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Treatment Options for Wet Macular Degeneration (MD)
Treatment Options for Wet Macular Degeneration (MD)

... treatment does not cause direct damage to the surrounding retina. It therefore can be used to treat new vessels that are under the centre of vision. There are two types of new vessels (CNV) seen in wet MD. One is clearly delineated by fluorescein angiography and is called classic; the other is diff ...
Health Services Insights public Health Implications of Household
Health Services Insights public Health Implications of Household

... of 73.3 years (standard deviation [SD], 14.1). At the time of death, the mean number of drugs per patient was 9.7 (SD, 4.2).21 The top 10 drugs wasted following the death of these patients are listed in Table 2. With the exception of haloperidol, all of the top 10 drugs wasted were controlled substa ...
local drug delivery systems in the treatment of
local drug delivery systems in the treatment of

... Periodontitis, a disease involving supportive structures of the teeth prevails in all groups, ethnicities, races and both genders. It is a localised inflammatory response caused by bacterial infection of a periodontal pocket associated with subgingival plaque. Periodontal diseases include conditions ...
GUIDELINES FOR THE MANAGEMENT OF TUBERCULOSIS IN CHILDREN
GUIDELINES FOR THE MANAGEMENT OF TUBERCULOSIS IN CHILDREN

... given. Where the index patient has Rifampicin mono resistant TB, the child contact may be given Isoniazid 10mg/kg daily for 6 months Recommended regimen for TB prophylaxis: Isoniazid (INH) 10 (10-15) mg/kg/day for 6 months. Caregivers should be advised to crush the appropriate fraction of the 100mg ...
Guidelines for the management of tuberculosis in children, 2013
Guidelines for the management of tuberculosis in children, 2013

Supplementary material for “Modularity in the genetic
Supplementary material for “Modularity in the genetic

... unchanged. The Q values of the randomized networks are all slightly greater than 0.2, but the value of an actual network is 0.78. The z-score ( z  (Q  Q) /  , where Q and  are the mean and standard deviation of modularity Q ), which measures the improbability that the observed result is due to c ...
Synthetic cannabinoid case study – various brands | Male
Synthetic cannabinoid case study – various brands | Male

... The term legal high might imply that these substances are safe but this is an incorrect assumption. This misconception extends to drugs in general and many people believe that alcohol and nicotine are less harmful than illegal drugs, which isn’t true in many cases. Although the term legal high is mi ...
Opioids In Chronic Noncancer Pain: Have We Reached A Boiling
Opioids In Chronic Noncancer Pain: Have We Reached A Boiling

... Opioid sales in the USA increased 7-fold from 1997 to 2010 from morphine equivalence of 96 mg per person to 710 mg per person (Fig. 1). Described simply, enough opioids are sold so that 15 mg of hydrocodone can be administered everyday to every American adult for 47 consecutive days. In addition, in ...
Maximum Dosage Policy
Maximum Dosage Policy

Eltroxin - Medsafe
Eltroxin - Medsafe

... Australia and the United Kingdom, countries in which the GSK brand is not available, have informed Medsafe that they have reports of adverse reactions of a similar nature to all three classes of adverse reactions described above, submitted when patients changed brands of levothyroxine. These reports ...
A Mathematical Model for an Intravenous Bolus Injection
A Mathematical Model for an Intravenous Bolus Injection

Full-text  - Tropical Journal of Pharmaceutical Research
Full-text - Tropical Journal of Pharmaceutical Research

... prodrug and is rapidly and completely converted to phenytoin by phosphatases present in the liver, red blood cells and many other tissues [7]. Severe malaria is a major cause of admissions in the tropics [9,10], and is associated with a casefatality rate of 10 – 30 % among hospital admissions [11-13 ...
Anti-Vascular Endothelial Growth Factor Drugs for the
Anti-Vascular Endothelial Growth Factor Drugs for the

Drug-like properties and the causes of poor solubility
Drug-like properties and the causes of poor solubility

formulation and delivery strategies
formulation and delivery strategies

... of polymer degradation has an important role in the mechanism and rate of release of the drug from microspheres. In addition, diffusion of the protein through the biological fluid surrounding the microsphere is dependent on the size of the protein, and this will affect the rate of absorption after r ...
Long-acting beta2- adrenoreceptor agonists: salmeterol and
Long-acting beta2- adrenoreceptor agonists: salmeterol and

... pharmacological properties: both are highly selective and potent beta2-adrenoreceptor agonists, with relaxant effects on bronchial smooth muscle in vitro. However, some significant pharmacological differences between these drugs have been documented in vitro and in patients, as shown in Table 1.2 Fo ...
Drugs Hanson 13
Drugs Hanson 13

