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Pegicol™ – Oral treatment for chronic constipation and faecal
Pegicol™ – Oral treatment for chronic constipation and faecal

... years of age. It is also used to prevent the recurrence of faecal impaction in children. # Faecal impaction is defined as refractory constipation with faecal loading of the rectum and/or colon confirmed by physiological or radiological examination of the bowel or rectum. Mode of action Pegicol™ is a ...
Heterogeneity of Concentrated Prescribing Behavior
Heterogeneity of Concentrated Prescribing Behavior

... Consider a physician seeing a patient with a confirmed diagnosis for which several alternative pharmaceutical treatments are available. Suppose that, given the clinical evidence, patient response to a given treatment is idiosyncratic and unpredictable in terms of both efficacy and side effects. What ...
mendelian genetics review questions
mendelian genetics review questions

rajiv gandhi university of health sciences
rajiv gandhi university of health sciences

... of dementia, heart failure, and mortality from cardiovascular disease7. There are many classes of antihypertensive, which lower blood pressure by different means; among the most important and most widely used are the thiazide diuretics, the ACE inhibitors, the calcium channel blockers, the beta bloc ...
Document
Document

... Response: was corrected to: development Whereas, there were no hairy roots formed from control explants. When cotyledon explants were also infected and co-cultured with Agrobacterium, no hairy roots induced on these explants. Response: the statement was changed to: , whereas no adventitious roots fo ...
Subsys Prescribing Information
Subsys Prescribing Information

... Monitor closely, particularly during initiation and titration. (5.9)  Serotonin Syndrome: Potentially life-threatening condition could result from concomitant serotonergic drug administration. Discontinue SUBSYS if serotonin syndrome is suspected. (5.10)  Adrenal Insufficiency: If diagnosed, treat ...
ANISOCHILUS CARNOSUS TETRA CHLORIDE –INDUCED HEPATOTOXICITY IN ALBINO RATS Full Proceeding Paper
ANISOCHILUS CARNOSUS TETRA CHLORIDE –INDUCED HEPATOTOXICITY IN ALBINO RATS Full Proceeding Paper

... hepatocytes. The levels of these enzymes maintain a low circulating level. When a cell is damaged, the enzyme leaks into the blood, dramatically increasing their levels in the serum [15]. The cells lining the biliary ducts of the liver synthesise the enzyme Alkaline phosphatase (ALP). Bile duct obst ...
Delivery of Quercetin as an Antioxidant Agent to Cancer Cells... Carbon Nanotubes  Jafar Ezzati Nazhad Dolatabadi
Delivery of Quercetin as an Antioxidant Agent to Cancer Cells... Carbon Nanotubes Jafar Ezzati Nazhad Dolatabadi

... received more attention as dietary constituents during the last few years. Experimental studies verified that they possess many beneficial effects on human health, including cardiovascular protection, anticancer activity, antiulcer effects, antiallergic, antiviral, and anti-inflammatory properties [ ...
click here to the doc
click here to the doc

... Many beta-blockers are now available and in general they are all equally effective. There are, however, differences between them which may affect choice in treating particular diseases or individual patients. Beta-blockers with a relatively short duration of action have to be given two or three time ...
Suggestion from clinicians
Suggestion from clinicians

... effective for some people with painful neuropathic pain conditions. No evidence regarding a doseresponse effect was available for doses above 1200 mg daily, but limited evidence suggested that doses lower than 1200 mg daily were less effective. The outcome of at least 50% pain intensity reduction is ...
here
here

... Gong X, Shuang M, Liu J, Yang X, Zhang D. Institute of Mental Health, Peking University, Beijing, China. Significant genetic association found between autism and two of the SNPs of the NRP2 gene (rs849578: P = 0.017, rs849563: P = 0.027), as well as specific haplotypes, especially those formed by rs ...
In Vitro and In Vivo Evaluation of Microparticulate Drug
In Vitro and In Vivo Evaluation of Microparticulate Drug

