• Study Resource
  • Explore
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
Drugs - Hormone Restoration
Drugs - Hormone Restoration

... Adinoff B, Junghanns K, Kiefer F, Krishnan-Sarin S. Suppression of the HPA axis stress-response: implications for relapse. Alcohol Clin Exp Res. 2005 Jul;29(7):1351-5. This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alc ...
peptic ulcer
peptic ulcer

... The Ideal Drug to Achieve Potent Acid inhibition • Ideal drug should be able to maintain pH > 4 for ≥ 16 hr/day • Such level guarantee a consistent response to treatment, & sufficient for most refractory cases of peptic acid disease • Efficacy of the drug would also have to be consistent, so that s ...
Genetics of ankylosing spondylitis
Genetics of ankylosing spondylitis

... Certainly B27 subtype differences play no role in western European populations in determining those B27-positive individuals who will develop AS (41). Non-B27 MHC genes There is strong evidence that B27 is not the only MHC gene involved in susceptibility to AS. As indicated above, linkage studies wi ...
Toxicology and safety pharmacology and metabolic studies
Toxicology and safety pharmacology and metabolic studies

... FDA may expect much >10 fold margin, if severe toxicity, steep dose response, irreversible or non-monitorable toxicities etc. http://www.fda.gov/cber/gdlns/dose.pdf ...
These highlights do not include all the information needed
These highlights do not include all the information needed

... 8.3 Nurs ing Mothers It is not known whether topically applied acyclovir or hydrocortisone is excreted in breast milk. Systemic exposure following topical administration of either drug is expected to be below detection limits. Because many drugs are excreted in human milk, caution should be exercise ...
Medications Used in the Treatment of Addiction
Medications Used in the Treatment of Addiction

... produced by the combination of cocaine and disulfiram appears to override such rewarding effects by increasing the incidence of such cocaine-associated effects as paranoia and anxiety. These medications are currently being tested as possible pharmacologic adjuncts to cocaine dependence treatment: ...
General Outline for Antibiotics (a good study guide)
General Outline for Antibiotics (a good study guide)

... 2. agents act as haptens when bound to serum proteins 3. rashes will disappear when drug is withdrawn, can use antihistamines or glucocorticoids 4. for patients with allergies, use a different drug or try to desensitize B. other adverse reactions 1. pain and sterile inflammatory reactions at sites o ...
INT EG RITY   AMB UL AN CE ... S T AN D IN G  O R D...
INT EG RITY AMB UL AN CE ... S T AN D IN G O R D...

... applied to any patient under the care of an Integrity Ambulance Service EMS provider. EMS providers are reminded that when utilizing these protocols that they are to remain within the confines of the State of Ohio EMS Scope of Practice for their particular EMS certification level. Integrity Ambulanc ...
Dietary Supplements: How Safe and Effective are They?
Dietary Supplements: How Safe and Effective are They?

... Cherokee tribe to stimulate breast milk after childbirth and for other menstruation ...
Protecting Public Health from Outside the Physician`s Office: A
Protecting Public Health from Outside the Physician`s Office: A

... position is that any private industry promotion, e.g., labeling or marketing, of unapproved drug uses may result in both physicians and patients being unable to make informed and unbiased decisions.11 Off-label drug use is pervasive in the United States and both its risks and benefits are widely rec ...
Hydroxyzine-Induced Dystonia
Hydroxyzine-Induced Dystonia

... gastro-intestinal tract with a peak blood-level of about two hours after oral administration [3]. Common adverse-effects of hydroxyzine in children include adverse central nervous system effects, causing sedation, decreased cognitive function and increased subjective somnolence [4]. However a few ca ...
PRODUCT MONOGRAPH Codeine Contin
PRODUCT MONOGRAPH Codeine Contin

