph - Sanofi Genzyme Canada

... During the randomized clinical trial, five patients experienced fatal infectious adverse events (sepsis or septic shock). All had grade 4 neutropenia and one had febrile neutropenia. One additional patient death was attributed to neutropenia without a documented infection (see ADVERSE REACTIONS, Cli ...
STEP 2: Identify presence of clinical atherosclerotic
STEP 2: Identify presence of clinical atherosclerotic

... blood pressure ...
Hypertension Management of the “Difficult Patient”
Hypertension Management of the “Difficult Patient”

... stenosis. Careful selection based on clinical evaluation, which can increase the pretest probability to 20% to 40%, is a prerequisite for cost-effective use of these tests in the work-up strategy for patients with possible renovascular hypertension Because only a limited number of published studies ...
Naturopathy Act, 2007 - O. Reg. 168/15
Naturopathy Act, 2007 - O. Reg. 168/15

... member prescribed a drug for the patient and provide details respecting the prescription, unless the patient refuses to consent to the notification. 7. Where a limitation, a route of administration or a dosage is indicated in the column opposite the drug in Table 3, a member shall only prescribe tha ...
CILOXAN - ciprofloxacin hydrochloride solution Alcon
CILOXAN - ciprofloxacin hydrochloride solution Alcon

... 1 to 8 days (seven within the first 24-72 hours), in five patients, resolution was noted in 10-13 days. In nine patients, exact resolution days were unavailable; however, at follow-up examinations, 18-44 days after onset of the event, complete resolution of the precipitate was noted. In three patien ...
Twynsta
Twynsta

... The frequency of adverse reactions was not related to gender, age, or race. The adverse reactions that occurred in the placebo-controlled factorial design trial in ≥2% of patients treated with TWYNSTA and at a higher incidence in TWYNSTA-treated patients (n=789) than placebotreated patients (n=46) w ...
ORIGINAL RESEARCH—PEYRONIE`S DISEASE Topical Verapamil
ORIGINAL RESEARCH—PEYRONIE`S DISEASE Topical Verapamil

... Methods. Two simultaneous, three armed, double blinded, placebo-controlled studies were conducted. After randomization into one of four groups, patients were treated for 3 months. At the end of 3 months’ treatment using blinded drug, each patient was treated with open label topical verapamil for 6 m ...
7: Obstetrics, Gynaecology and Urinary Tract Disorders
7: Obstetrics, Gynaecology and Urinary Tract Disorders

... - Depo-Provera® injection (medroxyprogesterone acetate 150mg/mL aqueous suspension): by deep intramuscular injection, 150mg within first 5 days of cycle or within first 5 days after parturition (delay until 6 weeks after parturition if breast-feeding); for long-term contraception, repeated every 12 ...
NATURAL AND PARTIALLY SYNTETIc ANALGESIcS
NATURAL AND PARTIALLY SYNTETIc ANALGESIcS

... the way of emotional reaction towards pain. It also has sedative effects (3). Morphine has strong analgesic characteristics (50 times stronger than aspirine) and it is used only in cases of very strong pain. In higher doses, it has narcotic properties (12). Morphine is used to relieve the most sever ...
Diuretics and Synthetic Hypoglycemic Drugs
Diuretics and Synthetic Hypoglycemic Drugs

... Sulfonylureas(磺酰脲类)  The hypoglycemic(降血糖)effect of salicylates(水杨酸 盐)has been known for 100 years. Clinical use of salicylates was not feasible, since the very large doses required produced intolerable side effects.  The hypoglycemic effects of the thiadiazole sulfonamide known as IPTD, used to ...
Current Status and Future Prospects for Public
Current Status and Future Prospects for Public

... CML333 ...
Heredity and Genetics - Olympic High School Home Page
Heredity and Genetics - Olympic High School Home Page

... 1. What is the trait for the flowers? __________________ Type of Hair 2. What is the trait for the animals? __________________ f (or narrow) 3. What is the recessive allele for the flower trait? _______ H (or straight) 4. What is the dominant allele for the animal trait? _______ ...
Genetic Testing for Predisposition to Inherited Hypertrophic
Genetic Testing for Predisposition to Inherited Hypertrophic