... derived from friends who use marijuana (“funtimes when high with friends”). ...
Gregory W. Albers, Sven Jacobson, J. Marc Simard and Barney J
Gregory W. Albers, Sven Jacobson, J. Marc Simard and Barney J

... Radiology (A.J.Y.), Massachusetts General Hospital, Boston; Department of Public Health Services, Medical University of South Carolina, Charleston (J.J.E.); Department of Neurology, Michael E. DeBakey VA Medical, Baylor College of Medicine, Houston, TX (T.A.K., P.M.); Department of Neurology, Klinik ...
NOVEL NANOEMULSION AS VEHICLES FOR TRANSDERMAL DELIVERY OF CLOZAPINE: IN VITRO
NOVEL NANOEMULSION AS VEHICLES FOR TRANSDERMAL DELIVERY OF CLOZAPINE: IN VITRO

... over the skin for a long period [11]. Oil/water (o/w) nanoemulsions are promising colloidal drug carrier systems for diverse therapeutic applications. Successfully developed, intravenous, oral and ocular delivery systems showed reduced side effects of various potent drugs and prolonged pharmacologic ...
Pharmacologic therapy of cancer pain
Pharmacologic therapy of cancer pain

... By titrating doses over four days, equivalent pain ratings were achieved with both drugs. More patients and nurses preferred morphine, although constipation and nausea were less severe and total side effects were fewer with tramadol. ...
Macrolids
Macrolids

... The major metabolite is 14-hydroxyclarithromycin, which also has antibacterial activity. A portion of active drug and this major metabolite is eliminated in the urine, and dosage reduction (eg, a 500-mg loading dose, then 250 mg once or twice daily) is recommended for patients with creatinine cleara ...
Supplementary Table S1
Supplementary Table S1

... NCCN consensus that the intervention is appropriate.”) CAP: “ALK molecular testing should be used to select patients for ALK-targeted TKI therapy, and patients with lung adenocarcinoma should not be excluded from testing on the basis of clinical characteristics.” (Evidence Grade: ALK: B - “Body of e ...
Duloxetine and Other Antidepressants in the
Duloxetine and Other Antidepressants in the

... patients compared with those on placebo also experienced significant improvement in tender point number and mean tender point pain threshold. For the tender point assessment, a Fisher dolorimeter with a rubber disk of 1 cm2 [22] was applied to the 18 tender point sites defined by the ACR criteria [1], ...
TARCEVA Product Monograph
TARCEVA Product Monograph

... Bullous and exfoliative skin disorders: Bullous, blistering and exfoliative skin conditions have been reported, including very rare cases suggestive of Stevens-Johnson syndrome/Toxic epidermal necrolysis, which in some cases were fatal (see ADVERSE REACTIONS, Clinical Trial Adverse Drug Reactions). ...
Connective Tissue Disorders 61 Gene Panel
Connective Tissue Disorders 61 Gene Panel

... Professor of Paediatric Bone Disease Heads of Metabolic Bone Disease Sheffield Children's NHS Foundation Trust 14. Based on experience what will be the national (UK wide) activity, per annum, for: Index cases: 965 Family members where mutation is known: 345 15. If your laboratory does not have capac ...
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Pharmacogenomics

Pharmacogenomics (a portmanteau of pharmacology and genomics) is the study of the role of genetics in drug response. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with drug absorption, distribution, metabolism and elimination, as well as drug receptor target effects. The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics focuses on single drug-gene interactions, while pharmacogenomics encompasses a more genome-wide association approach, incorporating genomics and epigenetics while dealing with the effects of multiple genes on drug response.Pharmacogenomics aims to develop rational means to optimize drug therapy, with respect to the patients' genotype, to ensure maximum efficacy with minimal adverse effects. Through the utilization of pharmacogenomics, it is hoped that drug treatments can deviate from what is dubbed as the “one-dose-fits-all” approach. It attempts to eliminate the trial-and-error method of prescribing, allowing physicians to take into consideration their patient’s genes, the functionality of these genes, and how this may affect the efficacy of the patient’s current and/or future treatments (and where applicable, provide an explanation for the failure of past treatments). Such approaches promise the advent of ""personalized medicine""; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Whether used to explain a patient’s response or lack thereof to a treatment, or act as a predictive tool, it hopes to achieve better treatment outcomes, greater efficacy, minimization of the occurrence of drug toxicities and adverse drug reactions (ADRs). For patients who have lack of therapeutic response to a treatment, alternative therapies can be prescribed that would best suit their requirements. In order to provide pharmacogenomic-based recommendations for a given drug, two possible types of input can be used: genotyping or exome or whole genome sequencing. Sequencing provides many more data points, including detection of mutations that prematurely terminate the synthesized protein (early stop codon).
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