... Withdrawal (Abstinence) Syndrome). Therefore, patients on prolonged therapy should be withdrawn gradually from the drug if it is no longer required for pain control. Use in Drug and Alcohol Addiction Codeine Contin is an opioid with no approved use in the management of addictive disorders. Its prope ...
Paracetamol-induced hypotension on the intensive care unit
Paracetamol-induced hypotension on the intensive care unit

... Paracetamol has acquired a well-established role for pain relief and fever management throughout the whole world. It is a well-accepted drug in the clinical setting given its predictable side effect range. In the following case report, we present hypotension as an unfamiliar side effect, found in a ...
Enthusiasm mixed with scepticism about single
Enthusiasm mixed with scepticism about single

... ethical guidelines are worked out also for the common complex disorders, so that the results of the intense research on human genetic variation using SNPs can be fully used for the benefit of more targeted and preventive health care in the future. ...
Femara - Novartis
Femara - Novartis

... Subjects with cirrhosis and severe hepatic impairment who were dosed with 2.5 mg of Femara experienced approximately twice the exposure to Femara as healthy volunteers with normal liver function. Therefore, a dose reduction is recommended for this patient population. The effect of hepatic impairment ...
No Slide Title
No Slide Title

... •diarrhea, nausea, abnormal liver tests •acute attacks of gout •rash ...
Drug-Induced Acute Renal Dysfunction Acute Renal Failure: PRE
Drug-Induced Acute Renal Dysfunction Acute Renal Failure: PRE

Chapter 5: Mendelian Traits and Behavior
Chapter 5: Mendelian Traits and Behavior

... A phenotype is defined as the observed characteristic or trait. Height, weight, extraversion, intelligence, interest in blood sports, memory, and shoe size are all phenotypes. There is not always a simple, one-to-one correspondence between a genotype and a phenotype. For example, there are four phen ...
3.2 Punnett Squares
3.2 Punnett Squares

... A homozygous dominant brown eyed male mates with a heterozygous female. ...
analgesic
analgesic

... and serum urea/creatinine. Five original papers were reviewed in detail for this article. Including our own experience, a total of 52 (including five bilateral) cases of LPHS treated with capsaicin are reviewed. RESULTS: Our patients received a total of four capsaicin instillations producing an aver ...
6_Pain and Inflammation_Afferent andf Efferent Nervous System
6_Pain and Inflammation_Afferent andf Efferent Nervous System

... • Maximizing therapeutic effects • Confirm diagnosis of type of headache the patient is having. • Administer drug as soon as headache begins. • Minimizing adverse effects • Assess the patient for a history of cardiovascular or cerebrovascular disorder. • After administering sumatriptan, monitor for ...
ceftin tablets and oral suspension
ceftin tablets and oral suspension

... CEFTIN for oral suspension is indicated for the treatment of pediatric patients aged 3 months to 12 years with mild-to-moderate acute bacterial maxillary sinusitis caused by susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae (non-β-lactamase–producing strains only). Limitation ...
A.3.1.5SecretsInGenes - Life Science Academy
A.3.1.5SecretsInGenes - Life Science Academy

... expression of a smoker’s lung cells and lung cells from a non-smoker. Researchers could use this information to learn more about the progression of lung cancer and potentially design treatment strategies. But are all cases of cancer the same? Is the gene expression the same in Mike Smith’s osteosarc ...
The landscape of microbial phenotypic traits and associated genes
The landscape of microbial phenotypic traits and associated genes

... not be represented in existing databases. To this end, we constructed a standard ‘bag-of-words’ representation: a matrix where rows correspond to words and columns to organisms for each of the five corpora separately (excluding the mixed collection). In order to enforce consistency between corpora, ...
A drug or device shall be deemed to be misbranded—
A drug or device shall be deemed to be misbranded—

... the event of inconsistency between the requirements of this paragraph and those of paragraph (e) as to the name by which the drug or its ingredients shall be designated, the requirements of paragraph (e) shall prevail. (h) Deteriorative drugs; packing and labeling If it has been found by the Secreta ...
< 1 ... 343 344 345 346 347 348 349 350 351 ... 1254 >

Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report