... family, analyzes the genes that are most commonly associated with genetic variants for HCM and evaluates whether any potentially pathogenic mutations are present. Some available panels include testing for multisystem storage diseases that may include cardiac hypertrophy, such as Fabry disease (GLA), ...
Assessment of blinding in clinical trials
Assessment of blinding in clinical trials

... interventions, or of psychological vs. no treatments. In drug trials, comparing active treatment with placebo or competing active treatment, however, researchers have established many methods to assure the achievement of blinding, such as making the appearance, smell and taste of active drug and pla ...
Pharmacology Review - Southwest General Hospital
Pharmacology Review - Southwest General Hospital

... • ET drugs deliver low blood levels. All drugs except Epi are given 2-3x’s normal dose. • Epi in low levels may produce transient, detrimental vasodilatation thus… Epi down the ET Tube is given 10 x’s the normal dose. • Instill the drug while briefly holding compressions, follow with 5mL (smaller wi ...
Counseling in couples with genetic abnormalities
Counseling in couples with genetic abnormalities

... may need to be obtained before further details can be accessed. Referral to a genetic center is recommended, as these centers are used to collecting relevant information. It is then necessary to ascertain whether a couple is at risk of having an affected baby and what they would wish to do if the ba ...
Spiriva Respimat [product monograph].
Spiriva Respimat [product monograph].

... may be a life-threatening condition. If SPIRIVA RESPIMAT no longer controls the symptoms of bronchoconstriction, or the patient’s inhaled, short-acting beta 2 -agonist becomes less effective or the patient needs more inhalation of a short-acting bronchodilator than usual, these may be markers of det ...
Product Information: Ibuprofen
Product Information: Ibuprofen

... upper GI ulcers, gross bleeding or perforation, caused by NSAIDs, appear to occur in approximately 1% of patients treated for 3-6 months, and in about 2-4% of patients treated for one year. These trends continue thus, increasing the likelihood of developing a serious GI event at some time during the ...
Alleviating effect of active hexose correlated compound (AHCC) for
Alleviating effect of active hexose correlated compound (AHCC) for

... that AHCC is an inducer of CYP450 2D6. AHCC does have the potential for drug-drug interactions involving CYP450 2D6 such as ondansetron, however overall data suggests that AHCC would be safe to administer with most other chemotherapy agents that are not metabo­ lized via the CYP450 2D6 pathway (21). ...
Popular-Sire Syndrome - National Breed Clubs
Popular-Sire Syndrome - National Breed Clubs

... dogs develop the disease. Testing Boxers for the DM susceptibility gene shows 39% testing carrier, and 43% testing homozygous “at risk” for the susceptibility gene. This is an example of a genetic test with low penetrance; indicating that the homozygous state is poorly predictive of clinical disease ...
Back to Basics: Substance Use/Abuse/Withdrawal
Back to Basics: Substance Use/Abuse/Withdrawal

... Case 2 • Lisa started smoking marijuana and drinking alcohol when she was 13. She started using cocaine when she was 15. She currently smokes 2 grams of marijuana a day. Smokes crack cocaine 2-3 times per week usually a 40 piece. She drinks 6 tall beers (710ml) per day. Four years ago she was presc ...
Treatment Options for Parkinson`s Disease
Treatment Options for Parkinson`s Disease

... Dizziness This is often caused by low blood pressure (hypotension). Dizziness most often occurs in the early stages of treatment and during periods of hot weather, but it often responds to simple measures and may wear off over time. However, if your balance is poor and you feel dizzy, you may fall a ...
RESTLESS LEG SYNDROME
RESTLESS LEG SYNDROME

... the first 2 weeks until symptom relief, then up to a maximum of 2 mg/day (mean dose was 1.45 mg/day). Levodopa SR dose was 100/25 mg PO daily, then doubling after 2 weeks until symptom relief (mean levodopa dose 190 mg/day). Vomiting reported in one levodopa patient resulted in study discontinuation ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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