... Although a similar method was applied to CM-Ch-MMC, its nanoparticles could not be produced, and the mean size was more than 10 μm. The droplet size of the aqueous phase in the W/O mixture was considered to influence the size of the particles. Smaller droplets are suitable for the preparation of sma ...
Use of Methadone for the Treatment of Diabetic
Use of Methadone for the Treatment of Diabetic

... MICHELLE DORAN, APRN, BC-PCM KARYN GEARY, APRN, BC-PCM ...
“The Genetics of Depression and Related Traits,” by Patricia Huezo
“The Genetics of Depression and Related Traits,” by Patricia Huezo

... heightened responsiveness to stress, which in the genetically vulnerable individual may then evolve into psychiatric disorders such as depression [22]. In summary, the above evidence shows the importance of obtaining environmental records for each subject tested, and considering their effects on any ...
Genetics Study Guide
Genetics Study Guide

... 79. “Blood type” is a classification of blood based on the presence or absence of certain proteins. There are 4 different blood types: A, B, AB, and O. Identify blood type as a multiple-allele trait or a polygenic trait, and defend you answer. ...
November 2014 - Academy of Managed Care Pharmacy
November 2014 - Academy of Managed Care Pharmacy

... (vD.0) supports over 20 transaction functions and facilitates the exchange of over 4 billion real-time pharmacy claims with such speed and simplicity that most participants do not realize they are using sophisticated HIT.2 Unlike medical claims that are still predominantly submitted in “batches” ove ...
Therapeutics Review
Therapeutics Review

... xenatide (Byetta) is the first glucagon-like peptide-1 analogue (GLP-1 analogue) to be approved for the treatment of type 2 diabetes. It is a twice-daily injection, currently prescribable only by consultants, given before breakfast and before the evening meal. The early signs are that this new and d ...
A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension
A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension

... and clopidogrel modestly decreased plasma P-selectin levels, although this did not reach statistical significance, and there was a possible sequence effect (p, 0.01). There were no significant differences in ASA or clopidogrel effects between patients receiving epoprostenol and those who were not (f ...
Fuzeon® Prescribing Information
Fuzeon® Prescribing Information

... 123 patients had a confirmed or probable pneumonia event in this study (62 in the FUZEON treatment arm with 1962 patient-years of observation and 61 in the non-FUZEON treatment arm with 3378 patient-years of observation). The incidence of pneumonia was 3.2 events/100 patient-years in the FUZEON trea ...
full text pdf
full text pdf

... (OP) have a benign self-limited disease in which pathologic changes are restricted to the oral mucosa. On the other hand, patients with ocular cicatricial pemphigoid, a chronic condition marked by relapses and remissions, have ocular involvement and also perhaps involvement of other mucous membranes ...
Foundation - The Learning Oasis
Foundation - The Learning Oasis

... European cities. Scientists began to share their research by publishing their work in journals. During this time, William Harvey discovered how blood circulated through the body and Edward Jenner invented a vaccination for smallpox after discovering the relationship between cowpox and smallpox. Each ...
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Here`s - MathBench
Here`s - MathBench

... chromosome stayed on the same chromosome. If that was true, then each parent could only have 2 rather than 4 variations on their gametes, and the punnett squares would be easy to figure out. However, just because two alleles start out on the same chromosome does not mean they stay there! Chromosomes ...
Discovery Of Genetic Mutations That Cause Stuttering
Discovery Of Genetic Mutations That Cause Stuttering

... Mutation associated with stuttering in family PKST72 • The same mutation occurs in affected individuals in ...
Genetic Algorithms: A Tutorial
Genetic Algorithms: A Tutorial

... “Almost eight years ago ... people at Microsoft wrote a program [that] uses some genetic things for finding short code sequences. Windows 2.0 and 3.2, NT, and almost all Microsoft applications products have shipped with pieces of code created by that system.” - Nathan Myhrvold, Microsoft Advanced Te ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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